Articles tagged "Kidney transplantation"

2020 American Transplant Congress
The Risks Associated with Blood Transfusions in Kidney Transplant Recipients: A Retrospective Cohort Study Using Health Administrative Data
D. Massicotte-Azarniouch¹, M. Sood², D. Fergusson³, M. Chassé⁴, A. Tinmouth⁵, G. Knoll⁶
¹Medicine, University of Ottawa, Ottawa Hospital, Ottawa, ON, Canada, ²Medicine, University of Ottawa, Ottawa Hospital Research Insitute, Ottawa, ON, Canada, ³Clinical Epidemiology, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, ON, Canada, ⁴Medicine, University of Montreal, Montreal, QC, Canada, ⁵Hematology, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, ON, Canada, ⁶Medicine, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, ON, Canada
*Purpose: Red blood cell transfusion (RBCT) is a common occurrence in kidney transplant recipients, however it may carry certain risks which could be detrimental to…
2020 American Transplant Congress
Frailty at Time of Kidney Transplant Evaluation is Associated with Higher Rate of Waitlist Denial
J. Klein¹, A. Jurgensen², M. Gupta¹, N. Herrera¹, A. Gupta¹, D. Cibrik¹
¹Nephrology, University of Kansas Medical Center, Kansas City, KS, ²University of Kansas Medical Center, Kansas City, KS
*Purpose: To determine the association of patient frailty, as assessed by the Fried frailty score at the time of kidney transplant evaluation (KTE), with kidney…
2020 American Transplant Congress
Outcomes of Post-Transplant Desensitization in High Immunological Risk Deceased Donor Kidney Transplant Recipients
D. Kumar, C. Song, L. Kamal, I. Moinuddin, M. Levy, C. Bhati, A. King, P. Kimball, G. Gupta
Virginia Commonwealth University, Richmond, VA
*Purpose: The kidney allocation system (KAS) was changed in 2015 to increase access to transplants for highly sensitized patients. However, recent data suggests that even…
2020 American Transplant Congress
Osmotic Nephropathy from a Non-Sucrose Based IVIG
S. Reddy, L. Kodali
Nephrology, Mayo Clinic, Phoenix, AZ
*Purpose: We present a case of acute renal failure and hyperkalemia due to osmotic nephropathy from a non-sucrose based IVIG infusion therapy.*Methods: A 67-year-old man…
2020 American Transplant Congress
A Single Center Experience of Atypical Hemolytic Uremic Syndrome Post Solid Organ Transplantation – “Benign Genetic Variants: Perhaps No More”
M. Khan, M. Anand, T. Kaur, S. Bumb, S. Shah, A. Govil, B. G. Abu Jawdeh
University of Cincinnati, Cincinnati, OH
*Purpose: Atypical hemolytic uremic syndrome (aHUS) is a genetic-based thrombotic microangiopathy (TMA) that is mediated by the activation of the alternative complement pathway. Heterozygous deletion…
2020 American Transplant Congress
Renal Immunoproteasome Function: A Possible Cause for Macrophage Associated Organ Damage During Renal Transplantation?
N. Parajuli, A. Khakurel
University of Arkansas for Medical Sciences, Little Rock, AR
*Purpose: A major hurdle in the field of renal transplantation is the shortage of suitable donor kidneys. Renal transplantation using living-donor organs perform better when…
2020 American Transplant Congress
Anti-Thymocyte Globulins Induced Immunomodulatory Effect and Increased Regulatory T Cell in a In Vitro Model of Allogeneic Cell Coculture
M. Colladant¹, J. Lion², P. Saas³, S. Perruche³, D. Ducloux¹, N. Mooney², J. Bamoulid¹
¹Nephrologie, Dialyse et Transplantation, CHU de Besançon, Besancon, France, ²Equipe INSERM: Endothelium, Inflammation et Alloreactivity INSERM UMR-S 976, Paris, France, ³INSERM U1098 RIGHT, Université de Franche-Comté EFS Bourgogne Franche-Comté, Besancon, France
*Purpose: Two types of Anti-Thymocyte Globulins (ATG) are commonly used in renal transplantation (Thymoglobuline and Grafalon) and induce severe, dose-dependent and sometimes persistent CD4+ T…
2020 American Transplant Congress
Tissue Resident Memory T Cells in Mouse Renal Transplantation
K. Abou-Daya¹, D. Zhao¹, R. Tieu¹, R. Rammal², M. Oberbarnscheidt¹, F. Lakkis¹
¹Starzl Transplantation Institute, Pittsburgh, PA, ²American University of Beirut, Beirut, Lebanon
*Purpose: The newly identified tissue resident subset of memory T cells (TRM) provides immune surveillance in the tissue and first response against infections. They are…
2020 American Transplant Congress
Deceased Donors in Kidney Paired Donation
J. D. Kalbfleisch¹, W. Wang¹, M. A. Rees², A. B. Leichtman³, P. X. Song¹, V. Ashby¹, T. Shearon¹
¹Biostatistics, University of Michigan, Ann Arbor, MI, ²University of Toledo, Toledo, OH, ³University of Michigan, Ann Arbor, MI
*Purpose: A kidney paired donation pool (KPDP) consists of transplant candidates and their incompatible living donors along with nondirected living donors (NDDs). In a match…
2020 American Transplant Congress
Prospective, Randomized Study of Conversion from Calcineurin Inhibitor (CNI)- to Belatacept (BELA)-Based Maintenance Immunosuppression in Renal Transplant Recipients
K. Budde¹, R. Prashar², H. Haller³, M. Rial⁴, N. Kamar⁵, A. Agarwal⁶, J. de Fijter⁷, L. Rostaing⁸, S. Berger⁹, A. Djamali¹⁰, N. Leca¹¹, L. Allamassey¹², S. Gao¹², M. Polinsky¹², F. Vincenti¹³
¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²Henry Ford Hospital, Detroit, MI, ³The Hannover Medical School, Hannover, Germany, ⁴Instituto de Nefrologia, Nephrology SA, Buenos Aires, Argentina, ⁵University of Toulouse, Toulouse, France, ⁶UVA Health, Charlottesville, VA, ⁷Leiden University Medical Center, Leiden, Netherlands, ⁸Université Grenoble Alpes, Saint-Martin-d'Hères, France, ⁹University Medical Centre Groningen, Groningen, Netherlands, ¹⁰University of Wisconsin, Madison, WI, ¹¹UW Medical Center, Seattle, WA, ¹²Bristol-Myers Squibb, Princeton, NJ, ¹³University of California, San Francisco, San Francisco, CA
*Purpose: CNIs are associated with adverse systemic and nephrotoxic effects that negatively impact long-term patient and graft survival. In a phase 2 study, switching renal…