Articles tagged "Kidney transplantation"

2020 American Transplant Congress
The Impact of Purposeful Reductions in Immunosuppression on Clinical Outcomes in Kidney Transplantation
K. Foster, H. Perkins, N. Patel, C. Perez, N. Pilch, H. Meadows, F. Bartlett, V. Rao, M. Casey, M. Posadas Salas, K. Soliman, J. McGillicuddy, D. Taber
MUSC Health, Charleston, SC
*Purpose: Reductions to immunosuppressive therapy (IS) are often made due to infection or other IS intolerances, but little is known of impact of these reductions…
2020 American Transplant Congress
Early Post-Transplant Infusion of Ex Vivo-Expanded Autologous Polyclonal Regulatory T Cells (Treg) Prolongs Kidney Allograft Survival in Non-Lymphodepleted, CTLA4Ig-Treated Rhesus Monkeys
K. Sasaki, Y. Wang, R. Nakano, L. Lu, J. Hughes, V. Vujevich, A. J. Ganoza, M. Wijkstrom, A. Humar, A. W. Thomson, M. B. Ezzelarab
Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA
*Purpose: Rodent studies have demonstrated the utility of regulatory T cell (Treg) infusion for the promotion of tolerance to organ allografts. Here, we evaluated the…
2020 American Transplant Congress
Protocolized Exercise Improves Frailty Parameters and Lower Extremity Impairment: A Promising Prehabilitation Strategy for Kidney Transplant Candidates
E. C. Lorenz, L. J. Hickson, R. Weatherly, K. Thompson, H. Walker, J. Rasmussen, T. Stewart, J. Garrett, C. C. Kennedy
Mayo Clinic, Rochester, MN
*Purpose: Frailty and lower extremity (LE) impairment are risk factors for numerous adverse outcomes in kidney transplant (KT) candidates, including decreased rates of transplantation, increased…
2020 American Transplant Congress
Role of Innate Allorecognition Pathways in Mouse Kidney and Heart Allograft Rejection
D. Zhao¹, H. Dai¹, K. Abou-Daya¹, R. Tieu¹, A. Williams¹, M. Oberbarnscheidt¹, X. Li², F. Lakkis¹
¹Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, ²Houston Methodist Hospital Immunobiology & Transplant Science Center, Houston, TX
*Purpose: Paired immunoglobulin-like receptors (PIR) and CD47 are molecules expressed on host myeloid cells. They recognize donor polymorphic MHC and signal regulatory protein alpha (SIRPα),…
2020 American Transplant Congress
Pretransplant BKV-IgG Serostatus and BKV-Specific ELISPOT Assays for the Prediction of BKV Infection
H. Bae¹, J. Jang¹, H. Lee², S. Yun¹, E. Oh³
¹Department of Biomedical Science, Graduate School, Catholic University of Korea, Seoul 137-040, Korea, Republic of, ²Department of Laboratory Medicine, Catholic Kwandong University of Korea, Incheon, Korea, Republic of, ³Department of Laboratory Medicine, Catholic University of Korea, Seoul 137-040, Korea, Republic of
*Purpose: BK Polyomavirus (BK) can lead to major infectious complications and damage to the graft in kidney transplantation (KT). We investigated whether pretransplant BK serostatus…
2020 American Transplant Congress
Frailty-Inflammatory Index & Mortality after Kidney Transplantation: Development & Validation
N. Chu, C. Haugen, D. Segev, M. McAdams-DeMarco
Johns Hopkins, Baltimore, MD
*Purpose: Frailty is associated with poor outcomes like delirium, delayed graft function, and mortality, that may result from inflammation after kidney transplant (KT). Despite a…
2020 American Transplant Congress
Characterizing the Landscape and Impact of Infections Following Kidney Transplantation
K. R. Jackson, J. Motter, R. Avery, W. Werbel, A. Massie, J. Garonzik-Wang, D. Segev
Johns Hopkins University, Baltimore, MD
*Purpose: Infections remain a major threat to successful kidney transplantation (KT), although there is limited data on the spectrum and clinical consequences of a post-KT…
2020 American Transplant Congress
Safety Outcomes in Lower-Weight vs Higher-Weight Recipients of Fixed Dose Alemtuzumab for Kidney Transplant Induction
A. Freeman, S. Anders, B. Wise, M. Janusek, L. Hutchinson, U. Kaszubski, D. Marroquin, D. Martin, H. Bohorquez
Ochsner Medical Center, New Orleans, LA
*Purpose: Alemtuzumab is a lymphocyte-depleting monoclonal antibody used for renal transplant induction, and is associated with significant leukopenia, increased infections and malignancy. Multiple dosing strategies…
2020 American Transplant Congress
Time-Trend of Metabolic Risks in Living Kidney Donors in South Korea
E. Kang¹, J. Park¹, S. Park¹, Y. Kim², J. Jeong³, J. An⁴, S. Lee⁵, S. Kim⁶, J. Cho⁷, M. Han⁸, H. Lee¹
¹Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ²Internal Medicine, Keimyung University Dongsan Hospital, Daegu, Korea, Republic of, ³Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea, Republic of, ⁴Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea, Republic of, ⁵Internal Medicine, Chonbuk National University Hospital, Jeonju, Korea, Republic of, ⁶Internal Medicine, Chonnam National University Hospital, Gwangju, Korea, Republic of, ⁷Internal Medicine, Kyungpook National University, Seoul, Korea, Republic of, ⁸Internal Medicine, Pusan National University Hospital, Pusan, Korea, Republic of
*Purpose: Considering westernized lifestyles and increasing prevalence of chronic diseases occurred in Korea, time-trend exploration of metabolic risk in live kidney donors may help to…
2020 American Transplant Congress
Predicting Renal Graft Function Post Transplantation Using Clinical and Biological Features Supported by Machine Learning Algorithms
Y. Gao¹, Y. Cui¹, C. Kuscu², C. Kuscu², L. Gallon³, A. Bajwa², E. Akalin⁴, J. D. Eason², D. Maluf², V. Mas²
¹Department of Genetics, University of Tennessee Health Science Center, Memphis, TN, ²Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN, ³Northwestern University, Chicago, IL, ⁴Albert Einstein Medical College, New York, NY
*Purpose: Predicting renal function post transplantation is a frequent challenge impacting physician decisions and patient quality of life. We aimed to develop a composite score…