Articles tagged "Kidney transplantation"

2020 American Transplant Congress
Peak DSA Levels Pre-Transplant but Not at Transplant Predict Graft Survival
A. Y. Choi¹, D. Olaso¹, T. Risoli Jr², M. Kuchibhatla², Z. Fitch³, R. Schmitz³, P. M. Schroder³, A. Jackson³, M. Manook³, J. Yoon³, A. B. Farris⁴, J. Kwun³, S. J. Knechtle³
¹Duke University School of Medicine, Durham, NC, ²Duke Biostatistics, Epidemiology, and Research Design Core, Duke University, Durham, NC, ³Department of Surgery, Duke University Medical Center, Durham, NC, ⁴Department of Pathology, Emory University Hospital, Atlanta, GA
*Purpose: Immunization to major histocompatibility complex (MHC) antigens is a barrier in kidney transplantation (KTx) due to higher risk of antibody-mediated rejection (AMR) and graft…
2020 American Transplant Congress
Low-Dose Rabbit Antithymocyte Globulin Induction in Elderly Kidney Transplant Recipients at High Immunologic Risk is Safe and May Prevent Excess Rejection
E. Sartain¹, B. Nettles¹, B. Crowther¹, P. Klem¹, K. Schwarz¹, S. Davis²
¹University of Colorado Hospital, Aurora, CO, ²University of Colorado School of Medicine, Aurora, CO
*Purpose: Patients aged ≥65 years are a growing segment of kidney transplant recipients (KTRs). Consensus on induction immunosuppression in this population is unclear given higher…
2020 American Transplant Congress
Kidney Paired Donation in Brazil
J. Bastos¹, M. Mankowski², S. Gentry³, A. Massie⁴, C. Bisi¹, C. Duarte¹, V. Colares¹, D. Segev⁴, G. Ferreira¹
¹Transplant, Santa Casa de Misericordia de Juiz de Fora, Juiz de Fora, Brazil, ²King Abdullah University of Science and Technology, Thuwal, Saudi Arabia, ³US Naval Academy, Annapolis, MD, ⁴JHU, Baltimore, MD
*Purpose: It is estimated that up to 30% of potential living donor/recipient pairs are unable to proceed to living donor kidney transplantation (LDKT) for immunological…
2020 American Transplant Congress
Would You Rather Receive a High KDPI SCD Kidney or a Lower KDPI ECD Kidney?
V. Gurram, D. Harriman, A. Farney, J. Rogers, G. Orlando, A. Reeves-Daniel, A. Mena-Gutierrez, C. Jay, R. Stratta
Abdominal Transplant Surgery, Wake Forest Baptist Health, Winston Salem, NC
*Purpose: The study purpose was to review our kidney transplant (KT) experience with emphasis placed on outcomes in patients receiving kidneys that were “discordant” within…
2020 American Transplant Congress
Understanding the Decision-Making of 2576 Potential Living Kidney Donors of Different Racial/Ethnic Backgrounds
A. Waterman¹, G. H. Kim¹, Y. Cui², O. N. Ranasinghe¹, J. L. Beaumont², D. Adey³, U. Reddy⁴, B. Campbell⁵, F. L. Weng⁶
¹Division of Nephrology, David Geffen School of Medicine, Los Angeles, CA, ²Terasaki Research Institute, Los Angeles, CA, ³UCSF Health, San Francisco, CA, ⁴UC Irvine, Irvine, CA, ⁵Cedars Sinai Medical Center, Los Angeles, CA, ⁶St. Barnabas Medical Center, Livingston, NJ
*Purpose: To better understand racial/ethnic disparities associated with kidney living donation, this study examined differences in potential living kidney donors’ decision-making, resistance to donation, and…
2020 American Transplant Congress
Systemic Venous versus Portal Venous Drainage in Simultaneous Pancreas-Kidney Transplantation: A Matched-Pair Analysis
V. Gurram, K. Gurung, A. Farney, J. Rogers, G. Orlando, C. Jay, A. Reeves-Daniel, R. Stratta
Abdominal Transplant Surgery, Wake Forest Baptist Health, Winston Salem, NC
*Purpose: The study purpose was to evaluate outcomes in vascularized pancreas transplantation (PTx) with enteric exocrine drainage based on technique of venous delivery.*Methods: We retrospectively…
2020 American Transplant Congress
Kidney Transplant Recipients with De Novo Donor Specific Antibody is Associated with Increased Risk of Developing BK Viremia
S. Kareem¹, L. Suresh², A. Gundroo¹, J. Von Viger¹, S. Chang¹
¹Internal Medicine, University of Buffalo, Buffalo, NY, ²Pathology, University of Buffalo, Buffalo, NY
*Purpose: Background: De novo donor specific anti-HLA antibodies (dnDSA) has profound effect on the renal graft long-term function and survival. Studies has shown identifications of…
2020 American Transplant Congress
HLA Mismatch Immunogenicity: Are We Predicating Mismatches That Induce De Novo DSA Development or That Do Not?
V. Jucaud¹, L. Rebellato², K. Briley², C. Haisch², S. Kendrick³, H. Jones³, K. Mclawhorn³, D. Leeser², M. Everly¹
¹Terasaki Research Institute, Los Angeles, CA, ²East Carolina University, Greenville, NC, ³Eastern Nephrology Associates, Greenville, NC
*Purpose: Although the development of de novo donor-specific anti-HLA antibodies (dnDSA) remains a major risk factor for poor long-term kidney allograft outcomes, the prediction of…
2020 American Transplant Congress
Single Center Experience in Using Donor-Derived Cell-Free DNA in Kidney Transplant
P. Homkrailas¹, S. Lee², B. Kandagedon¹, G. Danovitch¹, S. Bunnapradist¹
¹Medicine, Division of Nephrology, Kidney and Pancreas Transplant Programs, UCLA, Los Angeles, CA, ²Department of Pharmacy, UCLA, Los Angeles, CA
*Purpose: While the gold standard for diagnosing allograft rejection in kidney transplant recipients (KTX) continues to be histopathologic evaluation, it has been well recognized that…
2020 American Transplant Congress
Mitochondrial Metabolism is Enriched Following Normothermic Ex-Vivo Kidney Perfusion of Grafts Procured Following Cardiac Death
P. Urbanellis¹, C. McEvoy¹, L. Mazilescu¹, S. Ganesh¹, R. John¹, I. Mucsi¹, A. Ghanekar¹, D. Bagli², A. Konvalinka¹, L. Robinson², M. Selzner¹
¹University Health Network, Toronto, ON, Canada, ²The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: Normothermic ex-vivo kidney perfusion (NEVKP) preservation has demonstrated superior graft outcomes for kidneys procured following donation-after-cardiac death (DCD) over static cold storage (SCS). To…