Articles tagged "Kidney transplantation"

2019 American Transplant Congress
Early T Cell Infiltration is Modulated by PD-1/PD-L1 Interactions in Kidney Graft
Y. Shim, R. Fan, N. Dvorina, W. Baldwin
Inflammation and Immunity, Lerner Research Institute, Cleveland, OH
*Purpose: Allogeneic transplants elicit dynamic T cell responses that are modulated by positive and negative co-stimulatory receptors. We have investigated the impact of PD-1, a…
2019 American Transplant Congress
Cost-Effectiveness Analysis of Renal Replacement Therapy Strategies in Haiti
J. S. Pyda¹, L. James², J. J. Kim², K. Khwaja¹, M. Shrime³
¹Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, ²Center for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA, ³Program in Global Surgery and Social Change, Harvard Medical School, Boston, MA
*Purpose: Kidney transplantation (KT) is the optimal renal replacement therapy (RRT) for patients with end-stage renal disease (ESRD) in high-income countries (HICs) conferring the highest…
2019 American Transplant Congress
Excellent Success with Safety and Efficacy of Direct-Acting Anti-Viral HCV Drugs in Kidney Transplant Recipients Using an Evolving Regimen. A Single Institution Experience
A. Sharfuddin, S. A. Hussain, T. Taber, D. Mishler, O. Adebiyi, M. S. Yaqub
Indiana University School of Medicine, Indianapolis, IN
*Purpose: Chronic Hepatitis C Virus (HCV) infection has a negative impact on graft survival. Prior treatments were poorly tolerated and had minimal cure rates. We…
2019 American Transplant Congress
Transplantation of Hepatitis C Virus Positive Donor Kidneys into Hepatitis C Negative Older Recipients
J. A. Graham¹, M. Ajaimy², J. Torabi¹, T. Powell³, J. Weiss⁴, T. Weinstein⁵, S. Greenstein¹, O. Andacoglu¹, A. Campbell⁶, J. Carrero¹, J. Lapponese¹, M. Kinkhabwala¹, E. Akalin², J. P. Rocca¹
¹Surgery, Montefiore Medical Center, Bronx, NY, ²Medicine, Montefiore Medical Center, Bronx, NY, ³Epidemiology and Psychiatry, Montefiore Medical Center, Bronx, NY, ⁴Medical Affairs, Montefiore Medical Center, Bronx, NY, ⁵Risk & Loss Prevention, Montefiore Medical Center, Bronx, NY, ⁶Pharmacy, Montefiore Medical Center, Bronx, NY
*Purpose: Patients awaiting transplantation are often at risk of developing life-threatening disease and complications. Older patients have a disproportionately higher risk of dropping out of…
2019 American Transplant Congress
TMA Development in Kidney and Heart Xenografts Treated with Anti-CD40 or Anti-CD154 Antibodies
D. H. Ma¹, H. Sasaki¹, J. M. O¹, K. Ahrens¹, D. Becerra¹, C. G. Rickert¹, D. M. Detelich¹, T. Oura¹, W. Somer¹, I. Rosales², R. N. Pierson¹, J. Markmann¹, J. C. Madsen¹, T. Kawai¹
¹Surgery, MGH, Boston, MA, ²Pathology, MGH, Boston, MA
*Purpose: Genetically modified Galactose-α 1,3-galactose knockout transgenic swine expressing human CD55 (GTKO.hCD55) are resistant to hyperacute rejection of xenografts. We compare anti-CD154 and anti-CD40 antibody-based…
2019 American Transplant Congress
CMV Risk Status Remains a Relevant Risk Factor for Long-Term Outcomes
G. Karadkhele, W. Zhang, C. P. Larsen
Emory University, Atlanta, GA
*Purpose: Intensification of immunosuppression using T cell depleting induction has reduced rates of acute cellular rejection after kidney transplantation. Belatacept, a first in class T…
2019 American Transplant Congress
Bortezomib Based Induction Therapy Decreases Delayed Graft Function in High Risk Kidney Transplantation
K. Mahendran¹, N. Koizumi², J. K. Melancon¹
¹Transplant Institute, The George Washington University, Washington, DC, ²Schar School of Policy and Government, George Mason University, Arlington, VA
*Purpose: Over 100,000 candidates await a kidney transplant on the national United Network for Organ Sharing (UNOS) waitlist. Among these candidates, one-third have pre-formed antibodies…
2019 American Transplant Congress
Antirejection Efficacy in De Novo Renal Transplant Recipients Receiving Everolimus with a Reduced-Exposure Calcineurin Inhibitor-Based Regimen: 24-Month Results from the TRANSFORM Study
H. Tedesco Silva¹, F. Citterio¹, M. Henry¹, T. R. Srinivas¹, Y. Watarai¹, S. Steinberg¹, N. Basic-Jukic¹, V. D. Garcia¹, E. Mor¹, V. R. Peddi¹, P. Narvekar², M. P. Hernandez Gutierrez², P. Bernhardt², J. Pascual¹
¹TRANSFORM Study Group, Basel, Switzerland, ²Novartis Pharma AG, Basel, Switzerland
*Purpose: To compare the antirejection efficacy outcomes of an everolimus+reduced-exposure CNI (EVR+rCNI) vs mycophenolic acid+standard-exposure CNI (MPA+sCNI) regimen in renal transplant recipients (RTxRs) from the…
2019 American Transplant Congress
Preemptive Kidney Transplantation: Is There a Role for ABO Incompatible Transplantation?
M. N. Mustian¹, B. A. Shelton¹, P. A. MacLennan¹, R. D. Reed¹, G. McGwin¹, B. J. Orandi¹, D. Sawinski², V. Kumar¹, J. E. Locke¹
¹University of Alabama at Birmingham, Birmingham, AL, ²University of Pennsylvania, Philadelphia, PA
*Purpose: Barriers to kidney transplantation (KT) exist, including ABO incompatibility (ABOi) between potential living kidney donors and transplant candidates. Incompatible pairs can undergo desensitization or…
2019 American Transplant Congress
A Single-Center Experience with a 6-Month Regimen of Pneumocystis jiroveci Pneumonia Prophylaxis in HIV-Positive Kidney Transplant Recipients
C. Mejia¹, G. Malat², D. H. Lee³, S. Epstein¹, M. Harhay³, L. Levin Mizrahi³, K. Ranganna³
¹Drexel University, Philadelphia, PA, ²Hahnemann University Hospital, Philadelphia, PA, ³Medicine, Drexel University, Philadelphia, PA
*Purpose: Pneumocystis jiroveci pneumonia (PJP) prophylaxis is recommended for all kidney transplant recipients (KTR) for after transplant. HIV-positive KTRs represent a unique subset, and there…