Articles tagged "Kidney transplantation"

2019 American Transplant Congress
B Cell-Specific IRE1a Deficiency Protects Renal Allografts from Rejection via Inhibition of Donor-Specific Antibodies and Induction of B Regulatory Cells
L. Qiu¹, J. Wang¹, X. Yeap¹, D. Fang², Z. J. Zhang¹
¹Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, ²Department of Pathology, Northwestern University, Chicago, IL
*Purpose: Despite the progress in immunosuppressive regimens, antibody-mediated rejection remains a major contributor to renal allograft loss in recipients with donor-specific antibodies (DSA). IRE1a, an…
2019 American Transplant Congress
An International Comparison of Kidney Utilization in the United States and United Kingdom: What Can Be Learned?
D. Stewart¹, G. Vece¹, M. Ibrahim², C. Callaghan²
¹UNOS, Richmond, VA, ²NHS, London, United Kingdom
*Purpose: International discussions in 2017 about kidney “discard rates” between transplant (TX) professionals in the US and UK led to the realization that the two…
2019 American Transplant Congress
OPO Aggressiveness Index: A Novel OPO Performance Metric That Incentivizes Pursuit of Marginal Deceased Donor Candidates
L. Liyanage, Y. Yu, K. Jackson, J. Garonzik-Wang, D. Segev, A. Massie
Johns Hopkins, Baltimore, MD
*Purpose: Of 2.5M deaths in the US every year, only 10,000 are recovered for transplantation; recovery of organs from older donors is rare although similar…
2019 American Transplant Congress
6-Minute Walk Testing in Patients on the Kidney Transplant Waitlist
X. S. Cheng¹, J. Lee², K. V. Discipulo¹, J. Myers³, J. C. Tan¹
¹Nephrology, Stanford University, Palo Alto, CA, ²Kidney Transplant, Stanford Hospital, Palo Alto, CA, ³Cardiology, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA
*Purpose: Poor physical function in kidney transplant candidates is associated with frailty, sub-optimal transplant outcomes, and higher health care utilization. We need an instrument to…
2019 American Transplant Congress
Advanced Immunological T-cell Ageing Defined by a Very Low Thymic Function Identifies Patients with a Substantial Increased Risk for Long-Term Mortality after Kidney Transplantation
M. G. Betjes, A. Langerak, M. Klepper, N. Litjens
Nephrology & Transplantation, Erasmus MC, Rotterdam, Netherlands
*Purpose: End-stage renal disease is associated with premature ageing of the T-cell immune system. At the time of kidney transplantation the average biological age of…
2019 American Transplant Congress
Unos Analysis Of Deceased Donor Renal Transplant (ddrtx) Outcomes In Sensitized Patients After Implementation Of The Kidney Allocation System (kas)
R. J. Crew, K. L. King, M. Fajardo, J. Hedvat, N. Lange, S. Husain, S. Mohan, L. E. Ratner, S. S. Patel
Columbia University Irving Medical Center, New York, NY
*Purpose: Introduction of KAS in 2014 prioritized access to DDRTx for highly-sensitized candidates although it was unclear whether the outcomes would be acceptable in this…
2019 American Transplant Congress
Economic Impact of Donor Hepatitis C Kidney Transplantation: A Medicare Cost Analysis
K. Lentine¹, M. Schnitzler², T. Alhamad³, H. Xiao², H. Randall², J. Wellen², B. Kasiske⁴, G. Hess⁵, D. Axelrod⁶
¹Saint Louis University Medical Center, St. Louis, MO, ²Saint Louis Univ, St. Louis, MO, ³Washington Univ, St. Louis, MO, ⁴SRTR, Minneapolis, MN, ⁵Univ of Pennsylvania, Philadelphia, PA, ⁶Univ of Iowa, Iowa City, IA
*Purpose: In the era of highly effective direct-acting antiviral agents (DAAs), kidney transplant (KT) from Hepatitis C virus (HCV)-positive donors is increasingly considered as an…
2019 American Transplant Congress
Kidney Paired Donation Transplant Outcomes: Experiences from the First Ten Years of the National Kidney Registry
D. B. Leeser¹, A. G. Thomas², A. A. Shaffer², J. Veale³, A. B. Massie², M. Cooper⁴, S. Kapur⁵, S. Kapur⁵, S. Kapur⁵, N. Turgeon⁶, D. Segev², A. Waterman³, S. Flechner⁷
¹East Carolina Univ Sch of Med, Greenville, NC, ²Johns Hopkins, Baltimore, MD, ³UCLA, Los Angeles, CA, ⁴Georgetown, Washington, DC, ⁵Weill Cornell Medical School, New York, NY, ⁶Emory, Atlanta, GA, ⁷Cleveland Clinic, Cleveland, OH
*Purpose: In the United States (US), kidney paired donation (KPD) networks have facilitated an increasing proportion of KTs annually, but longer-term transplant outcomes and differences…
2019 American Transplant Congress
Care of International Living Kidney Donor Candidates in the U.S.: A Survey of Contemporary Experience, Practice & Challenges
K. Lentine¹, M. Henderson², S. Rasmussen², E. Shukhman³, J. Hunt⁴, F. Al Ammary², V. Kumar⁵, D. Lapointe-Rudow⁴, H. Schaefer⁶, M. Cooper⁷, R. Hays⁸, M. Dunbar-Forrest⁹, A. Nishio-Lucar¹⁰, D. Mandelbrot⁸
¹Saint Louis Univ, Saint Louis, MO, ²Johns Hopkins, Baltimore, MD, ³Cedars Sinai, Los Angeles, CA, ⁴Mount Sinai, New York, NY, ⁵Univ Alabama, Birmingham, AL, ⁶Vanderbilt, Nashville, TN, ⁷Georgetown, Washington, DC, ⁸Univ Wisconsin, Madison, WI, ⁹UCLA, Los Angeles, CA, ¹⁰Univ Virginia, Charlottesville, VA
*Purpose: The evaluation and care of non-U.S. citizen, non-U.S. residents who wish to come to the U.S. to serve as living kidney donors (LKD) can…
2019 American Transplant Congress
Organ Resilience Contributes to Different Impact of Delayed Graft Function (DGF) on Graft Survival in Kidneys Donated by Brain Death (DBD) and Circulatory Death Donors (DCD)
M. J. de Kok, A. F. Schaapherder, L. G. Wijermars, D. K. de Vries, J. L. Lindeman
Transplantation Center, LUMC, Leiden, Netherlands
*Purpose: Despite a tripled higher incidence of DGF in DCD kidney grafts compared to DBD kidney grafts, large studies show equivalent long-term graft survival with…