Articles tagged "Kidney transplantation"

2022 American Transplant Congress
Deep Phenotyping Methods Highlight Recipient-Derived CD16+ NK and CD16+ Monocyte Infiltration During Kidney Transplant Rejection
B. Lamarthée¹, J. Callemeyn¹, P. Koshy², T. Debyser³, E. Van Loon¹, A. Franken⁴, T. Van Brussel⁴, I. Arijs⁴, D. Lambrechts⁴, A. Senev¹, T. Vaulet⁵, C. Tinel¹, M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²Department of Morphology and Molecular Pathology, University Hospitals Leuven, Leuven, Belgium, ³Faculty of Medicine, KU Leuven, Leuven, Belgium, ⁴Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium, ⁵ESAT Stadius Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium
*Purpose: How the immune system participates to kidney transplant rejection has not been fully elucidated. Single-cell (sc) genomics techniques are revolutionizing our ability to characterize…
2022 American Transplant Congress
Plasmapheresis Dependent AT1R Antibody Associated Recurrent FSGS After Living Donor Kidney Transplantation
R. K. Mallavarapu
Transplant Nephrology, Augusta University - Medical College of Georgia, Augusta, GA
*Purpose: Antibodies against Angiotensin II type 1 receptors (AT1R-Abs) may predispose to podocyte injury, glomerular endotheliosis and proteinuria. The management of AT1R-Ab associated recurrent FSGS…
2022 American Transplant Congress
Treatment of BK Virus with Weekly Intravenous Immunoglobulin in Adult Kidney Transplant Recipients
G. Girone¹, W. Asch²
¹Department of Pharmacy, Yale New Haven Hospital, New Haven, CT, ²Section of Nephrology, Yale School of Medicine, New Haven, CT
*Purpose: The typical management of Polyoma BK virus (BKV) in kidney transplant recipients (KTR) includes reducing immunosuppression (IS). Intravenous immunoglobulin (IVIG) has been utilized for…
2022 American Transplant Congress
The Perspective of General Nephrologists Toward Transitions of Care and Management of Patients with Failing Kidney Allografts
T. Alhamad¹, H. Murad¹, D. Dadhania², M. Pavlakis³, S. Parajuli⁴, B. P. Concepcion⁵, N. Singh⁶, N. Murakami⁷, M. Casey⁸, M. Ji¹, M. Lubetzky⁹, E. Tantisattamo¹⁰, O. Alomar¹, A. Faravardeh¹¹, C. Blosser¹², A. Basu¹³, M. Molnar¹⁴, G. Gupta¹⁵, J. T. Adler¹⁶, D. Adey¹⁷, K. J. Woodside¹⁸, R. Parsons¹³, K. Lentine¹⁹
¹Wash U in St. Louis, Saint Louis, MO, ²Weill Cornell Med, New York, NY, ³Beth Israel, Boston, MA, ⁴U of Wisconsin, Madison, WI, ⁵Vanderbilt U, Nashville, TN, ⁶Northwell Health, Great neck, NY, ⁷Brigham and Women, Boston, MA, ⁸MUSC, Charleston, SC, ⁹Weill Cornell Medicine, New York, NY, ¹⁰UCI, Orange, CA, ¹¹SHARP, San Diego, CA, ¹²U of Washington, Seattle, WA, ¹³Emory U, Atlanta, GA, ¹⁴U of Utah, Salt Lake City, UT, ¹⁵VCU, Richmond, VA, ¹⁶Surgery, Brigham and Women, Boston, MA, ¹⁷UCSF, San Francisco, CA, ¹⁸U of Michigan, Ann Arbor, MI, ¹⁹Saint Louis U, Saint Louis, MO
*Purpose: Failing kidney allograft with subsequent return to dialysis is associated with high risk of morbidity and mortality. This project aimed to examine general nephrologist…
2022 American Transplant Congress
Regulatory T Cells Suppress Memory IL-17a Production in Highly Sensitised Patients with End-Stage Renal Disease
C. Dudreuilh¹, S. Basu¹, O. Shaw², H. Burton¹, C. Domingo-Vila¹, T. Tree¹, G. Lombardi¹, C. Scotta¹, A. Dorling¹
¹King's College London, London, United Kingdom, ²Viapath Clinical Transplantation Laboratory, Guy's Hospital, London, United Kingdom
*Purpose: Highly sensitised patients exhibit poorer long-term outcomes following renal transplantation compared to those non sensitised individuals. IL17-A has been associated with acute rejection. Presence…
2022 American Transplant Congress
Post-Kidney Transplant Dementia Risk by Modifiable Risk Factors and CNIs Among Older Recipients
Y. Chen¹, J. Ahn¹, N. Chu¹, S. Bae¹, M. A. Schnitzler², G. Hess³, K. Lentine⁴, D. Segev⁵, M. McAdams-DeMarco¹
¹Johns Hopkins School of Medicine, Baltimore, MD, ²Surgery, Saint Louis University, O Fallon, IL, ³Drexel University School of Medicine, Philadelphia, PA, ⁴Saint Louis University, St. Louis, MO, ⁵Johns Hopkins University, Baltimore, MD
*Purpose: Up to 17% of older recipients develop dementia after kidney transplant (KT). While there are known modifiable risk factors for dementia among community-dwelling older…
2022 American Transplant Congress
First-in-human Study Of Lis1, A Novel Glyco-humanized Anti-lymphocyte Swine Polyclonal Antibody, In Kidney Transplantation: Safety And Efficacy
J. Slatinska¹, B. Vanhove², M. Kolarova¹, F. Shneiker², J. Rousse², C. Galli³, J. Bach⁴, E. Cozzi⁵, J. Soulillou⁶, O. Duvaux², O. Viklicky¹
¹Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ²Xenothera, Nantes, France, ³Laboratorio di Tecnologie della Riproduzione, Cremone, Italy, ⁴IECM, Immunoendocrinology, USC1383, Oniris, INRAE, Nantes, France, ⁵Transplantation Immunology Unit, Padua University Hospital, Padova, Italy, ⁶Nantes Universités, Nantes, France
*Purpose: to assess safety, T cell depletion, PK/PD and determine the therapeutic dose of LIS1, a purified anti-lymphocyte glyco-humanized polyclonal swine IgG, derived by immunizing…
2022 American Transplant Congress
Conversion to Belatacept for Calcineurin Inhibitor Toxicities
S. S. Patel, P. Jadav, M. Sekulic, S. Kudose, I. Batal, S. Mohan, R. Crew
Columbia University Medical Center, New York, NY
*Purpose: Calcineurin inhibitors (CNIs) have improved renal transplant (RTx) outcomes but are associated with significant toxicities. Belatacept provides better long-term outcomes than cyclosporine, has less…
2022 American Transplant Congress
Performance of 2021 Creatinine and Cystatin C Based Equations without Race in Living Kidney Transplant Donors
A. Liaqat, H. Sawaf, L. Cholin, S. Arrigain, A. Wee, J. Schold, J. Augustine, E. Poggio
Cleveland Clinic, Cleveland, OH
*Purpose: New 2021 Creatinine (Cr) and Cystatin C (CysC) based GFR equations without the race factor have been refitted to perform better than either 2009…
2022 American Transplant Congress
Predicted Performance of Bayesian-Based Precision Dosing Software for Tacrolimus
A. Seghezzo¹, J. Kerr¹, A. Gupta², A. Ta², L. Powell², A. Feist³
¹University of California San Diego Health, San Diego, CA, ²PrecisePK, San Diego, CA, ³UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, CA
*Purpose: Bayesian-based precision dosing software (BPDS) has been utilized for therapeutic drug monitoring to optimize medication use. However, BPDS for tacrolimus (TAC) is not routinely…