Articles tagged "Kidney transplantation"

2020 American Transplant Congress
Belatacept-Based, Calcineurin Inhibitor and Corticosteroid Free Immunosuppression: Differential Outcomes Based on Recipient Age
N. Wilson¹, A. R. Shields², D. Kaufman³, A. Wiseman⁴, A. L. Christianson¹, S. Tremblay¹, J. P. Leone⁵, A. J. Matas⁶, P. West-Thielke⁷, R. R. Alloway¹, E. S. Woodle¹
¹U Cincinnati, Cincinnati, OH, ²The Christ Hospital, Cincinnati, OH, ³U Wisconsin, Madison, WI, ⁴U Colorado, Denver, CO, ⁵Tampa General, Tampa, FL, ⁶U Minnesota, Minneapolis, MN, ⁷U Illinois Chicago, Chicago, IL
*Purpose: Age-based disparities have been described in calcineurin inhibitor (CNI)-based immunosuppression regimens, but are not well-described for belatacept (BELA)-based regimens. This study analyzed the effect…
2020 American Transplant Congress
Mortality Index Should Be Used to Provide Realistic Expectations Regarding Transplant Candidacy
Y. Chalicheemala¹, K. Chavin², T. Srinivas¹, A. Padiyar¹
¹Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, ²Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH
*Purpose: Renal transplant improves outcomes of well-selected elderly patients with end stage renal disease. Older patients with significant comorbidities may not live long enough to…
2020 American Transplant Congress
TRANSBIO Study: Clinical Evaluation of Immunobiogram, a Novel In Vitro Diagnostic Immunoassay to Guide Adjustment of Immunosuppressive Therapy in Kidney Transplantation
J. Pascual¹, C. Jiménez², M. Krajewska³, C. Kotton⁴, D. Seron⁵, J. Portolés⁶, O. Witzke⁷, S. S. Sorensen⁸, A. Andrés⁹, T. Díez¹⁰, A. Ortega¹⁰, I. Portero¹⁰
¹Consorci Mar Parc de Salut, Barcelona, Spain, ²La Paz Hospital, Madrid, Spain, ³Wroclaw Medical University, Wroclaw, Poland, ⁴Massachusetts General Hospital, Boston, MA, ⁵Vall d’Hebron Hospital, Barcelona, Spain, ⁶Puerta de Hierro Mahadahonda Hospital, Madrid, Spain, ⁷University Hospital Essen, University Duisburg-Essen, Essen, Germany, ⁸Rigshospitalet, Copenhagen, Denmark, ⁹12 de Octubre Hospital, Madrid, Spain, ¹⁰Biohope Scientific Solutions for Human Health SL, Madrid, Spain
*Purpose: Immunobiogram (IMBG) is a first-in-class blood-based pharmacodynamic immunoassay that provides the sensitivity/resistance profile of each patient’s lymphocytes to a panel of immunosuppressive drugs (IS).…
2020 American Transplant Congress
Clinical Significance of T Cell and B Cell Epitope Prediction as a Risk Factor of De Novo DSA Production after Kidney Transplantation
T. Kobayashi¹, K. Iwasaki¹, T. Tomosugi², Y. Miwa¹, M. Niemann³, E. Spierings⁴, K. Horimi¹, Y. Matsuoka¹, A. Takeda², N. Goto², S. Narumi², Y. Watarai²
¹Aichi Medical University School of Medicine, Nagakute, Japan, ²Nagoya Daini Red Cross Hospital, Nagoya, Japan, ³PIRCHE AG, Berlin, Germany, ⁴UMC Utrecht, Utrecht, Netherlands
*Purpose: Chronic antibody-mediated rejection caused by de novo DSA (dnDSA) is a major cause of graft failure. Risk prediction of dnDSA would be important for…
2020 American Transplant Congress
Longer-Term Outcomes from the THINKER and EXPANDER Trials of Transplantation Using HCV-Viremic Kidneys
V. S. Potluri¹, F. Naqvi², P. Reese¹, M. Shah¹, D. Brown², S. Prenner¹, A. Loupy³, A. Woodards¹, P. Abt¹, E. Blumberg¹, J. Trofe-Clark¹, D. Segev², R. Bloom¹, D. Sawinski¹, C. Durand², P. Porrett¹, M. Levine¹, D. Goldberg⁴, N. Desai²
¹University of Pennsylvania, Philadelphia, PA, ²Johns Hopkins, Baltimore, MD, ³Paris Transplant Group, Paris, France, ⁴University of Miami, Miami, FL
*Purpose: The practice of transplanting HCV-viremic kidneys into HCV-negative recipients has become more common, but longer-term outcomes have not been reported. We present data on…
2020 American Transplant Congress
Outcomes Associated with Mycophenolate Weight-Based Dosing in Varying Immunologic Risk Kidney Transplant Recipients
A. A. Al-Bahou, A. R. Webb, M. Bloxam, L. J. Bowman Anger, R. S. Baliga, A. J. Brueckner
Tampa General Hospital, Tampa, FL
*Purpose: Mycophenolate acid (MPA) is traditionally dosed in kidney transplant recipients (KTR) using the FDA-approved fixed dosing which is irrespective of patient-specific variables such as…
2020 American Transplant Congress
Recurrent Lupus Post Kidney Transplantation- The Histological and Clinical Characteristics
A. Bentall¹, W. Jiqiu², A. Kattah¹, M. L. Gonzalez Suarez³, F. G. Cosio¹, M. Mai⁴, H. Khamash⁵, M. D. Stegall⁶, H. Amer¹, L. D. Cornell⁷, F. Fervenza¹, M. P. Alexander⁷
¹Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, ²National Clinical Research Center of Kidney Diseases, Nanjing University, Nanjing, China, ³Department of Nephrology, University of Mississippi Medical Center, Jackson, MS, ⁴Division of Nephrology and Hypertension, Mayo Clinic, Jackonville, FL, ⁵Division of Nephrology and Hypertension, Mayo Clinic, Scottdale, AZ, ⁶Department of Transplant Surgery, Mayo Clinic, Rochester, MN, ⁷Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
*Purpose: Lupus nephritis (LN) progresses to ESRD in
2020 American Transplant Congress
Early Experience Transplanting Undocumented Immigrants with ESRD at a Single Institution: Outcomes and Challenges
R. T. Christie¹, R. M. Nygaard², C. J. Richardson¹, M. J. Hill¹, T. Anderson-Haag³, A. Israni⁴, P. A. Stahler¹
¹Transplant Surgery, Hennepin Healthcare, Minneapolis, MN, ²Surgery, Hennepin Healthcare, Minneapolis, MN, ³Transplant Pharmacy, Hennepin Healthcare, Minneapolis, MN, ⁴Nephrology, Hennepin Healthcare, Minneapolis, MN
*Purpose: In July of 2016, Minnesota became the second state in the nation to provide coverage for kidney transplantation to patients, regardless of immigration status,…
2020 American Transplant Congress
Outcomes of Kidney Retransplantation after Post-Transplant Lymphoproliferative Disorders: An Analysis of the UNOS/OPTN Database (1998 to 2019)
W. Cheungpasitporn¹, C. Thongprayoon², C. C. Jadlowiec³, W. J. Chon⁴, L. S. Cummings⁴, S. R. Katari⁴, N. Leeaphorn⁴
¹Nephrology, University of Mississippi Medical Center, Jackson, MS, ²Nephrology and Hypertension, Mayo Clinic, Rochester, MN, ³Transplant Surgery, Mayo Clinic, Phoenix, AZ, ⁴Renal Transplant Program, University of Missouri-Kansas City School of Medicine/Saint Luke's Health System, Kansas City, MO
*Purpose: Post-transplant lymphoproliferative disease (PTLD) is a serious, potentially fatal complication after kidney transplantation. Existing literature on outcomes of kidney retransplantation in patients with prior…
2020 American Transplant Congress
Post-Operative Delirium and Cognitive Decline in Kidney Transplant Recipients
N. Chu, D. Segev, M. McAdams Demarco
Johns Hopkins, Baltimore, MD
*Purpose: Post-operative delirium may be a marker for greater cognitive vulnerability to stressors. As a result, those with post-operative delirium may experience steeper decline in…