Articles tagged "Kidney transplantation"

2020 American Transplant Congress
The Effect of B Cell Depletion Therapies on Preformed Xenoantibodies in Transplant Recipient
S. Yeh¹, N. A. Wilson², A. Djamali², R. Redfield³
¹Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, ²Medicine/Nephrology, University of Wisconsin-Madison, Madison, WI, ³Surgery, University of Wisconsin-Madison, Madison, WI
*Purpose: To assess the effect of B cell depletion therapies on preformed xenoantibodies in transplant recipient. Preformed xenoantibodies are a significant barrier to successful xenotransplantation.…
2020 American Transplant Congress
Combined Phenotyping to Identify Kidney Transplants at Greatest Risk after Subclinical Acute Rejection
S. Park¹, R. Heilman², E. Poggio³, D. Taber⁴, L. Zhao¹, K. Guo¹, S. Kurian⁵, C. Rebello¹, S. Brietigam¹, M. Abecassis⁶, J. Friedewald¹
¹Northwestern University, Chicago, IL, ²Mayo Clinic, Scottsdale, AZ, ³Cleveland Clinic, Cleveland, OH, ⁴MUSC, Charleston, SC, ⁵Scripps, La Jolla, CA, ⁶University of Arizona, Tucson, AZ
*Purpose: We hypothesize that the combination of protocol biopsy histology and gene expression profiles (GEP) for subclinical acute rejection (subAR) in the blood will improve…
2020 American Transplant Congress
The Role of Galectin-1 and Basement Membrane Remodeling in Kidney Antibody-Mediated Rejection
S. Clotet-Freixas¹, C. McEvoy¹, I. Batruch², M. Kotlyar³, C. Pastrello³, J. Van¹, M. Arambewela¹, A. Boshart¹, S. Farkona¹, A. Bozovic⁴, V. Kulasingam⁴, P. Chen¹, I. Jurisica³, A. Chruscinski¹, R. John⁴, A. Konvalinka⁵
¹Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, ²Department of Laboratory Medicine and Pathobiology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada, ³Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁴Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada, ⁵Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada
*Purpose: Antibody-mediated rejection (AMR), the leading cause of kidney graft loss, is caused by anti-HLA and non-HLA antibodies against proteins in two main kidney compartments:…
2020 American Transplant Congress
Long Term Outcomes of Hypertensive Kidney Donors
H. Ibrahim, S. Hebert, H. E. Adrogue, D. T. Nguyen, E. A. Graviss, A. Gaber, A. Matas
Houston Methodist Hospital, Houston, TX
*Purpose: Many people with hypertension are excluded from kidney donation fearing that hypertension is a major cause of CKD and its impact maybe magnified after…
2020 American Transplant Congress
Impact of Severity of Glomerulosclerosis on Long-Term Outcomes in Deceased Donor Renal Transplant Recipients with Donor Acute Kidney Injury
A. Brar¹, A. Gruessner², D. Adey¹, M. Salifu²
¹University of California, San Francisco, San Francisco, CA, ²SUNY Downstate Medical Center, Brooklyn, NY
*Purpose: With long waitlist times for renal transplantation,there is a need to reduce discard rates of donor kidneys.The purpose of this study is to assess…
2020 American Transplant Congress
Long-Term Outcomes for the Use of Native Small Capacity, Defunctionalized Bladders in Pediatric Kidney Transplantation
P. Vuong, A. Brubaker, L. Maestretti, W. Concepcion, A. Gallo
Stanford University Medical Center, Palo Alto, CA
*Purpose: Small capacity, defunctionalized urinary bladders present a challenge in pediatric kidney transplantation due to the inability to perform an adequate anti-reflux ureterocystostomy in a…
2020 American Transplant Congress
Multi- National Survey among Nephrologists & Transplant Surgeons About the Suitability and Acceptance of the Marginal Live Kidney Donors with Sickle Cell Trait
Z. Arabi¹, A. Mateen¹, A. Altheaby¹, M. Bukhari², A. Hamad³, S. Kaysi⁴, E. Elhassan¹
¹KAMC, Riyadh, Saudi Arabia, ²Taif University, Taif, Saudi Arabia, ³The Regional Medical Center, Orangeburg, SC, ⁴CHU Clermont-Ferrand, Saint Pryv/ Saint Mesmin, France
*Purpose: Due to organ shortage, many transplant centers may consider “marginal” kidney donors as those with sickle cell trait ( SCT) for donation. Acceptance of…
2020 American Transplant Congress
Frailty Predicts Increased Length of Stay after Kidney Transplantation: An Implementation Study
J. Schaenman, B. Hale-Durbin, C. Lee, N. Ventigan, S. Jaladanki, L. Shih, B. Abdalla, R. Ahn, S. Chang, M. Dunbar-Forrest, H. A. Gritsch, G. Danovitch, D. Goldwater
David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: Our objective was to implement a standardized an assessment of physical frailty and other aging-associated syndromes during routine evaluation of kidney transplant candidates over…
2020 American Transplant Congress
Transmission of Synovial Sarcoma by a Single Multiorgan Donor to Three Solid Organ Transplant Recipients
J. Zhang, J. Lin, Y. Tian
Beijing Friendship Hospital, Capital Medical University, Beijing, China
*Purpose: To report 3 cases of donor-derived synovial sarcoma (SS) by a single multiorgan donor in China.*Methods: SS was diagnosed by the presence of SS18…
2020 American Transplant Congress
Immune Checkpoint Inhibitor Use in Kidney Transplant Recipients: Rejection Risk, Prevention and Transcriptional Signature in Allograft
N. Murakami¹, G. Reid², A. Weins¹, B. Adam², M. Mengel², L. Riella¹
¹Brigham and Women's Hospital, Boston, MA, ²University of Alberta, Edmonton, AB, Canada
*Purpose: Immune checkpoint inhibitor (ICI) use has changed the landscape of cancer treatment. Several cases of acute rejection in use of ICI have been reported,…