Articles tagged "Kidney transplantation"

2019 American Transplant Congress
Impact of Belatacept Conversion on Renal Function, Histology and Gene Expression in Kidney Transplant Patients with Chronic Active Antibody-Mediated Rejection
D. Kumar¹, M. Raynaud², P. Halloran³, A. Loupy², J. Chang³, J. Reeve³, I. Yakubu¹, S. Bobba¹, L. Kamal¹, M. Levy¹, C. Bhati¹, P. Kimball¹, A. King¹, G. Gupta¹
¹Virginia Commonwealth University, Richmond, VA, ²Paris Transplant Group, Paris, France, ³Alberta Transplant Genomics Applied Centre, Edmonton, AB, Canada
*Purpose: Chronic active antibody mediated rejection (cABMR) is a major cause of long-term kidney transplant (KT) loss. Current therapies have unclear efficacy and significant side…
2019 American Transplant Congress
High Numbers of Differentiated CD8⁺CD28^– T Cells Are Associated with a Substantially Lowered Risk for Late Rejection and Graft Loss after Kidney Transplantation
M. G. Betjes, A. Langerak, M. Klepper, N. Litjens
Nephrology & Transplantation, Erasmus MC, Rotterdam, Netherlands
*Purpose: Recipients of a kidney transplant have a prematurely aged T-cell system. This is reflected in lowered thymic output, reduced telomere length and more highly…
2019 American Transplant Congress
Multi-Organ Transplant Results in Lower Patient and Graft Survival Than Kidney Alone Transplant
C. A. Custer¹, J. Entwistle², K. Ladin³, L. Cartwright¹, E. J. Gordon⁴
¹United Network for Organ Sharing, Richmond, VA, ²Thomas Jefferson University, Washington, DC, ³Tufts University, Medford, MA, ⁴Northwestern University, Chicago, IL
*Purpose: Kidneys are the most common organ involved in multi-organ transplants (MOT). MOT candidates often receive priority access to kidneys over single organ transplant (SOT)…
2019 American Transplant Congress
Differences in CMV-Specific CD4 T Cell Population in De Novo Kidney Transplant Recipients Treated with Everolimus-Based Regimen Compared to a Standard Tacrolimus-MPA Regimen: Results from ATHENA
I. A. Hauser¹, S. Marx¹, C. Sommerer¹, B. Suwelack¹, D. Dragun¹, O. Witzke¹, F. Lehner¹, I. Kroeger², M. Junge², F. Thaiss¹, B. Nashan¹, M. Sester¹
¹ATHENA, CMV Substudy Group, Germany, ²Novartis, Pharma GmbH, Germany
*Purpose: The ATHENA trial was designed to compare everolimus [EVR] in combination with tacrolimus [TAC] or cyclosporine A [CyA] vs. a standard regimen of mycophenolic…
2019 American Transplant Congress
Compatible Pairs in Paired Kidney Exchange – Are There Winners and Loosers?
V. Chipman¹, B. Lee¹, M. Cooper², M. C. Cuffy³, M. Ronin⁴, G. Hil⁴, S. Flechner⁵, A. Thomas⁶, D. A. Mandelbrot⁷, A. D. Waterman⁸, C. E. Freise¹, G. R. Roll¹
¹UCSF, San Francisco, CA, ²Georgetown Univ, Washington, DC, ³UC Hospital, Cincinnati, OH, ⁴NKR, Babylon, NY, ⁵Cleavland Clinic, Cleavland, OH, ⁶Johns Hopkins, Baltimore, MD, ⁷Univ of Wisconsin, Madison, WI, ⁸UCLA and Terasaki Research Institute, Los Angeles, CA
*Purpose: To understand patterns of participation for compatible pairs and their impact in increasing paired donation in a national registry.*Methods: Favorable pairs (FP) are defined…
2019 American Transplant Congress
Aorto-Iliac Calcification is a Risk Factor for Inferior Patient and Graft Survival in Kidney Transplant Recipients; A Systematic Review and Meta-Analysis
A. A. Rijkse, J. L. van Dam, H. J. Kimenai, J. N. IJzermans, R. C. Minnee
HPB/Transplant surgery, Erasmus Medical Center, Rotterdam, Netherlands
*Purpose: While the incidence of transplanting a kidney onto atherosclerotic iliac arteries is becoming more common, little is known about the clinical outcome. We performed…
2019 American Transplant Congress
Normothermic Ex-Vivo Kidney Perfusion Preservation Consistently Improves Extreme Marginal Graft Function Compared to Hypothermic Machine Perfusion
P. Urbanellis¹, M. Hamar¹, I. Linares¹, D. Kollmann¹, S. Ganesh¹, F. Oquendo¹, M. Sharma¹, R. John¹, A. Ghanekar¹, I. Mucsi¹, D. Bagli², A. Konvalinka¹, L. Robinson³, M. Selzner¹
¹Multi-Organ Transplantation Program, University Health Network, Toronto, ON, Canada, ²Division of Urology, The Hospital for Sick Children, Toronto, ON, Canada, ³Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: Normothermic ex-vivo kidney perfusion (NEVKP) is an emerging technique for renal graft preservation. We investigated whether NEVKP promoted improved marginal graft function compared to…
2019 American Transplant Congress
ABO Incompatibility in Kidney Transplantation Can Increase a Safety Margin of Epitope Mismatch Levels against De Novo DSA Production
T. Kobayashi¹, K. Iwasaki¹, M. Okada², K. Horimi¹, Y. Matsuoka¹, A. Takeda², N. Goto², S. Narumi², Y. Watarai²
¹Aichi Medical University School of Medicine, Nagakute, Japan, ²Nagoya Daini Red Cross Hospital, Nagoya, Japan
*Purpose: Chronic antibody-mediated rejection (cABMR) caused by de novo donor specific HLA antibodies (DSA) is one of major obstacles to long term graft outcome. ABO…
2019 American Transplant Congress
Heterozygous Gene Mutations In The Complement Factor I (cfi) Was Susceptibility Gene For The C3 Glomerulonephritis In Native Kidney And Renal Allograft
J. Wen, H. Song, X. Ni, M. Zhang, F. Xu, X. Zhu
Jinling Hospital, Nanjing University School of Medicine, National Clinical Research Center of Kidney Diseases, Nanjing, Jiangsu, China
*Purpose: We previously reported heterozygous c.848A > G and c.1339C > T gene mutations in the complement factor I (CFI) gene (NM_000204.3) in a kidney transplant recipient with C3…
2019 American Transplant Congress
The Polish Troubled Kidney Transplant Biopsy Study: External Validation of the Molecular Microscope System
M. Myślak¹, D. Deborska-Materkowska², M. Ciszek², J. Mazurkiewicz¹, A. Debska-Slizien³, P. F. Halloran⁴, A. Perkowska-Ptasińska⁵
¹Pomeranian Medical University, Szczecin, Poland, ²Warsaw Medical Univeristy, Warsaw, Poland, ³Gdansk Medical University, Gdansk, Poland, ⁴Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton AB, AB, Canada, ⁵Medical University of Warsaw, Warsaw, Poland
*Purpose: The transplant clinician frequently encounters kidney transplant biopsies that are difficult to interpret by histology. A Molecular Microscope Diagnostic System (MMDx) has been developed…