Articles tagged "Kidney transplantation"

2019 American Transplant Congress
Hepatitis C Antibody Positive (HCV Ab+)/Nucleic Acid Test Negative (NAT -) Deceased Donor Kidney Transplantation into Hepatitis C Negative (HCV -) Recipients: Is It Safe?
Y. Taehwan, A. Rajab, G. Bumgardner, t. Pesavento, R. Daloul, A. Michaels, K. Washburn, A. El-Hinnawi
Ohio State University, Columbus, OH
*Purpose: Kidneys procured from HCV Ab+/NAT - are not routinely used due to concern for HCV transmission into recipients. However, there has been no report…
2019 American Transplant Congress
Post-Transplant Cancer and Graft Failure in Kidney Transplant Recipients
J. Kim, J. Ha, S. Min, H. Lee, Y. Kim, S. Han
Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: As the long-term patient survival and graft survival rate are gradually increasing in kidney transplant (KT) recipients, the importance of cancer occurrence and proper…
2019 American Transplant Congress
Immune Cells Composition of Humanized Mouse Kidney Compared to Normal Human Kidney
S. Noel¹, J. T. Kurzhagen¹, S. Lee¹, M. Sadasivam², A. R. Hamad², P. M. Pierorazio³, H. Rabb¹
¹Medicine, Johns Hopkins University, Baltimore, MD, ²Pathology, Johns Hopkins University, Baltimore, MD, ³Urology, Johns Hopkins University, Baltimore, MD
*Purpose: Most clinical studies fail in spite of promising mouse studies, in part due to fundamental differences between mice and human responses. Attempts have been…
2019 American Transplant Congress
Bcl-2 Inhibition with Venetoclax Promotes Induction of Mixed Chimerism and Renal Allograft Tolerance without Severe Myelosuppression in Non-Human Primate
H. Sasaki¹, D. Ma¹, T. Oura¹, A. Dehnadi¹, I. Rosales², B. Cosimi¹, P. Cippa³, T. Fehr³, T. Kawai¹
¹Surgery, Massachusetts General Hospital, Boston, MA, ²Pathology, Massachusetts General Hospital, Boston, MA, ³Medicine, University of Zurich, Zurich, Switzerland
*Purpose: Specific Bcl-2 inhibition has been shown to promote mixed chimerism and skin allograft tolerance without myelosuppressive conditioning in murine models. To extend this approach…
2019 American Transplant Congress
Evaluation of the Safety and Tolerability of Clazakizumab® (Anti-IL-6 Monoclonal) as a Desensitization Agent in Highly-HLA Sensitized ESRD Patients (nct03380962)
A. A. Vo, N. Ammerman, E. Huang, A. Peng, R. Najjar, S. Sethi, S. Williamsons, C. Myers, K. Lim, J. Choi, S. C. Jordan
Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: Currently, there is growing interest in development of novel immune-modulatory drugs likely to improve allo-antibody reduction in transplantation. Clazakizumab (Vitaeris Inc.) is a humanized…
2019 American Transplant Congress
Impact of Immunosuppressive Drug Withdrawal on Persistent Mixed Chimerism in Recipients of HLA Haplo-Identical Kidney and Hematopoietic Cell Transplants
S. Busque, J. Scandling, R. Lowsky, J. Shizuru, E. Meyer, K. Jensen, A. Shori, R. Hoppe, E. Engleman, S. Strober
Stanford University School of Medicine, Stanford, CA
*Purpose: We assessed the impact of the hematopoietic cell dose and the immunosuppressive drug (IS) withdrawal on the persistence of mixed chimerism after combined HLA…
2019 American Transplant Congress
Kinetics of Pretransplant DSA, Post-Transplant Histology, and Graft Failure after Kidney Transplantation
A. Senev¹, E. Lerut², V. Van Sandt³, J. Callemeyn¹, M. Coemans¹, B. Sprangers², D. Kuypers², M. Emonds¹, M. Naesens²
¹Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium, ²University Hospitals Leuven, Leuven, Belgium, ³Histocompatibility and Immunogenetics Laboratory, Belgian Red Cross-Flanders, Mechelen, Belgium
*Purpose: The association between the kinetics of pretransplant DSA levels and outcome after kidney transplantation is currently not well known. In this large cohort study…
2019 American Transplant Congress
Successful Kidney Transplantation of Highly Sensitized Candidates across Positive Cross Match and Strong Donor-Specific HLA-DP Antibodies without Desensitization
R. Rajalingam¹, D. D. Gae², Z. G. Laszik³, M. M. Tavakol⁴, A. B. Webber⁵, K. Cunniffe², G. da Gente², R. Hirose⁴, G. Roll⁴, C. E. Freise⁴, J. P. Roberts⁴
¹Immunogenetics and Transplantation Laboratory (ITL), San Francisco, CA, ²Department of Surgery, Immunogenetics and Transplantation Laboratory (ITL), San Francisco, CA, ³Department of Pathology, University of California San Francisco, San Francisco, CA, ⁴Department of Surgery, University of California San Francisco, San Francisco, CA, ⁵Department of Medicine, University of California San Francisco, San Francisco, CA
*Purpose: Over 50% of kidney transplant (Ktx) candidates with 100% CPRA display HLA-DP antibodies, which impair the chances of finding a compatible deceased donor (DD)…
2019 American Transplant Congress
Impact Of Cold And Warm Ischemia Time On Outcomes For Kidneys Donated After Cardiac Death
C. Brennan¹, P. R. Sandoval², S. A. Husain², D. Tsapepas¹, S. Mohan², L. E. Ratner²
¹New York Presbyterian, New York, NY, ²Columbia University Medical Center, New York, NY
*Purpose: Donors after cardiac death (DCD) organs are frequently being discarded. Prolonged warm (WIT) cold (CIT) ischemia times are often important considerations in the discard…
2019 American Transplant Congress
Apoptosis during Cold Ischemia and Rewarming Involves a Caspase Independent Pathway
S. Jain¹, R. Plenter², T. Nydam², A. Jani¹
¹Renal Division, University of Colorado, Aurora, CO, ²Transplant Microsurgery Program, University of Colorado, Aurora, CO
*Purpose: We have previously shown that hibernating ground squirrels (GS) tolerate core body temperatures of 4°C for several days with a heart rate that is…