Articles tagged "Kidney transplantation"

2020 American Transplant Congress
Femto Pulse Analysis of Exosome RNA from Plasma of Renal Transplant Patients Confirmed the Unique Benefits of Plasma Exosome for Messenger RNA (mRNA) Transcript Analysis
H. Zhang¹, K. Wong², S. C. Jordan³, D. Warzak², M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, ²Agilent Technologies, Inc., Ankeny, IA, ³Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Previously, we reported the feasibility of measuring the mRNA transcript levels of various genes in plasma exosomes of renal transplant patients for prediction of…
2020 American Transplant Congress
Diagnostic Method of Acute Kidney Rejection after Transplantation Using Metabolome Analysis via a Liquid Biopsy Approach
H. Iwamoto
Department of Kidney Transplantation Surgery, Tokyo Medical University, Hachioji Medical Center, Tokyo, Japan
*Purpose: At present, a definitive diagnosis of organ dysfunction after transplantation (such as acute rejection) is dependent on conventional histopathological evaluation using an invasive biopsy…
2020 American Transplant Congress
A Multicenter, Randomized, Controlled Trial to Steer Immunosuppressive Therapy by Virus-Specific T Cells after Pediatric Kidney Transplantation (IVIST-Trial)
T. Ahlenstiel-Grunow¹, A. Großhennig¹, R. Schild², J. Oh², C. Taylan³, L. Weber³, H. Staude⁴, M. Verboom¹, C. Schröder¹, R. Sabau¹, A. Koch¹, X. Liu¹, L. Pape¹
¹Hannover Medical School, Hannover, Germany, ²University Hospital Hamburg-Eppendorf, Hamburg, Germany, ³University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany, ⁴University Hospital of Rostock, Rostock, Germany
*Purpose: Pharmakokinetic monitoring of immunosuppressants alone is insufficient to estimate the individual intensity of immunosuppression after kidney transplantation (Tx). Virus-specific T cells (Tvis) correlate with…
2020 American Transplant Congress
The Banff Classification of Antibody-Mediated Rejection in Kidney Allografts: Comparison of Predictive Performance for Allograft Failure in Previous and Current Editions
J. Callemeyn¹, H. Ameye¹, M. Coemans¹, A. Senev², E. Lerut³, B. Sprangers¹, D. Kuypers¹, M. Emonds², M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²Histocompatibility and Immunogenetics Laboratory, Red Cross-Flanders, Mechelen, Belgium, ³Imaging and Pathology, KU Leuven, Leuven, Belgium
*Purpose: Since its introduction in 2001, the Banff classification for antibody-mediated rejection (ABMR) has undergone significant changes, mainly by inclusion of C4d-negative ABMR in 2013…
2020 American Transplant Congress
Molecular Features of HLA Mismatches as Predictors of De Novo DSA Development: A Single Center Experience
V. Jucaud¹, L. Rebellato², K. Briley², C. Haisch², S. Kendrick³, H. Jones³, K. Mclawhorn³, D. Leeser², M. Everly¹
¹Terasaki Research Institute, Los Angeles, CA, ²East Carolina University, Greenville, NC, ³Eastern Nephrology Associates, Greenville, NC
*Purpose: Several molecular features (MoFs) of HLA mismatches (MMs) are currently used to predict the development of de novo donor-specific anti-HLA antibodies (dnDSA). The purpose…
2020 American Transplant Congress
Gender Disparity in Living Donor Kidney Transplants
A. Gruessner, S. Saggi, J. Renz, M. Markell, M. Salifu, R. Gruessner
SUNY Downstate Medical Center, Brooklyn, NY
*Purpose: Over the last decades, the number of kidney transplants has increased. However, more male than female patients receive a transplant. While the male/female ratio…
2020 American Transplant Congress
Kidney Alkalization Increases Macula Densa NOS1β Expression and Improves Transplanted Renal Graft Function
J. Buggs¹, J. Zhang², J. Wei², L. Wang²
¹Transplant Surgery, Tampa General Hospital, Tampa, FL, ²Molecular Pharmacology & Physiology, University of South Florida, Morsani College of Medicine, Tampa, FL
*Purpose: Ischemia-reperfusion injury (IRI) is a major survival hurdle with kidney transplantation (KTX). Currently, no effective strategies for the prevention and treatment of IRI during…
2020 American Transplant Congress
Low Physiochemical Immunogenicity Scores Improve Long-Term Survival of Deceased Donor Kidney Transplants
D. Bekbolsynov¹, B. Mierzejewska¹, J. Borucka², S. A. Khuder¹, M. Rees¹, R. Green³, S. Stanislaw¹
¹University of Toledo, Toledo, OH, ²Parexel Corp., Warsaw, Poland, ³Bowling Green State University, Bowling Green, OH
*Purpose: A severe shortage of deceased donor kidneys limits access to kidney transplantation. Limited longterm graft function exacerbates this shortage as 12% of the waiting…
2020 American Transplant Congress
The Impact of Purposeful Reductions in Immunosuppression on Clinical Outcomes in Kidney Transplantation
K. Foster, H. Perkins, N. Patel, C. Perez, N. Pilch, H. Meadows, F. Bartlett, V. Rao, M. Casey, M. Posadas Salas, K. Soliman, J. McGillicuddy, D. Taber
MUSC Health, Charleston, SC
*Purpose: Reductions to immunosuppressive therapy (IS) are often made due to infection or other IS intolerances, but little is known of impact of these reductions…
2020 American Transplant Congress
Early Post-Transplant Infusion of Ex Vivo-Expanded Autologous Polyclonal Regulatory T Cells (Treg) Prolongs Kidney Allograft Survival in Non-Lymphodepleted, CTLA4Ig-Treated Rhesus Monkeys
K. Sasaki, Y. Wang, R. Nakano, L. Lu, J. Hughes, V. Vujevich, A. J. Ganoza, M. Wijkstrom, A. Humar, A. W. Thomson, M. B. Ezzelarab
Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA
*Purpose: Rodent studies have demonstrated the utility of regulatory T cell (Treg) infusion for the promotion of tolerance to organ allografts. Here, we evaluated the…