ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Kidney transplantation"

  • 2019 American Transplant Congress

    Tertiary Lymphoid Organs in Renal Chronic Allograft Rejection

    K. Abou-Daya, D. Zhao, A. Williams, M. Oberbarnscheidt

    Starzl Transplantation Institute, Pittsburgh, PA

    *Purpose: Chronic allograft rejection remains a major obstacle to long-term allograft survival. Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in non-lymphoid tissues…
  • 2019 American Transplant Congress

    A Prospective Randomized Multicenter Trial (B E S T Trial) of Belatacept-Based C N I- and Corticosteroid-Free Immunosuppression: Final Two Year Results

    D. B. Kaufman1, A. R. Shields2, J. P. Leone3, A. Wiseman4, A. J. Matas5, P. West-Thielke6, J. Lipscomb2, E. King2, R. R. Alloway7, E. S. Woodle for the BEST Study Group2

    1University of Wisconsin, Madison, WI, 2University of Cincinnati, Cincinnati, OH, 3Tampa General, Tampa, FL, 4University of Colorado School of Medicine, Denver, CO, 5University of Minnesota, Minneapolis, MN, 6University of Illinois, Chicago, Chicago, IL, 7University of Cincinnati, Cincinnati, WI

    *Purpose: The BEST Trial (Belatacept-based Early Steroid Withdrawal Trial) is a prospective, randomized, multi-center trial designed to compare two belatacept (BELA)-based calcineurin inhibitor-free (CNI), early…
  • 2019 American Transplant Congress

    Increase in 48 Month Cumulative Acute Rejection Rates in the Most Recent Cohort: The 2018 Transplant Report of the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS)

    V. Dharnidharka1, C. Cramer2, A. Chua3, A. Moudgil4, K. Martz5, T. Blydt-Hansen6, J. Smith7, A. Neu, on Behalf of The NAPRTCS Investigators8

    1Washington University in St. Louis, Saint Louis, MO, 2Mayo Clinic, Rochester, MN, 3Duke University, Durham, NC, 4Children's National Medical Center, Washington, DC, 5Emmes Corporation, Rockville, MD, 6BC Children's Hospital, Vancouver, BC, 7Seattle Children's Hospital, Seattle, WA, 8Johns Hopkins University, Baltimore, MD

    *Purpose: The NAPRTCS registry has collected data on children receiving kidney transplants in North America since 1987. The registry has served to document and influence…
  • 2019 American Transplant Congress

    Tacrolimus Pharmacokinetics in Young, Middle Age and Older Renal Transplant Recipients- Impact of CYP3A5*3*6*7 Metabolic Composite

    K. Tornatore1, K. Attwood2, D. Brazeau3, R. Venuto4

    1University at Buffalo; School of Pharmacy, Buffalo, NY, 2Biostatistics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 3Marshall University; School of Medicine, Huntington, WV, 4University at Buffalo; School of Medicine, Buffalo, NY

    *Purpose: In spite of increased renal transplantation in patients over 60 years and the need for age-adjusted tacrolimus maintenance immunosuppression, limited pharmacokinetic comparisons between young,…
  • 2019 American Transplant Congress

    Impact of Race and Substance Use on Listing Decisions for Kidney Transplant

    R. N. DeBlasio1, L. Myaskovsky2, K. Kendall1, A. DiMartini1, G. Switzer1, D. M. Posluszny1, C. Puttarajappa1, A. D. Tevar1, S. Hariharan1, R. Shapiro3, M. A. Dew1

    1U Pittsburgh, Pittsburgh, PA, 2U New Mexico, Albuquerque, NM, 3Mt Sinai Recanati/Miller Transplantation Institute, New York, NY

    *Purpose: Racial/ethnic minority patients face reduced access to kidney transplantation. We hypothesized that this disparity may be magnified if patients also have major psychosocial liabilities…
  • 2019 American Transplant Congress

    Extracellular Vesicles (EV) Mediate Antibody-Independent Tubular Senescence via Cyclin-Dependent Kinase Inhibitors p21/p16 in Antibody-Mediated Rejection (AMR)

    C. Divella1, A. Stasi1, R. Franzin1, F. Sallustio2, C. Curci1, G. Merlotti3, M. Quaglia3, L. Gesualdo1, V. Cantaluppi1, G. Castellano1

    1Emergency and Organ Transplantation, University of Bari, Bari, Italy, 2Emergency and Organ Transplantation / Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, Bari, Italy, 3Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy

    *Purpose: Recent data suggest a strong correlation between kidney injury and the occurrence of accelerated senescence process, known as “Inflammaging”. However, the role of TEC…
  • 2019 American Transplant Congress

    Patient Centered AUC-Monitoring of Tacrolimus Using Capillary Microsampling

    M. T. Gustavsen, K. Midtvedt, N. Vethe, S. Bergan, A. Åsberg

    Oslo University Hospital, Rikshospitalet, Oslo, Norway

    *Purpose: To reduce unwanted side effects of Tacrolimus (Tac), improvement of dosing is warranted. Therapeutic drug monitoring (TDM) of Tac based on trough concentrations (C0)…
  • 2019 American Transplant Congress

    Basiliximab versus T-cell Depleting Induction Therapy in Elderly Kidney Transplant Recipients

    G. Vranic, H. Shah, B. Thomas, B. Javaid, J. Moore, M. Cooper, A. Gilbert

    MedStar Georgetown Transplant Institute, Washington, DC

    *Purpose: The ideal induction therapy for elderly kidney transplant recipients is not known. Given concerns about increased risk of infection and malignancy and perceived decreased…
  • 2019 American Transplant Congress

    Development of a Pharmacy Collaborative Practice Agreement to Improve Efficiency and Management of Prescribing in a Renal Transplant Clinic

    R. Chelewski1, K. Johnson1, A. Zuckerman2, J. DeClercq3, L. Choi3, M. Peter2, A. J. Langone4

    1Vanderbilt Specialty Pharmacy Services, Vanderbilt Univ Medical Ctr, Nashville, TN, 2Department of Pharmacy, Vanderbilt Univ Medical Ctr, Nashville, TN, 3Department of Biostatistics, Vanderbilt Univ Medical Ctr, Nashville, TN, 4Division of Nephrology, Vanderbilt Univ Medical Ctr, Nashville, TN

    *Purpose: This study describes the development of a Collaborative Pharmacy Practice Agreement (CPPA) between transplant pharmacists and physicians and assesses change in prescription volume and…
  • 2019 American Transplant Congress

    Timing and Donor-Specific Antibodies, but Not C4d Deposition, Determine Leukocyte Infiltration in Renal Allograft Biopsies with the Histological Picture of Antibody-Mediated Rejection

    J. Callemeyn1, A. Senev1, E. Lerut2, M. Coemans1, D. Kuypers1, W. Gwinner3, M. Essig4, D. Anglicheau5, P. Marquet6, M. Naesens1

    1Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium, 2Department of Pathology, University Hospitals Leuven, Leuven, Belgium, 3Department of Nephrology, Hannover Medical School, Hannover, Germany, 4Department of Nephrology, Dialysis and Transplantation, University of Limoges, Limoges, France, 5Necker-Enfants Malades Institute, French National Institute of Health and Medical Research U1151, Paris, France, 6U850 INSERM, University of Limoges, Limoges, France

    *Purpose: Diagnosis of antibody-mediated rejection following kidney transplantation can be challenging, given the limited specificity of individual histological parameters and time-dependent occurrence of histological confounders.…
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