Articles tagged "Kidney transplantation"

2019 American Transplant Congress
Newly-Revealed Antibody Targets Lead to the Early Loss of Triple Knockout Pig Kidneys in a Pig to Baboon Model
Y. Ariyoshi¹, K. Takeuchi¹, T. Pomposelli¹, D. K. Ekanayake-Alper¹, C. Schuetz¹, H. Sahara¹, L. Boyd¹, E. Estime¹, S. Arn¹, D. Ayares², M. Lorber³, M. Sykes¹, D. Sachs¹, K. Yamada¹
¹CCTI/Surgery, Columbia University Medical Center, New York, NY, ²Revivicor Inc., Blacksburg, VA, ³Lung BioTechnology PBC, Silver Spring, MD
*Purpose: We have achieved >6 months survival of a life-supporting kidney with a vascularized thymus (VT) in a pig-to-baboon model. While improved survival has been…
2019 American Transplant Congress
Comparative Analysis of Belatacept and Mycophenolate Monotherapy-Based Regimens for HLA Identical Living Donor Kidney Transplantation
M. Yamada, K. Meganathan, A. Shields, P. Brailey, S. Tremblay, A. Govil, R. R. Alloway, S. Shah, E. S. Woodle, B. G. Abu Jawdeh
Univ. of Cincinnati, Cincinnati, OH
*Purpose: HLA identical (HLA ID) living donor kidney transplants (KTx) provide long-term survival with substantially reduced rejection risk; aspects that can be exploited in designing…
2019 American Transplant Congress
Antithymocyte Globulin is Associated with Mature T Cell Phenotypes and Decreased Risk of Non-EBV Infections in Transplanted Children
B. I. Shaw¹, L. Stempora¹, C. Chan¹, R. B. Ettenger², P. C. Grimm³, H. Lee¹, E. F. Reed², M. M. Sarwal⁴, B. L. Warshaw⁵, C. Zhao¹, O. M. Martinez³, A. D. Kirk¹, E. T. Chambers¹
¹Pediatrics/Surgery, Duke University, Durham, NC, ²Pediatrics, University of California, Los Angeles, Los Angeles, CA, ³Pediatrics/Surgery, Stanford University, Palo Alto, CA, ⁴Pediatrics/Surgery, University of California, San Francisco, San Francisco, CA, ⁵Pediatrics, Emory University, Atlanta, GA
*Purpose: Depletional induction therapies are known to reduce the rate of acute rejection; yet data from the US Renal Data System have shown that use…
2019 American Transplant Congress
Association Of Kdpi And Dgf With Dcd Kidney Transplants Outcomes
M. Sampaio, B. Abdalla, S. Bunnapradist
David Geffen Sch of Med at UCLA, Los Angeles, CA
*Purpose: Donors of circulatory death (DCD) have similar outcomes compared to donors of brain death (DBD) in kidney transplants. It is unclear if this is…
2019 American Transplant Congress
Living Kidney Donors Who Lose Weight in Order to Be Able to Donate, Gain More Weight after Donation
S. R. Punjala, L. Silas, R. Gokmen, N. Karydis
Department of Nephrology, Renal Transplant and Urology, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom
*Purpose: Living donor kidney transplantation is widely accepted to be the treatment of choice for end-stage kidney disease, and great efforts are undertaken to expand…
2019 American Transplant Congress
A Randomized, Controlled, Trial of Interventions to Promote Walking after Abdominal Organ Transplantation: The LIFT Study
M. Serper¹, I. Barankay², S. Chadha¹, J. Shults³, P. Reese¹
¹University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ²Wharton School, University of Pennsylvania, Philadelphia, PA, ³Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA
*Purpose: Substantial weight gain and sedentary behavior are common after transplantation. Behavioral economic strategies with financial incentives and reminders may promote healthy behaviors in the…
2019 American Transplant Congress
Deceased-Donor Acute Kidney Injury Associates with Less BK Viremia in Kidney Transplant Recipients
I. E. Hall, P. P. Reese, S. G. Mansour, S. Mohan, M. D. Doshi, Y. Jia, H. R. Thiessen-Philbrook, E. Akalin, M. N. Harhay, T. Muthukumar, B. Schröppel, P. Singh, F. L. Weng, J. S. Bromberg, C. R. Parikh
For the DDS Consortium, Baltimore, MD
*Purpose: BK viremia (BKV) and polyomavirus nephropathy are kidney transplant complications that contribute to morbidity and graft loss, and prior studies suggest they may be…
2019 American Transplant Congress
Significantly High FOXP3 mRNA in the Renal Allograft as a Mechanism of Tolerance Induced by Transient Mixed Chimerism in Non-Human Primates
M. Matsunami¹, I. Rosales¹, T. Oura¹, B. Adam², M. Mengel², R. Smith¹, A. Cosimi¹, R. Colvin¹, T. Kawai¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
*Purpose: Treg-rich organized lymphoid structures (TOLS) has been identified in recipients with renal allograft tolerance induced by transient mixed chimerism in non-human primates (NHPs) and…
2019 American Transplant Congress
Racial and Income-Based Disparities in Access to Kidney Transplantation in the Context of a Nationally-Financed Health System in Brazil
A. Saha¹, G. Ferreira², Y. Yu¹, M. Waldram¹, V. Colares², J. Bastos², M. Henderson¹, D. Segev¹, A. Massie¹
¹Surgery, Johns Hopkins School of Medicine, Baltimore, MD, ²Santa Casa de Misericordia de Juiz de Fora, Juiz de Fora, Brazil
*Purpose: Changes in economic and social factors in low- and middle-income countries have led to rising burden of chronic disease. Brazil, a middle-income country with…
2019 American Transplant Congress
IgG Glycosylation Causes Podocyte Injury in Transplant Glomerulopathy through Calcium Calmodulin Kinase IV
R. Bhargava, K. Maeda, M. Pavlakis, G. Tsokos
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
*Purpose: Transplant glomerulopathy(TG) is a major cause of late allograft loss. Increase in urine podocin/creatinine ratio in TG signifies acceleration of podocyte detachment from glomerular…