Articles tagged "Kidney transplantation"

2020 American Transplant Congress
Uromodulin to Osteopontin Ratio in Deceased Donor Urine is Associated with Kidney Graft Outcomes
S. G. Mansour¹, C. Liu², Y. Jia², P. Reese³, I. Hall⁴, T. El-Achkar⁵, K. LaFavers⁵, W. Obeid², M. Thangamani⁶, A. Rosenberg², M. Doshi⁷, E. Akalin⁸, J. Bromberg⁹, M. Harhay¹⁰, S. Mohan¹¹, B. Schröppel¹², P. Daneshpajouhnejad², P. Singh¹³, F. Weng¹⁴, H. Thiessen-Philbrook², C. Parikh²
¹Yale, New Haven, CT, ²Johns Hopkins, Baltimore, MD, ³UPenn, Philadelphia, PA, ⁴Univ of Utah, Salt Lake City, UT, ⁵Indiana Univ, Bloomington, IN, ⁶Cornell, New York, NY, ⁷Univ of Michigan, Ann Arbor, MI, ⁸Montefiore, Bronx, NY, ⁹Univ of Maryland, College Park, MD, ¹⁰Drexel, Philadelphia, PA, ¹¹Columbia, NY, NY, ¹²Univ Hosp, Ulm, Germany, ¹³Thomas Jefferson, Philadelphia, PA, ¹⁴St. Barnabas, Livingston, NJ
*Purpose: Deceased-donor kidneys often experience extensive injury, activating adaptive and maladaptive pathways. While these adaptive and maladaptive mechanisms are initiated in donor kidneys prior to…
2020 American Transplant Congress
Your Path to Transplant Tailored Education Increases Living Donation Transplant Actions and Wait-Listing Rates: Final Randomized Controlled Trial Findings
A. Waterman¹, Y. Cui², J. L. Beaumont², J. D. Peipert³, A. Paiva⁴, M. L. Robbins⁴
¹Transplant Research and Education Center, Los Angeles, CA, ²Terasaki Research Institute, Los Angeles, CA, ³Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁴Department of Psychology, University of Rhode Island, Kingston, RI
*Purpose: Tailoring education and behavior change interventions to address gaps in individual patients’ knowledge, readiness, and socio-economic challenges may help more end-stage kidney disease patients…
2020 American Transplant Congress
Multi-Center, Open-Label Trial of Pre-Emptive Glecaprevir/Pibrentasvir (G/P) to Treat Recipients of Transplanted Kidneys from Deceased Donors with Hepatitis C Virus (MYTHIC)
M. Sise¹, D. Goldberg², J. Kort³, D. Schaubel⁴, R. Alloway⁵, C. Durand⁶, R. Fontana⁷, J. Friedewald⁸, R. Brown⁹, S. Prenner¹⁰, R. Landis⁴, P. Reese¹¹, R. Chung¹
¹Internal Medicine - Nephrology, MGH, Boston, MA, ²Hepatology and Transplantation, U Miami, Miami, FL, ³Abbvie, Chicago, IL, ⁴Department of Biostatistics, U Penn, Philadelphia, PA, ⁵Department of Internal Medicine - Nephrology and Hypertension, U Cincinnati, Cincinnati, OH, ⁶Department of Medicine, JHU, Baltimore, MD, ⁷Internal Medicine - Gastroenterology, U Michigan, Ann Arbor, MI, ⁸Internal Medicine - Nephrology and Hypertension, Northwestern, Chicago, IL, ⁹Internal Medicine - Hepatology, Weill Cornell, NYC, NY, ¹⁰Internal Medicine - Gastroenterology, U Penn, Philadelphia, PA, ¹¹Transplant Nephrology, U Penn, Philadelphia, PA
*Purpose: Kidneys from Hepatitis C virus (HCV)-infected deceased donors continue to be discarded at high rates despite small, successful studies of HCV-viremic donors into uninfected…
2020 American Transplant Congress
Feasibility and Long Term Safety of T Regulatory Cell Therapy in Kidney Transplantation
P. N. Harden¹, D. Game², J. Van der Net¹, F. Issa³, W. Petchey¹, M. Brook¹, P. Friend¹, R. Hilton⁴, G. Lombardi⁵, K. Wood³
¹Kidney Transplantation, Oxford University Hospitals NHS Trust, Oxford, United Kingdom, ²Kidney Transplantation, Guys and St Thomas's Hospital, London, United Kingdom, ³Transplant Immunology Research Group, Oxford University, Oxford, United Kingdom, ⁴Kidney Transplantation, Guys and St Thomas's Hospital, Oxford, United Kingdom, ⁵Transplant Immunology Group, Kings Healthcare Partners, London, United Kingdom
*Purpose: A sequential clinical trial of autologous polyclonal T regulatory cellular therapy compared with a standardised reference cohort of live donor kidney transplant recipients. The…
2020 American Transplant Congress
The Impact Of Weight Reduction Surgery And Morbid Obesity On Renal Function After Transplantation
S. Negi¹, N. Saberi¹, P. Bouchard², a. Andalib², M. Cantarovich¹, S. Paraskevas¹, J. Tchervenkov¹
¹RIMUHC, Montreal, QC, Canada, ²McGill University, Montreal, QC, Canada
*Purpose: Morbid obesity is a significant barrier and renal transplantation is rarely offered to patients with Class III obesity (body mass index (BMI) > 40…
2020 American Transplant Congress
Benefits of Transplantation Over Chronic Dialysis in Septugenerian ESRD Patients with Diabetes
S. Karhadkar, A. Shaik, A. Di Carlo
Temple University School of Medicine, Philadelphia, PA
*Purpose: In 2016, nearly 125,000 adults in the United States began treatment for end-stage renal disease (ESRD) (i.e., kidney failure requiring dialysis or transplantation). Of…
2020 American Transplant Congress
Viral Integration In BK Polyomavirus-Associated Urothelial Carcinoma in Renal-Transplant Recipients: Multistage Carcinogenesis Revealed by Next Generation Virome Capture Sequencing
Y. Wang¹, Y. Liu¹, W. Deng¹, F. Fu¹, S. Yan¹, H. Yang¹, M. Luo², R. Liu¹, J. Geng¹, J. Xu¹, Y. Wu¹, J. Ma³, J. Zhou³, N. Liu³, Y. Jin¹, R. Xia¹, N. Elias⁴, R. J. Lee⁵, A. S. Feldman⁶, M. L. Blute⁶, R. B. Colvin⁷, C. Wu⁷, Y. Miao¹
¹Department of Organ Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou, China, ²State Key Laboratory of Virology, Wuhan Institute of Virology, Wuhan, China, ³Mygenostics Co., Beijing, China, ⁴Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁵Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁶Department of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁷Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
*Purpose: To elucidate the mechanism of carcinogenesis by BK Polyomavirus (BKV) integration in immunocompromised patients.*Methods: Virome capture sequencing and whole genome sequencing were performed on…
2020 American Transplant Congress
Outcomes of Successive Pregnancies in Kidney Transplant Recipients
S. Rao¹, L. Coscia², S. Constantinescu³, M. J. Moritz⁴
¹Medicine, University of Virginia Heath System, Charlottesville, VA, ²Transplant Pregnancy Registry International, Philadelphia, PA, ³Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, ⁴Surgery, Lehigh Valley Health Network, Allentown, PA
*Purpose: Pregnancy after transplant is considered high risk; nevertheless female kidney transplant (KT) recipients may have several post-transplant pregnancies. The aim of this study was…
2020 American Transplant Congress
Comparing Weight-Based Dosing of Envarsus XR in Obese and Non-Obese Renal Transplant Recipients
N. Breslin, N. Jandovitz, V. Nair, M. Abate, L. Teperman
North Shore University Hospital, Manhasset, NY
*Purpose: Tacrolimus has a narrow therapeutic window and significant inter- and intra-patient variability leading to variations in drug concentration. The recommended initial weight-based dose of…
2020 American Transplant Congress
Daratumumab for Desensitization and Antibody Mediated Rejection Treatment in Highly-HLA Sensitized Patients
S. Jordan, R. Vescio, N. Ammerman, M. Toyoda, S. Ge, M. Chu, J. Hou, E. Huang, A. Peng, S. Sethi, R. Najjar, K. Lim, J. Kobashigawa, J. Patel, E. Kransdorf, A. Vo
Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: Highly-HLA sensitized (HS) patients have an immunologic barrier to transplantation. ABMR promotes graft loss and poor patient survival. Methods to reduce anti-HLA antibodies are…