Articles tagged "Kidney transplantation"

2020 American Transplant Congress
Experience with a BKV-Specific, Neutralizing Monoclonal Antibody (MAU868) for Treatment of Severe BK Virus Nephropathy (BKVN) after Kidney Transplant (FDA EIND #139112)
S. C. Jordan¹, S. J. Kovacs², J. R. Abend³, N. Ammerman¹, M. Toyoda¹, C. C. Nast¹, E. Huang¹, R. Najjar¹, S. Sethi¹, A. Peng¹, K. Lim¹, M. R. Hodges⁴, A. Vo¹
¹Cedars Sinai Medical Ctr, Los Angeles, CA, ²Novartis Institutes for BioMedical Research, East Hanover, NJ, ³Novartis Institutes for BioMedical Research, Emeryville, CA, ⁴Amplyx Pharmaceuticals, San Diego, CA
*Purpose: BK viral reactivation leading to nephropathy and allograft loss in kidney transplant recipients remains a significant challenge. No effective BKV-therapies are currently available. Management…
2020 American Transplant Congress
Pre-Transplant Pharmacogenetics Identifies CYP3A4 and CYP3A5 Heterogeneity among Caucasian Kidney Transplant Recipients
N. Oliver¹, L. Lindberg¹, S. LeCorchick¹, D. Morris¹, S. Anand¹, T. Srinivas²
¹Intermountain Medical Center, Murray, UT, ²University Hospitals Cleveland Medical Center, Cleveland, OH
*Purpose: Tacrolimus has always been dosed based on therapeutic drug monitoring, however pharmacogenomics is becoming increasingly more utilized in the era of precision based medicine…
2020 American Transplant Congress
Femto Pulse Analysis of Exosome RNA from Plasma of Renal Transplant Patients Confirmed the Unique Benefits of Plasma Exosome for Messenger RNA (mRNA) Transcript Analysis
H. Zhang¹, K. Wong², S. C. Jordan³, D. Warzak², M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, ²Agilent Technologies, Inc., Ankeny, IA, ³Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Previously, we reported the feasibility of measuring the mRNA transcript levels of various genes in plasma exosomes of renal transplant patients for prediction of…
2020 American Transplant Congress
Diagnostic Method of Acute Kidney Rejection after Transplantation Using Metabolome Analysis via a Liquid Biopsy Approach
H. Iwamoto
Department of Kidney Transplantation Surgery, Tokyo Medical University, Hachioji Medical Center, Tokyo, Japan
*Purpose: At present, a definitive diagnosis of organ dysfunction after transplantation (such as acute rejection) is dependent on conventional histopathological evaluation using an invasive biopsy…
2020 American Transplant Congress
A Multicenter, Randomized, Controlled Trial to Steer Immunosuppressive Therapy by Virus-Specific T Cells after Pediatric Kidney Transplantation (IVIST-Trial)
T. Ahlenstiel-Grunow¹, A. Großhennig¹, R. Schild², J. Oh², C. Taylan³, L. Weber³, H. Staude⁴, M. Verboom¹, C. Schröder¹, R. Sabau¹, A. Koch¹, X. Liu¹, L. Pape¹
¹Hannover Medical School, Hannover, Germany, ²University Hospital Hamburg-Eppendorf, Hamburg, Germany, ³University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany, ⁴University Hospital of Rostock, Rostock, Germany
*Purpose: Pharmakokinetic monitoring of immunosuppressants alone is insufficient to estimate the individual intensity of immunosuppression after kidney transplantation (Tx). Virus-specific T cells (Tvis) correlate with…
2020 American Transplant Congress
Kidney Paired Donation Outcomes among High PRA Recipients
A. Thomas¹, A. Shaffer², M. Henderson², D. Segev²
¹University of North Carolina, Chapel Hill, NC, ²Johns Hopkins, Baltimore, MD
*Purpose: Kidney paired donation (KPD) accounts for an increasing amount of living donor transplants in the US. Previous studies have shown equivalent outcomes between transplants…
2020 American Transplant Congress
Impact of Immunogenicity on Kidney Allograft Survival in Patients Treated with Induction Therapy
R. Michael, B. Mierzejewska, D. Bekbolsynov, J. Ortiz, O. Ekwenna, S. Stepkowski
University of Toledo, Toledo, OH
*Purpose: The induction therapy is currently used in the majority of kidney transplant recipients, regardless of their level of donor/recipient compatibility. We examined whether lower…
2020 American Transplant Congress
Discrepant Subtyping of Blood Type A2 Living Kidney Donors in Paired Kidney Exchange
L. Warnke¹, R. R. Redfield¹, K. M. Miller¹, M. Cooper², G. Roll³, C. Freise³, B. Lee³, V. Chipman³, A. Thomas⁴, D. Leeser⁵, M. Ronin⁶, G. Hil⁶, A. D. Waterman⁷, D. Mandelbrot¹
¹Transplant, UW Health, Madison, WI, ²Transplant, Medstar Georgetown, Washington, DC, ³Transplant, UCSF, San Fransisco, CA, ⁴Surgery, Johns Hopkins University, Baltimore, MD, ⁵Transplant, ECU, Greenville, NC, ⁶NKR, Babylon, NY, ⁷Nephrology, UCLA; Terasaki Research Institute, Los Angeles, CA
*Purpose: Utilizing non-A1 donors for O or B recipients with low anti-A titers presents an opportunity to expand living donor kidney transplantation. Since February 2018,…
2020 American Transplant Congress
Kidneys from AKI Donors with Poor Long-Term Outcomes Present an Impaired Protein Expression for Cellular Stress and Repair
F. Neri¹, M. Lo Faro¹, C. Boffa¹, T. Surik¹, M. Kaisar¹, E. J. Sharples², J. P. Hunter¹, J. Lindeman³, R. Ploeg¹
¹Nuffield Department of Surgical Sciences, Oxford University, Oxford, United Kingdom, ²Oxford Transplant Centre, Oxford, United Kingdom, ³Department of Vascular Surgery, Leiden University Medical Center (LUMC), Leiden, Netherlands
*Purpose: The utilization of kidneys from donors with acute kidney injury (AKI) is often limited by unpredictable post-transplantation outcomes. The aim of our study was…
2020 American Transplant Congress
Proposed New Kidney Allocation Policy: Moving to Concentric Circles as the First Unit of Allocation
A. Israni¹, S. Gustafson¹, A. Wey¹, B. Thompson¹, V. Casingal², M. Pavlakis³, S. Castro⁴, A. Wilk⁴, B. Kasiske¹, J. Snyder¹
¹SRTR, Minneapolis, MN, ²Carolinas Healthcare, Charlotte, NC, ³Beth Israel Deaconess, Boston, MA, ⁴UNOS, Richmond, VA
*Purpose: The Organ Procurement and Transplantation Network (OPTN) proposed a new national deceased donor kidney allocation policy that removes donor service area and OPTN region…