Articles tagged "Kidney transplantation"

2019 American Transplant Congress
Achieving Robust Targeting of Antibody-Conjugated Nanoparticles Delivered during Ex Vivo Machine Perfusion of Human Kidneys
J. R. DiRito¹, S. Hosgood¹, M. L. Nicholson¹, G. Tietjen²
¹Surgery, University of Cambridge, Cambridge, United Kingdom, ²Surgery, Yale School of Medicine, New Haven, CT
*Purpose: In this study we seek to improve targeted nanoparticle (NP) delivery during ex-vivo normothermic machine perfusion through fibrinolysis for more homogenous treatment of human…
2019 American Transplant Congress
Assessment of the Relationship between Inflammation and Glomerular Filtration Rate
J. B. Ramirez-Gonzalez¹, L. E. Morales-BuenRostro², J. Furuzawa-Carballeda³, L. Garcia-Covarrubias⁴, R. L. Pacheco-Domínguez⁵, R. Durazo-Arvizu⁶, J. Alberu³, E. N. Cuevas-Medina⁷, M. López-Cervantes⁵, R. A. Osorio-Juárez⁵
¹Faculty of Medicine, Public Health Department, Universidad Nacional Autónoma de México, Mexico, Mexico, ²Department of Nephrology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico, ³Department of Transplantation, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico, ⁴Department of Transplantation, Hospital General de México Doctor Eduardo Liceaga, Mexico, Mexico, ⁵Faculty of Medicine, Department of Public Health, Universidad Nacional Autónoma de México, Mexico, Mexico, ⁶Department of Public Health Sciences, Loyola University Chicago, Chicago, IL, ⁷Department of Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico, Mexico
*Purpose: Since the inflammatory phenomena that occur after transplantation are decisive factors for developing renal rejection, we decided to study how the elevation of some…
2019 American Transplant Congress
Evidence to Support the Use of Kidney Allograft Function as a Clinical Trial Outcome Measure
M. Kadatz, J. Gill, S. Clark, J. S. Gill
Nephrology, University of British Columbia, Vancouver, BC, Canada
*Purpose: As a biomarker, kidney allograft function has been rejected as clinical trial outcome measure because it is not predictive of allograft survival. In this…
2019 American Transplant Congress
Impact Of The Provision Of Transplant Information On Access To First And Repeat Kidney Transplantation
S. Clark, A. Abdalla, M. Kadatz, J. Gill, J. S. Gill
Nephrology, University of British Columbia, Vancouver, BC, Canada
*Purpose: To determine whether the provision and relative impact of transplant information differs in incident ESRD patients and patients with a history of previous transplant…
2019 American Transplant Congress
Implementation of a De Novo Belatacept Protocol
D. Wojciechowski¹, M. Jacobs², K. Safa¹, H. Gilligan¹, H. Eliot¹, W. W. Williams, Jr¹
¹Massachusetts General Hospital, Boston, MA, ²Wake Forest, Winston-Salem, NC
*Purpose: The use of belatacept with basiliximab induction and maintenance MMF/prednisone when compared to cyclosporine is associated with superior long-term patient and graft survival but…
2019 American Transplant Congress
Belatacept Use in High Kidney Donor Profile Index Kidney Transplant Recipients
D. Britt¹, A. Gharabagi¹, K. Botkin¹, T. Horwedel², C. Carthon¹, J. Hagopian¹
¹Pharmacy, Barnes-Jewish Hospital, St. Louis, MO, ²Veloxis Pharmaceuticals, Cary, NC
*Purpose: To determine whether the use of belatacept is associated with renal function preservation in kidney transplant recipients from donors with a kidney donor profile…
2019 American Transplant Congress
Early Rejection Outcomes with IL-2 vs. ATG Induction among Kidney Transplant Recipients Induction Differences with Early Steroid Withdrawal
C. Burelli, A. Szczepanik, K. Yadav, E. Sanchez, M. Debroy, V. Humphreville, J. Rabets, A. Padiyar, N. Sarabu, A. Jittirat, A. Palanisamy, K. Chavin
University Hospitals Cleveland Medical Center, Cleveland, OH
*Purpose: Early steroid withdrawal in kidney transplant (Ktx) patients is controversial and has demonstrated an increased risk of acute rejection with similar long-term outcomes. Data…
2019 American Transplant Congress
Long-Term Exposure to Particulate Matter Air Pollution and the Risk of Graft Failure and Mortality in Kidney Transplant Recipients
Y. Kim¹, S. Kwon¹, J. Park², J. Lee³
¹Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ²Internal Medicine, Dongguk University Ilsan Hospital, Goyang, Korea, Republic of, ³Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea, Republic of
*Purpose: Elevated levels of fine particulate matter, 10 μm in aerodynamic diameter (PM10) are associated with increased risk of cardiovascular outcomes and death, but their…
2019 American Transplant Congress
Pre-Transplant Multidimensional Flow Cytometric Analysis of Kidney Transplant Recipients Reveals Novel Immune Signature of Allograft Rejection
P. Schroder¹, J. S. Yi¹, K. J. Weinhold¹, C. Chan², M. Joshi³, C. Walters³, J. Kwun¹, S. J. Knechtle¹
¹Department of Surgery, Duke University Medical Center, Durham, NC, ²Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, ³Substrate Services Core and Research Support, Duke University Medical Center, Durham, NC
*Purpose: Multicolor flow cytometry and multiplex assay platforms have revolutionized immune cell phenotyping and functional analyses, but these powerful tools have not demonstrated clinically meaningful…
2019 American Transplant Congress
The Association of Kidney Transplant Center Volume with 3-Year Outcomes
E. M. Sonnenberg¹, J. B. Cohen², J. Y. Hsu³, V. S. Potluri², M. H. Levine¹, P. L. Abt¹, P. P. Reese²
¹Surgery, University of Pennsylvania, Philadelphia, PA, ²Renal Division, University of Pennsylvania, Philadelphia, PA, ³Biostatistics, University of Pennsylvania, Philadelphia, PA
*Purpose: To assess if a center volume-outcome relationship exists for contemporary kidney transplantation, specifically in increased-risk scenarios including: diabetic recipients, elderly recipients (age>65) or recipients…