Articles tagged "Kidney transplantation"

2020 American Transplant Congress
Establishing an Induction Protocol for Long-Term Multilineage Mixed Chimerism in Rhesus Macaques
K. Bruestle¹, H. Sakai¹, F. Fredriksson¹, B. Piegari¹, D. Ekanayake-Alper¹, A. McLuckie², R. Ober², J. Weiner¹, A. Iuga³, S. M. Coley³, M. Sykes¹, A. Griesemer¹
¹Columbia Center for Translational Immunology, Columbia University, New York City, NY, ²Institute for Comparative Medicine, Columbia University, New York City, NY, ³Department of Pathology and Cell Biology, Columbia University, New York City, NY
*Purpose: Mixed chimerism (MC) induction via non-myeloablative conditioning and bone marrow transplantation (BMT) induces tolerance to solid organs. Our standard MC induction protocol in cynomologous…
2020 American Transplant Congress
Geographic Variation in Listing for Kidney Transplantation: A State-Level Assessment of Access among Patients with End-Stage Renal Disease in the United States
M. N. Mustian, H. Qu, D. Anderson, P. A. MacLennan, R. D. Reed, C. Kale, B. Orandi, B. A. Shelton, V. Kumar, M. Hanaway, J. E. Locke
University of Alabama at Birmingham, Birmingham, AL
*Purpose: Barriers to deceased donor kidney transplantation (DDKT) exist, including referral for transplant and waitlist addition, which may vary regionally. The objective of this study…
2020 American Transplant Congress
Determinants of Cardiovascular Benefit Observed in a Population with a Functioning Renal Transplant versus Patients Undergoing Chronic Dialysis
J. Sleiman, C. Castellaro, G. Laham, M. Schiavone, M. Biain, L. Brukman, G. Soler Pujol, C. Diaz
Nephrology, CEMIC, Caba, Argentina
*Purpose: Patients (pts) with end stage renal disease have a high morbidity and mortality rate, mostly due to cardiovascular events (CV). Transplantation (Tx) improves survival…
2020 American Transplant Congress
Early Impact of Interleukin-6 Blockade on the Distribution of Peripheral Blood Immune Cell Subpopulations – 3-Month Results of a Phase 2 Trial Evaluating Clazakizumab in Late Antibody-Mediated Rejection
K. A. Doberer¹, G. A. Boehmig¹, M. Streitz², S. Schlickeiser², F. Bauernfeind¹, A. Spittler³, B. Jilma⁴, F. Eskandary¹, E. Chong⁵, S. Schranz⁴, K. Budde⁶, M. Dürr⁶
¹Department of Medicine III, Medical University of Vienna, Vienna, Austria, ²Charité Universitätsmedizin Berlin, Institute of Medical Immunology, Berlin, Germany, ³Center of Translational Research, Medical University of Vienna, Vienna, Austria, ⁴Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria, ⁵Vitaeris Inc., Vancouver, BC, Canada, ⁶Division of Nephrology and Intensive Care, Charité Universitätsmedizin Berlin, Berlin, Germany
*Purpose: Interleukin-6 (IL-6) is considered to play a critical role within the multifacted pathophysiological process of antibody-mediated rejection (ABMR), including modulation of regulatory T cells…
2020 American Transplant Congress
The Evolution of Renal Graft Failure Risk: The Power of the Proximal
T. Mayne¹, S. Mohan²
¹Angion Biomedica, San Francisco, CA, ²Columbia University Medical Center, New York, NY
*Purpose: Our goal was to examine the association of eGFR in the first year on long term outcomes following kidney transplant.*Methods: The sample included kidney…
2020 American Transplant Congress
Evaluation of Leukopenia and Neutropenia Incidence, Treatment, and Clinical Response in Kidney and Liver Transplant Recipients
H. Kutzler, T. Webb, R. Cecere, D. O'Sullivan, P. Sheiner
Hartford Hospital, Hartford, CT
*Purpose: The purpose is to evaluate incidence, recurrence, therapy modifications, and complications of leukopenia and neutropenia (LN) in kidney (KTR) and liver transplant (LTR) recipients.*Methods:…
2020 American Transplant Congress
Real-World Experiences in the Transplantation of Hepatitis C Positive Kidneys
J. M. Steinbrink, J. Byrns, L. Crona, M. Ellis, S. Sanoff, E. K. Maziarz, C. R. Wolfe
Duke University, Durham, NC
*Purpose: With advancements of direct-acting antivirals, transplantation of HCV-NAT+ (HCV+) organs to HCV-negative (HCV-) recipients has been used to decrease wait times without apparent sacrifice…
2020 American Transplant Congress
Barriers for Kidney Transplant Evaluation among People Living with HIV and End-Stage Renal Disease in Mississippi
L. A. Shimose¹, M. X. Bueno Rios¹, J. Clark¹, A. Torres², D. Garcia-Anton², W. Cheungpasitporn², P. Vaitla², F. Cabeza-Rivera²
¹Infectious Diseases, University of Mississippi Medical Center, Jackson, MS, ²Nephrology, University of Mississippi Medical Center, Jackson, MS
*Purpose: The number of Kidney transplants (KTx) among people living with HIV (PLWH) who develop end-stage renal disease (ESRD) has been increasing in many transplant…
2020 American Transplant Congress
The Use of dd-cfDNA as a Predictive Tool for Future Proteinuria
S. Jordan¹, P. Sood², J. Bromberg³, D. Brennan⁴
¹Cedars-Sinai, Los Angeles, CA, ²University of Pittsburgh Medical Center, Pittsburgh, PA, ³University of Maryland, Baltimore, MD, ⁴The Johns Hopkins Hospital, Baltimore, MD
*Purpose: Most allografts with proteinuria >1500 mg/dL have new glomerular pathology. In contrast, lower levels of proteinuria are generally associated with non-glomerular, nonspecific histologic changes.…
2020 American Transplant Congress
5-Year Simulated Allocation of Deceased Donor Kidneys in 3 Contiguous States within Region 3 Under the Latest 250 nm Circle Distribution Proposal
C. Warren¹, N. Battula¹, A. Zarrinpar¹, T. Kozlowski¹, M. Johnson¹, K. Andreoni²
¹University of Florida, Gainesville, FL, ²Abdominal Transplant, Surgery, University of Florida, Gainesville, FL
*Purpose: The proposed kidney allocation replaces current local and regional by a 250 nautical mile (nm) radius circle from the actual donor hospital (DH) to…