Articles tagged "Kidney transplantation"

2019 American Transplant Congress
Kidney Paired Donation Transplant Outcomes: Experiences from the First Ten Years of the National Kidney Registry
D. B. Leeser¹, A. G. Thomas², A. A. Shaffer², J. Veale³, A. B. Massie², M. Cooper⁴, S. Kapur⁵, S. Kapur⁵, S. Kapur⁵, N. Turgeon⁶, D. Segev², A. Waterman³, S. Flechner⁷
¹East Carolina Univ Sch of Med, Greenville, NC, ²Johns Hopkins, Baltimore, MD, ³UCLA, Los Angeles, CA, ⁴Georgetown, Washington, DC, ⁵Weill Cornell Medical School, New York, NY, ⁶Emory, Atlanta, GA, ⁷Cleveland Clinic, Cleveland, OH
*Purpose: In the United States (US), kidney paired donation (KPD) networks have facilitated an increasing proportion of KTs annually, but longer-term transplant outcomes and differences…
2019 American Transplant Congress
Care of International Living Kidney Donor Candidates in the U.S.: A Survey of Contemporary Experience, Practice & Challenges
K. Lentine¹, M. Henderson², S. Rasmussen², E. Shukhman³, J. Hunt⁴, F. Al Ammary², V. Kumar⁵, D. Lapointe-Rudow⁴, H. Schaefer⁶, M. Cooper⁷, R. Hays⁸, M. Dunbar-Forrest⁹, A. Nishio-Lucar¹⁰, D. Mandelbrot⁸
¹Saint Louis Univ, Saint Louis, MO, ²Johns Hopkins, Baltimore, MD, ³Cedars Sinai, Los Angeles, CA, ⁴Mount Sinai, New York, NY, ⁵Univ Alabama, Birmingham, AL, ⁶Vanderbilt, Nashville, TN, ⁷Georgetown, Washington, DC, ⁸Univ Wisconsin, Madison, WI, ⁹UCLA, Los Angeles, CA, ¹⁰Univ Virginia, Charlottesville, VA
*Purpose: The evaluation and care of non-U.S. citizen, non-U.S. residents who wish to come to the U.S. to serve as living kidney donors (LKD) can…
2019 American Transplant Congress
Organ Resilience Contributes to Different Impact of Delayed Graft Function (DGF) on Graft Survival in Kidneys Donated by Brain Death (DBD) and Circulatory Death Donors (DCD)
M. J. de Kok, A. F. Schaapherder, L. G. Wijermars, D. K. de Vries, J. L. Lindeman
Transplantation Center, LUMC, Leiden, Netherlands
*Purpose: Despite a tripled higher incidence of DGF in DCD kidney grafts compared to DBD kidney grafts, large studies show equivalent long-term graft survival with…
2019 American Transplant Congress
Integrative Analysis of Immune Repertoire and Gene Expression from RNA-seq in Kidney Organ Transplants
S. Pineda¹, A. Ravoor², O. Bestard³, M. Sarwal¹, M. Sirota²
¹Department of Surgery, UCSF, San Francisco, CA, ²BCHSI, UCSF, San Francisco, CA, ³Department of Surgery, 3Bellvitge University Hospital, Barcelona, Spain
*Purpose: The main problem with kidney transplantation is the possibility of rejection, which is classified as either antibody-mediated rejection (AMR) or T-cell-mediated rejection (TCMR) depending…
2019 American Transplant Congress
Soluble C Type Lectin Receptor Protein Inhibition of Natural Killer Cell Mediated Tubular Epithelial Cell Death
S. Balaji¹, B. Fuhrmann², D. Lian³, H. Diao³, S. Ma³, Z. Zhang³, A. M. Jevnikar³
¹Physiology, Western University, London, ON, Canada, ²Microbiology and Immunology, Western University, London, ON, Canada, ³London Health Sciences Centre, London, ON, Canada
*Purpose: We have previously shown that Natural Killer (NK) cells can mediate kidney tubular epithelial cell (TEC) death and kidney ischemia-reperfusion injury (IRI) as well…
2019 American Transplant Congress
Rapid Detection of Kidney Transplant Injury by Quantifying Donor-Derived Cell-Free Deoxyribonucleic Acid via Massively Multiplex Polymerase Chain Reaction
T. K. Sigdel¹, F. Acosta², S. Navarro², B. Zimmermann², Z. P. Demko², S. Moshkevich², P. R. Billings², M. M. Sarwal¹
¹University of California San Francisco, San Francisco, CA, ²Natera Inc., San Carlos, CA
*Purpose: Plasma donor-derived cell-free DNA (dd-cfDNA) is a proven marker for allograft rejection in patients with kidney transplant (KT). Our goal was to assess performance…
2019 American Transplant Congress
Predicting Allograft Outcomes of Renal Transplantation with Pretransplant Metrics
J. Tchervenkov¹, M. Nguyen², S. Negi¹, S. Paraskevas¹
¹RIMUHC, Montreal, QC, Canada, ²SSM Health Saint Louis University Hospital, St. Louis, MO
*Purpose: Early allograft dysfunction as well as long-term graft loss are major obstacles to successful kidney transplantation. Currently, kidney donor risk index (KDRI) is used…
2019 American Transplant Congress
Graft Survival of Fourth Time Renal Transplant Recipients Are Similar to Third Time Transplants: A SRTR Database Analysis
B. Petrun, R. Nygaard, M. Hill, C. Richardson, A. Israni, P. Stahler
Hennepin County Medical Center, Minneapolis, MN
*Purpose: The number of candidates for repeat kidney transplant in the United States has steadily increased over the last 30 years. Second and third kidney…
2019 American Transplant Congress
The Effect Of Tacrolimus Trough Variability On Kidney Transplant Outcomes
S. Heeney¹, K. R. Szempruch¹, R. Lee¹, A. Mintz², P. Serrano¹, R. Detwiler¹, C. Doligalski¹
¹University of North Carolina Medical Center, Chapel Hill, NC, ²University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC
*Purpose: High variability in tacrolimus as assessed by tacrolimus coefficient of variability (TCV) in trough levels of kidney transplant recipients (KTRs) has been associated with…
2019 American Transplant Congress
Conversion to Belatacept in Kidney Transplant Recipients with Systemic Lupus Erythematosus
I. Carrión Barberà, M. C. Fajardo, D. Tsapepas, J. Gartshteyn, A. Askanase, H. E. Fernandez
Columbia University MC, New York, NY
*Purpose: Lupus nephritis (LN) results in the need for renal replacement therapy (RRT) in 10-30% of LN pts and 30% receive a kidney transplant (KT).…