Articles tagged "Kidney transplantation"

2019 American Transplant Congress
Urinary Exosomal microRNA as a Non-Invasive Biomarker for the Diagnosis of Acute Rejection in Kidney Transplant Recipients
J. Seo¹, Y. Lee¹, S. Jung¹, Y. Kim¹, J. Moon¹, K. Jeong¹, C. Kim², J. Park³, B. Chung⁴, Y. Kim⁵, S. Lee¹
¹Nephrology, Kyung Hee University College of Medicine, Seoul, Korea, Republic of, ²Nephrology, Kyungpook National University College of Medicine, Daegu, Korea, Republic of, ³Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of, ⁴Nephrology, The St. Mary’s Hospital of Catholic University of Korea, Seoul, Korea, Republic of, ⁵Nephrology, Inje University College of Medicine, Busan, Korea, Republic of
*Purpose: Acute rejection (AR) is the main obstacle to the graft survival after kidney transplantation. Urinary exosome is a promising source of biomarker for various…
2019 American Transplant Congress
NK Cell Quantification by Paraffin Immunohistochemistry is Not Predictive of Graft Outcome in 1-Year Surveillance Biopsies
J. Barnes¹, F. Suliman², A. Shammout¹, E. A. Farkash¹
¹Pathology, Michigan Medicine, Ann Arbor, MI, ²Nephrology, Michigan Medicine, Ann Arbor, MI
*Purpose: Molecular and animal studies have identified NK cells as important mediators and markers of antibody mediated rejection. Using three color immunohistochemistry for CD16, T-bet,…
2019 American Transplant Congress
Increased Number of Intragraft FoxP3+ T Cells is Strongly Correlated with Decreased Graft Survival in Chronic Active Antibody Mediated Rejection
K. Sablik¹, K. Jordanova², M. Clahsen-van Groningen¹, M. Betjes¹
¹Erasmus MC, Rotterdam, Netherlands, ²Amsterdam UMC, Amsterdam, Netherlands
*Purpose: Chronic-active antibody-mediated rejection (c-aABMR) is the most important cause of late renal allograft failure. However, renal inflammation and rate of loss of renal allograft…
2019 American Transplant Congress
Estimated vs. Actual Graft Failure and Patient Survival after Kidney Transplantation
J. Buggs¹, T. Thigpen², E. Rogers¹, A. Kumar³, V. Bowers¹
¹Tampa General Hospital, Tampa, FL, ²Wesleyan College, Macon, GA, ³University of South Florida, Tampa, FL
*Purpose: The purpose of this study was to examine the difference between the estimated and actual values of graft survival and patient survival in kidney…
2019 American Transplant Congress
Evaluation of Envarsus XR in African American Kidney Transplant Recipients
L. R. Lineberger¹, E. Hollinger², N. Kenyon¹, M. Brokohf¹, N. Alvey¹
¹Pharmacy, Rush University Medical Center, Chicago, IL, ²Rush University Medical Center, Chicago, IL
*Purpose: This study is being conducted to evaluate the clinical impact of the utilization of tacrolimus LCP (TAC-LCP) compared to tacrolimus immediate release (TAC-IR) in…
2019 American Transplant Congress
Risk Factors for Initial Sub- and Supra-Therapeutic Tacrolimus Trough Levels in Renal Transplant Recipients
M. Kapugi, K. Cunningham, C. D'Agostino, C. Kane, A. Novak, J. Schulte
Northwestern Memorial Hospital, Chicago, IL
*Purpose: Sub-therapeutic tacrolimus trough levels have been associated with increased risk of rejection in renal transplant recipients and supra-therapeutic levels with infectious risks and drug…
2019 American Transplant Congress
Inhibition of TLR4 Mediated Programmed Necrosis Does Not Improve Graft Function and Histology in a Murine Kidney Transplant Model
S. Jain¹, R. Plenter², T. Nydam², A. Jani¹
¹Renal Division, University of Colorado, Aurora, CO, ²Transplant Microsurgery Program, University of Colorado, Aurora, CO
*Purpose: Human Delayed Graft Function (DGF) is associated with upregulation of basolateral tubular TLR4 but whether TLR4 causes DGF is unknown. TLR4 has been shown…
2019 American Transplant Congress
The Number of Donor-Specific IL-21 Producing Cells before and after Transplantation Predicts Kidney Graft Rejection
N. M. van Besouw¹, L. Yan¹, R. de Kuiper¹, M. Klepper¹, D. Reijerkerk¹, M. Dieterich¹, D. L. Roelen², F. H. Claas², M. C. Clahsen-van Groningen³, D. A. Hesselink¹, C. C. Baan¹
¹Internal Medicine - Nephrology & Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, ²Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, Netherlands, ³Pathology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
*Purpose: Interleukin (IL)-21 supports induction and expansion of CD8+ T cells, and can also regulate the differentiation of B cells into antibody-producing plasma cells. We…
2019 American Transplant Congress
Outcomes after Declining Increased Infectious Risk Kidney Offers for Pediatric Candidates in the United States
M. Bowring, K. Jackson, H. Wasik, A. Neu, J. Garonzik-Wang, C. Durand, N. Desai, A. Massie, D. Segev
Johns Hopkins University, Baltimore, MD
*Purpose: Kidneys from donors at increased infectious risk for disease transmission (IRDs) confer substantial survival benefit in adults, yet the impact of IRDs in pediatric…
2019 American Transplant Congress
Evaluation of Pretransplant Biopsy as a Influence Factor of Early Graft Function after Donated Kidney Transplantation
X. Qiuxiang, W. Zhendi
Urology Surgery, Wuhan Union Hospital, Wuhan, China
*Purpose: To investigate the relationship between pretransplant biopsy and the early graft function after donated kidney transplantation.*Methods: We examined pretransplant biopsies for 240 kidney transplant…