Articles tagged "Kidney transplantation"

2019 American Transplant Congress
Single Cell Sequencing of Human Kidney Allograft
H. Yang¹, H. Suryawanshi², M. Lagman¹, M. Lubetzky¹, A. Alonso¹, S. Seshan¹, T. Tuschl², M. Suthanthiran¹, T. Muthukumar¹
¹Weill Cornell Medicine, New York, NY, ²Rockefeller University, New York, NY
*Purpose: Transcriptome-based clustering of individual cells within the kidney allograft may help identify cell type-specific injury and has the potential to redefine the current histopathology-based…
2019 American Transplant Congress
Early Steroid Withdrawal in African American Deceased Donor Renal Transplant Recipients with Alemtuzumab Induction: Is Graft Loss on the Horizon?
R. Lynn, B. Ravichandran, T. Sparkes, A. Haririan, J. Bromberg, J. Casale
University of Maryland Medical Center, Baltimore, MD
*Purpose: The safety of early steroid withdrawal (ESW) in African American (AA) deceased donor renal transplant recipients (DDRTs) is unclear. This study assessed the impact…
2019 American Transplant Congress
External Validation of the Living Kidney Donor Profile Index (LKDPI) in the Canadian Kidney Transplant Recipient Population
M. Shantier¹, Y. Li¹, M. Ashwin¹, O. Famure¹, S. K. Singh²
¹Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada, ²Department of Medicine, University of Toronto, Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada
*Purpose: The LKDPI is a risk index which incorporates clinical characteristics of living kidney donors and their recipients to predict the risk of total graft…
2019 American Transplant Congress
Humoral Immune Responses to Kidney Associated Non-HLA Antigens is Not Associated with Progression to Chronic Immune Injury in Kidney Transplant Recipients
S. Sukumaran Nair¹, R. Ravichandran², R. Heilman¹, A. Jaramillo¹, D. Ramon¹, M. Buras¹, B. Kaplan¹, T. Mohanakumar²
¹Mayo Clinic, Phoenix, AZ, ²St. Joseph’s Hospital, Phoenix, AZ
*Purpose: Development of donor specific anti-HLA (DSA) although is a known risk factor for Chronic immune injury (CII), it is undetectable in many patients with…
2019 American Transplant Congress
The Effect of Kidney Transplantation on Neurocognitive Function: A Prospective Study
B. P. Concepcion, J. C. Jackson, A. Kiehl, R. Adu-Boahene, E. Collar, M. Reed, M. Sika, J. Van, R. C. Forbes
Vanderbilt University Medical Center, Nashville, TN
*Purpose: The effect of kidney transplantation on global cognition and executive function in patients with advanced kidney disease is unknown.*Methods: We prospectively enrolled patients scheduled…
2019 American Transplant Congress
Effectiveness Of Percutaneous Embolization As Treatment Compared To Nephrectomy For Renal Graft Intolerance Syndrome In Late Graft Failure Patients
S. Kwon, J. Go, S. Park, S. Yoon, J. Kim, I. Moon
Department of Vascular and Transplant Surgery, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea, Republic of
*Purpose: Failed renal allografts left in situ may cause inflammation presenting as graft intolerance syndrome (GIS). But there is no standardization for treatment of a…
2019 American Transplant Congress
Lower Extremity Impairment and Frailty among Adults with Diabetes Awaiting Kidney Transplantation
E. Lorenz, A. Kukla, C. Kennedy, R. McCoy, L. Hickson
Mayo Clinic, Rochester, MN
*Purpose: Frailty and lower extremity impairment, both indicators of poor physical performance, are predictive of all-cause mortality among patients awaiting kidney transplantation (KT). Diabetes, the…
2019 American Transplant Congress
High Fibre Diet Prevents Transplant-Associated Dysbiosis and Prevents Kidney Allograft Rejection
J. J. Singer¹, H. Wu¹, T. Kwan¹, Y. Loh¹, C. Wang¹, J. Tan², L. Macia², S. Alexander³, S. Chadban¹
¹Kidney Node Laboratory, Charles Perkins Centre, The University of Sydney, Sydney, Australia, ²Nutritional Immunometabolism Lab, Charles Perkins Centre, The University of Sydney, Sydney, Australia, ³The Children's Hospital Westmead, Sydney, Australia
*Purpose: To investigate the impact of high fibre (HF) diet or dietary supplementation with the short chain fatty acid (SCFA) sodium acetate (SA) on kidney…
2019 American Transplant Congress
IL-6R Blockade with Tocilizumab Increases Tregs and Decreases Early Graft Inflammation in Kidney Transplant Recipients: Results of a Randomized Controlled Trial
S. Chandran, J. Leung, Z. Laszik, Q. Tang, C. Hu, M. Joanes, F. Vincenti
UCSF, San Francisco, CA
*Purpose: IL-6, a proinflammatory cytokine and key regulator of Treg/Th17 balance, is strongly associated with renal graft rejection. We hypothesized that IL-6 blockade with tocilizumab…
2019 American Transplant Congress
SIRPα Typing as a Potential Tool for Risk Stratification in Kidney Transplantation
A. Casillas-Abundis, A. Tambur, D. F. Pinelli, R. Hod-Dvorai, C. Garcia-Sanchez
Transplant Immunology Laboratory, Northwestern University, Chicago, IL
*Purpose: To determine if mismatches in the SIRPα receptor, associated with initiate innate alloresponses in animal models, may impact human kidney transplantation outcome.*Methods: To avoid…