Articles tagged "Kidney transplantation"

2019 American Transplant Congress
Using an Electronic Medical Record Tool to Document Transplant Option Discussions among Patients with EGFR ≤ 20 mL/min/1.73m²
A. Yishak¹, R. R. Brentari², R. M. Love La Londe³, E. Clark⁴, E. Clark⁴, J. Sun⁵, S. Vupputuri⁶
¹Nephrology, MAPMG, Mc Lean, VA, ²KP National Transplant Service, Oakland, CA, ³KP National Transplant Services, Oakland, CA, ⁴KP National Transplant Services, silver spring, MD, ⁵KP, Rockville, MD, ⁶MAPRI, MAPMG, Rockville, MD
*Purpose: The purpose of this study, in a large integrated health system, was to improve: 1) the documentation of transplant option discussions by providers among…
2019 American Transplant Congress
Expression of Prostaglandin E2 Receptors Track with Rejection in Porcine Kidney Transplants
A. Harner¹, Y. Wang², X. Fang², R. Lassiter¹, T. D. Merchen¹, S. Ho³, S. Nahman Jr²
¹Surgery, Augusta University, Augusta, GA, ²Nephrology, Augusta University, Augusta, GA, ³Gift of Life Michigan, Ann Arbor, MI
*Purpose: Prostaglandin E2 (PGE2) is generated from arachidonic acid via cyclooxygenase-2 (COX2) and is known to modulate the immune response via its receptors: EP1, EP2,…
2019 American Transplant Congress
Pharmacological Mobilization of Host Stem Cells Prevents Delayed Graft Function Following Kidney Transplantation in Rats
W. Wang, L. Qi, J. Huang, A. Ahmadi, A. Krishnan, R. Wesson, A. Cameron, Z. Sun
Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Delayed graft function (DGF) caused by ischemia-reperfusion injury (IRI) is an early complication that occurs in nearly a quarter of all deceased-donor kidneys and…
2019 American Transplant Congress
Liquid Biopsy for Chronic Rejection after Kidney Transplantation. A Novel Non-Invasive Biomarker Involved in Inflammatory Amplifier
Y. Takada¹, D. Kamimura², H. Higuchi¹, D. Iwami¹, K. Hotta¹, N. Iwahara¹, N. Shinohara¹, M. Murakami²
¹Renal and Genitourinary Surgery, Hokkaido University Hospital, Sapporo, Japan, ²Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
*Purpose: In kidney transplantation (KTx), despite recent advances of medical technology, chronic rejection accounts for 25% of the graft loss. Chronic active antibody-mediated rejection (CAAMR)…
2019 American Transplant Congress
Lack of Response to Tocilizumab in Kidney Transplants with Chronic Antibody-Mediated Rejection
D. Kumar¹, F. Safavi¹, R. Sandhu¹, P. Halloran², I. Yakubu¹, M. Levy¹, I. Moinuddin¹, P. Kimball¹, L. Kamal¹, A. King¹, H. Massey¹, G. Gupta¹
¹Virginia Commonwealth University, Richmond, VA, ²Alberta Transplant Genomics Applied Centre, Edmonton, AB, Canada
*Purpose: Chronic antibody mediated rejection (cAbMR) is a major cause of long-term kidney transplant (KT) loss. Traditional therapies for cAbMR have unclear efficacy with significant…
2019 American Transplant Congress
Unifying Interpretation of Molecular HLA Typing Data between the Solid Organ Allocation Match Run and Virtual Crossmatch
N. Kaur¹, E. Kransdorf², M. Pando³, L. Gragert¹
¹Tulane University School of Medicine, New Orleans, LA, ²Cedars-Sinai Heart Institute, Los Angeles, CA, ³Baylor Scott & White, Temple, TX
*Purpose: Virtual crossmatch compares a transplant candidate’s HLA antibody assay results to the HLA typing of the donor before an organ offer is accepted. While…
2019 American Transplant Congress
The Effect of a Novel Dosing Protocol for the De Novo Use of LCP Tacrolimus in Kidney Transplant Recipients Managed on a Steroid-Free Maintenance Immunosuppression Regimen
R. Wolff¹, A. Nasstrom¹, C. Borscheid¹, C. Martin¹, A. Temelie¹, R. Spong², D. Keys², T. B. Dunn³
¹School of Pharmacy, MHealth U of MN Medical Center-Fairview, Mpls, MN, ²Medicine, MHealth U of MN Medical Center-Fairview, Mpls, MN, ³Surgery, U of Pennsylvania, Phila, PA
*Purpose: It is not known if an extended release formulation of tacrolimus (LCPT, Envarsus XR®) can be successfully dosed to achieve an early therapeutic trough…
2019 American Transplant Congress
Calcineurin Inhibitor Holiday for Management of Post Transplant Acute Kidney Injury
S. Sriperumbuduri, D. Lazarus, T. Fairhead, S. Hoar, J. Karpinski, G. Knoll
Nephrology, The Ottawa hospital, Ottawa, ON, Canada
*Purpose: Calcineurin inhibitors (CNI), despite dominating the armamentarium of post transplant medications, are associated with long term nephrotoxicity and also delayed recovery of renal function…
2019 American Transplant Congress
Respiratory Viral Infections and Patient Outcomes in Solid Organ Transplant Recipients
M. Gonzalez¹, A. Vostal¹, N. Darling², C. Papastamelos², M. Natarajan³, P. Kumar³, J. Timpone³
¹Internal Medicine, MedStar Georgetown University Medical Center, Washington, DC, ²School of Medicine, Georgetown University, Washington, DC, ³Infectious Disease, MedStar Georgetown University Medical Center, Washington, DC
*Purpose: Community acquired respiratory viral infections (RVI) have been associated with significant morbidity and mortality in solid organ transplant recipients (SOTR). Acute rejection and allograft…
2019 American Transplant Congress
Dissecting The Role Of Donor Acute Kidney Injury On Molecular Responses Post-transplantation
S. Bontha¹, D. Maluf¹, E. Akalin², L. Gallon³, J. Eason⁴, V. Mas⁵
¹UTHSC, Memphis, TN, ²Albert Einstein Medical College, Bronx, NY, ³Northwestern University, Chicago, IL, ⁴Director of Transplantation, Memphis, TN, ⁵Director of Transplant Research, Memphis, TN
*Purpose: In the current scenario of shortage of donor organs, kidneys with AKI are being used and outcome research reports show that the outcomes could…