Articles tagged "Kidney transplantation"

2020 American Transplant Congress
Clinical Outcomes Associated with Long-Term Exposure to Airborne Particulate Pollution in Kidney Transplant Recipients
Y. Kim¹, J. Lee²
¹Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ²Internal Medicine, Seoul National University Boramae Hospital, Seoul, Korea, Republic of
*Purpose: We aimed to evaluate the relationship of 10-μm particulate matter (PM10) with the risk of graft failure, mortality, and decline of graft function in…
2020 American Transplant Congress
Single Cell RNA Sequencing of Normal Kidney Allograft Surveillance Biopsies Show Evidence of Dynamic Glomerular Endothelial Cell Activation
A. S. Naik, R. Menon, E. Otto, C. C. Berthier, E. Farkash, S. P. Norman, M. Kretzler
University of Michigan, Ann Arbor, MI
*Purpose: Indication and surveillance biopsy studies show a high prevalence of post kidney transplant (KT) glomerular disease (ElZoghby 2009,Stegall 2017) that cannot be explained by…
2020 American Transplant Congress
High Volume, Highly Efficient, Outcome- Centric KPD Program: A Single Center Experience with Direct Exchange Based Strategies
K. Al Meshari, D. Broering, I. Alahmadi, S. Raza, T. Ali, A. Alabbassi, H. Alahdal, F. Alzayer
King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia
*Purpose: We report our three and a half year experience with direct exchange (loop) based strategy single center KPD program.*Methods: 1. Inclusion of HLA and…
2020 American Transplant Congress
Belatacept-Based, Calcineurin Inhibitor and Corticosteroid Free Immunosuppression: Differential Outcomes Based on Recipient Age
N. Wilson¹, A. R. Shields², D. Kaufman³, A. Wiseman⁴, A. L. Christianson¹, S. Tremblay¹, J. P. Leone⁵, A. J. Matas⁶, P. West-Thielke⁷, R. R. Alloway¹, E. S. Woodle¹
¹U Cincinnati, Cincinnati, OH, ²The Christ Hospital, Cincinnati, OH, ³U Wisconsin, Madison, WI, ⁴U Colorado, Denver, CO, ⁵Tampa General, Tampa, FL, ⁶U Minnesota, Minneapolis, MN, ⁷U Illinois Chicago, Chicago, IL
*Purpose: Age-based disparities have been described in calcineurin inhibitor (CNI)-based immunosuppression regimens, but are not well-described for belatacept (BELA)-based regimens. This study analyzed the effect…
2020 American Transplant Congress
Mortality Index Should Be Used to Provide Realistic Expectations Regarding Transplant Candidacy
Y. Chalicheemala¹, K. Chavin², T. Srinivas¹, A. Padiyar¹
¹Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, ²Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH
*Purpose: Renal transplant improves outcomes of well-selected elderly patients with end stage renal disease. Older patients with significant comorbidities may not live long enough to…
2020 American Transplant Congress
TRANSBIO Study: Clinical Evaluation of Immunobiogram, a Novel In Vitro Diagnostic Immunoassay to Guide Adjustment of Immunosuppressive Therapy in Kidney Transplantation
J. Pascual¹, C. Jiménez², M. Krajewska³, C. Kotton⁴, D. Seron⁵, J. Portolés⁶, O. Witzke⁷, S. S. Sorensen⁸, A. Andrés⁹, T. Díez¹⁰, A. Ortega¹⁰, I. Portero¹⁰
¹Consorci Mar Parc de Salut, Barcelona, Spain, ²La Paz Hospital, Madrid, Spain, ³Wroclaw Medical University, Wroclaw, Poland, ⁴Massachusetts General Hospital, Boston, MA, ⁵Vall d’Hebron Hospital, Barcelona, Spain, ⁶Puerta de Hierro Mahadahonda Hospital, Madrid, Spain, ⁷University Hospital Essen, University Duisburg-Essen, Essen, Germany, ⁸Rigshospitalet, Copenhagen, Denmark, ⁹12 de Octubre Hospital, Madrid, Spain, ¹⁰Biohope Scientific Solutions for Human Health SL, Madrid, Spain
*Purpose: Immunobiogram (IMBG) is a first-in-class blood-based pharmacodynamic immunoassay that provides the sensitivity/resistance profile of each patient’s lymphocytes to a panel of immunosuppressive drugs (IS).…
2020 American Transplant Congress
Clinical Significance of T Cell and B Cell Epitope Prediction as a Risk Factor of De Novo DSA Production after Kidney Transplantation
T. Kobayashi¹, K. Iwasaki¹, T. Tomosugi², Y. Miwa¹, M. Niemann³, E. Spierings⁴, K. Horimi¹, Y. Matsuoka¹, A. Takeda², N. Goto², S. Narumi², Y. Watarai²
¹Aichi Medical University School of Medicine, Nagakute, Japan, ²Nagoya Daini Red Cross Hospital, Nagoya, Japan, ³PIRCHE AG, Berlin, Germany, ⁴UMC Utrecht, Utrecht, Netherlands
*Purpose: Chronic antibody-mediated rejection caused by de novo DSA (dnDSA) is a major cause of graft failure. Risk prediction of dnDSA would be important for…
2020 American Transplant Congress
Longer-Term Outcomes from the THINKER and EXPANDER Trials of Transplantation Using HCV-Viremic Kidneys
V. S. Potluri¹, F. Naqvi², P. Reese¹, M. Shah¹, D. Brown², S. Prenner¹, A. Loupy³, A. Woodards¹, P. Abt¹, E. Blumberg¹, J. Trofe-Clark¹, D. Segev², R. Bloom¹, D. Sawinski¹, C. Durand², P. Porrett¹, M. Levine¹, D. Goldberg⁴, N. Desai²
¹University of Pennsylvania, Philadelphia, PA, ²Johns Hopkins, Baltimore, MD, ³Paris Transplant Group, Paris, France, ⁴University of Miami, Miami, FL
*Purpose: The practice of transplanting HCV-viremic kidneys into HCV-negative recipients has become more common, but longer-term outcomes have not been reported. We present data on…
2020 American Transplant Congress
Outcomes Associated with Mycophenolate Weight-Based Dosing in Varying Immunologic Risk Kidney Transplant Recipients
A. A. Al-Bahou, A. R. Webb, M. Bloxam, L. J. Bowman Anger, R. S. Baliga, A. J. Brueckner
Tampa General Hospital, Tampa, FL
*Purpose: Mycophenolate acid (MPA) is traditionally dosed in kidney transplant recipients (KTR) using the FDA-approved fixed dosing which is irrespective of patient-specific variables such as…
2020 American Transplant Congress
Continuous Improvement in Long Term Survival of Kidney Transplants Over the Past Two Decades
E. D. Poggio¹, S. Arrigain², A. Wee³, D. C. Brennan⁴, J. D. Schold²
¹Nephrology, Cleveland Clinic, Cleveland, OH, ²Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, ³Urology, Cleveland Clinic, Cleveland, OH, ⁴Nephrology, Johns Hopkins, Baltimore, MD
*Purpose: Short-term kidney transplant (KTx) graft survival has improved during past decades, but prior research has indicated stagnation or minimally improving long-term outcomes. We studied…