Articles tagged "Kidney transplantation"

2019 American Transplant Congress
Is Kidney Transplantation Actually a Cost-Effective Alternative Also for Older Patients?
K. Heldal¹, K. Lønning², V. Tsarpali¹, K. Midtvedt²
¹Clinic of Internal Medicine, Telemark Hospital Trust, Skien, Norway, ²Oslo University Hospital, Oslo, Norway
*Purpose: We aimed to study the health economic effects of kidney transplantation in a population of kidney transplant candidates > 65 years of age.*Methods: We…
2019 American Transplant Congress
Using Ensembles of Machine Learning Classifiers to Maximize the Accuracy and Stability of Molecular Biopsy Interpretation
J. Reeve¹, K. S. Madill-Thomsen², P. F. Halloran and the INTERCOMEX Study Group³
¹University of Alberta, Edmonton, AB, Canada, ²Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton AB, AB, Canada, ³University of Alberta, Edmonton AB, AB, Canada
*Purpose: The Molecular Microscope diagnostic system (MMDx), based on microarray gene expression, uses ensembles of machine learning classifiers rather than single genes, gene sets, or…
2019 American Transplant Congress
A 15-year Experience With Kidney Transplant In Undocumented Immigrants: Outcomes And An Argument For Transplantation
M. G. Janeway¹, A. Foster², S. De Geus¹, K. Curreri¹, T. Dechert¹, M. Nuhn¹, M. Nuhn¹
¹Surgery, Boston Medical Center, Boston, MA, ²Boston University School fo Medicine, Boston, MA
*Purpose: We investigated whether undocumented immigrants have similar outcomes after renal transplant compared to documented recipients.*Methods: We retrospectively analyzed records of adult renal transplant recipients…
2019 American Transplant Congress
Kidney Transplants Outcomes from Deceased Donors with Acute Kidney Injury
C. Jung¹, P. Sood², R. Mehta², D. Jorgensen², M. Molinari², S. Hariharan², A. Ganoza², D. Van Der Windt², M. Wijkstrom², C. Puttarajappa², A. Tevar³
¹Korea Univ. Anam Hospital, Seoul, Korea, Republic of, ²Univ. Pittsburgh Medical Center, Pittsburgh, PA, ³Department of Surgery, Univ. Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: Due to the shortage of organs for transplantation, kidney transplants (KT) from marginal donors including donors with acute kidney injury (AKI) are expanding. Although…
2019 American Transplant Congress
Predicting Transplant Rejection by a Composite Urinary Injury Score
J. Y. Yang, R. Sarwal, T. K. Sigdel, M. M. Sarwal
Department of Surgery, UCSF, San Francisco, CA
*Purpose: While sequencing or SNP-based methods of quantifying donor-derived cell-free DNA (dd-cfDNA) from plasma have been used to detect allograft rejection, they remain expensive and…
2019 American Transplant Congress
Global Kidney Exchange
D. N. Bozek¹, O. Ekwenna¹, S. Paloyo², T. Dunn³, K. Krawiec⁴, S. Rees⁵, A. Roth⁶, M. Zimmerman⁷, J. Punch⁸, R. Forbes⁹, C. Marsh¹⁰, C. Kuhr¹¹, J. Rogers¹², M. Tan¹³, L. Basagoitia¹⁴, R. Correa-Rotter¹⁵, J. Ortiz¹, P. Sindhwani¹, M. A. Rees¹
¹University of Toledo Medical Center, Toledo, OH, ²University of the Philippines – Philippine General Hospital; St. Luke’s Medical Center, Manila, Philippines, ³University of Minnesota, Minneapolis, MN, ⁴Duke University, Durham, NC, ⁵Alliance for Paired Donation, Perrysburg, OH, ⁶Stanford University, Stanford, CA, ⁷Froedert Hospital-Medical College of Wisconsin, Milwaukee, WI, ⁸University of Michigan, Ann Arbor, MI, ⁹Vanderbilt University Medical Center, Nashville, TN, ¹⁰Scripps Green Hospital, San Diego, CA, ¹¹Virginia Mason Medical Center, Seattle, WA, ¹²Wake Forest Baptist Medical Center, Winston-Salem, NC, ¹³Piedmont Hospital, Atlanta, GA, ¹⁴ProRenal, ., Mexico, ¹⁵INNSZ, Mexico City, Mexico
*Purpose: Poverty prevents more kidney transplants (KTs) worldwide than any other barrier. Global kidney Exchange (GKE) is a mechanism to overcome this barrier.*Methods: In high-income…
2019 American Transplant Congress
Positron Emission Tomography (PET-CT) Global Coronary Flow Reserve (CFR) Stratifies Cardiovascular Risk among Renal Transplant (RTx) Candidates
M. Minder, S. Mason, J. Ethington, R. McCubrey, D. Min, N. Sekaran, J. Orford, D. Morris, S. Anand, T. Srinivas
Intermountain Healthcare, Murray, UT
*Purpose: Chronic kidney disease (CKD) and diabetes (DM) are both associated with increased risk of coronary artery disease and Major Adverse Cardiovascular Events (MACE). The…
2019 American Transplant Congress
Differences of Gut Microbiota Composition between Donor and Recipient May Predict 1-Year Graft Function
J. Kim¹, H. Cho², J. Park³, J. Jeong¹, M. Kwak⁴, B. Kim⁴, D. Kim¹, J. Lee⁵, B. Kim⁶, Y. Kim¹, H. Lee¹
¹Seoul National University Hospital, Seoul, Korea, Republic of, ²Chungbuk National University Hospital, Cheongju, Korea, Republic of, ³Kangwon National University Hospital, Seoul, Korea, Republic of, ⁴Chunlab Inc., Seoul, Korea, Republic of, ⁵Seoul National University Boramae Hospital, Seoul, Korea, Republic of, ⁶Hallym University, Chuncheon, Korea, Republic of
*Purpose: Signals derived from gut microbiota are critical for the development and maintenance of the human immune system. In view of kidney transplantation (KT), allograft…
2019 American Transplant Congress
Three-Year Outcomes of Highly-Sensitized Kidney Transplant Recipients Desensitized with Imlifidase (IdeS)
E. Huang¹, J. Choi¹, A. Vo¹, A. Peng¹, R. Najjar¹, S. Sethi¹, C. Kjellman², L. Winstedt², N. Ammerman¹, S. C. Jordan¹
¹Cedars Sinai Medical Center, Los Angeles, CA, ²Hansa Medical, Lund, Sweden
*Purpose: The HLA-incompatible (HLAi) barrier has been traversed using desensitization therapies with IVIg, rituximab and/or plasmapheresis, although antibody-mediated rejection (ABMR) continues to be observed in…
2019 American Transplant Congress
Kidney Allograft Recipient Absence of Myeloperoxidase Decreases Donor-Specific Antibody Titers and Attenuates Antibody-Mediated Allograft Rejection
S. Miyairi, N. Dvorina, A. Valujuskikh, W. M. Baldwin 3rd, R. L. Fairchild
Immunology, Cleveland Clinic Lerner Institute, Cleveland, OH
*Purpose: The incidence of antibody-mediated kidney graft rejection continues to increase. We previously reported that dysregulated donor-specific antibody (DSA) responses were induced in B6.CCR5-/- mice…