Articles tagged "Kidney transplantation"

2020 American Transplant Congress
Feasibility and Long Term Safety of T Regulatory Cell Therapy in Kidney Transplantation
P. N. Harden¹, D. Game², J. Van der Net¹, F. Issa³, W. Petchey¹, M. Brook¹, P. Friend¹, R. Hilton⁴, G. Lombardi⁵, K. Wood³
¹Kidney Transplantation, Oxford University Hospitals NHS Trust, Oxford, United Kingdom, ²Kidney Transplantation, Guys and St Thomas's Hospital, London, United Kingdom, ³Transplant Immunology Research Group, Oxford University, Oxford, United Kingdom, ⁴Kidney Transplantation, Guys and St Thomas's Hospital, Oxford, United Kingdom, ⁵Transplant Immunology Group, Kings Healthcare Partners, London, United Kingdom
*Purpose: A sequential clinical trial of autologous polyclonal T regulatory cellular therapy compared with a standardised reference cohort of live donor kidney transplant recipients. The…
2020 American Transplant Congress
The Impact Of Weight Reduction Surgery And Morbid Obesity On Renal Function After Transplantation
S. Negi¹, N. Saberi¹, P. Bouchard², a. Andalib², M. Cantarovich¹, S. Paraskevas¹, J. Tchervenkov¹
¹RIMUHC, Montreal, QC, Canada, ²McGill University, Montreal, QC, Canada
*Purpose: Morbid obesity is a significant barrier and renal transplantation is rarely offered to patients with Class III obesity (body mass index (BMI) > 40…
2020 American Transplant Congress
Benefits of Transplantation Over Chronic Dialysis in Septugenerian ESRD Patients with Diabetes
S. Karhadkar, A. Shaik, A. Di Carlo
Temple University School of Medicine, Philadelphia, PA
*Purpose: In 2016, nearly 125,000 adults in the United States began treatment for end-stage renal disease (ESRD) (i.e., kidney failure requiring dialysis or transplantation). Of…
2020 American Transplant Congress
Viral Integration In BK Polyomavirus-Associated Urothelial Carcinoma in Renal-Transplant Recipients: Multistage Carcinogenesis Revealed by Next Generation Virome Capture Sequencing
Y. Wang¹, Y. Liu¹, W. Deng¹, F. Fu¹, S. Yan¹, H. Yang¹, M. Luo², R. Liu¹, J. Geng¹, J. Xu¹, Y. Wu¹, J. Ma³, J. Zhou³, N. Liu³, Y. Jin¹, R. Xia¹, N. Elias⁴, R. J. Lee⁵, A. S. Feldman⁶, M. L. Blute⁶, R. B. Colvin⁷, C. Wu⁷, Y. Miao¹
¹Department of Organ Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou, China, ²State Key Laboratory of Virology, Wuhan Institute of Virology, Wuhan, China, ³Mygenostics Co., Beijing, China, ⁴Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁵Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁶Department of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁷Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
*Purpose: To elucidate the mechanism of carcinogenesis by BK Polyomavirus (BKV) integration in immunocompromised patients.*Methods: Virome capture sequencing and whole genome sequencing were performed on…
2020 American Transplant Congress
Outcomes of Successive Pregnancies in Kidney Transplant Recipients
S. Rao¹, L. Coscia², S. Constantinescu³, M. J. Moritz⁴
¹Medicine, University of Virginia Heath System, Charlottesville, VA, ²Transplant Pregnancy Registry International, Philadelphia, PA, ³Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, ⁴Surgery, Lehigh Valley Health Network, Allentown, PA
*Purpose: Pregnancy after transplant is considered high risk; nevertheless female kidney transplant (KT) recipients may have several post-transplant pregnancies. The aim of this study was…
2020 American Transplant Congress
Comparing Weight-Based Dosing of Envarsus XR in Obese and Non-Obese Renal Transplant Recipients
N. Breslin, N. Jandovitz, V. Nair, M. Abate, L. Teperman
North Shore University Hospital, Manhasset, NY
*Purpose: Tacrolimus has a narrow therapeutic window and significant inter- and intra-patient variability leading to variations in drug concentration. The recommended initial weight-based dose of…
2020 American Transplant Congress
Daratumumab for Desensitization and Antibody Mediated Rejection Treatment in Highly-HLA Sensitized Patients
S. Jordan, R. Vescio, N. Ammerman, M. Toyoda, S. Ge, M. Chu, J. Hou, E. Huang, A. Peng, S. Sethi, R. Najjar, K. Lim, J. Kobashigawa, J. Patel, E. Kransdorf, A. Vo
Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: Highly-HLA sensitized (HS) patients have an immunologic barrier to transplantation. ABMR promotes graft loss and poor patient survival. Methods to reduce anti-HLA antibodies are…
2020 American Transplant Congress
The Experience of 1000 Cases of Hand Assisted Laparoscopic Donor Nephrectomy for Living Donor Kidney Transplantation
T. Hiramitsu¹, T. Tomosugi¹, K. Futamura¹, M. Okada¹, N. Goto¹, S. Narumi¹, K. Uchida², Y. Watarai¹
¹Nagoya Daini Red Cross Hospital, Nagoya Aichi, Japan, ²Masuko Memorial Hospital, Nagoya Aichi, Japan
*Purpose: Due to the increasing number of kidney transplant candidates, living donor kidney transplantation becomes more necessary. For living donor kidney transplantation, safe and efficient…
2020 American Transplant Congress
Evaluation of Clinical Outcomes in Patients Receiving Antithrombotic Therapy Prior to Kidney Transplantation
A. Diamond¹, C. Antonacci², K. Lau³, A. Di Carlo³, S. Karhadkar³
¹Pharmacy, Temple University Hospital, Philadelphia, PA, ²Temple University School of Medicine, Philadelphia, PA, ³Surgery, Temple University Hospital, Philadelphia, PA
*Purpose: Patients with end stage renal disease (ESRD) often have significant cardiovascular comorbidities. Utilization of therapeutic anticoagulation (AC) and/or antiplatelet (AP) therapy poses an increased…
2020 American Transplant Congress
Pharmacokinetic Evaluation of a De Novo Envarsus XR® (tacrolimus Extended Release) Dosing Strategy in Kidney Transplant Recipients
J. Schulte¹, C. Kane¹, K. Cunningham¹, C. D'Agostino¹, M. Kapugi¹, A. Novak¹, A. Shetty², J. Leventhal², J. Friedewald²
¹Department of Pharmacy, Northwestern Memorial Hospital, Chicago, IL, ²Division of Transplantation, Northwestern Memorial Hospital, Chicago, IL
*Purpose: Envarsus XR® is a once-daily tablet formulation of tacrolimus recently approved for the prophylaxis of organ rejection in de novo kidney transplant recipients (KTx).…