Articles tagged "Kidney transplantation"

2020 American Transplant Congress
Noninvasive Detection of Subclinical Rejection in Urine RNA
K. S. Keslar¹, D. Margeta¹, J. J. Friedewald², M. Abecassis², R. B. Mannon³, P. S. Heeger⁴, R. L. Fairchild¹
¹Cleveland Clinic, Cleveland, OH, ²Northwestern University, Chicago, IL, ³University of Alabama at Birmingham, Birmingham, AL, ⁴Icahn School of Medicine, New York, NY
*Purpose: Subclinical rejection may lead to long-term graft injury and can currently only be detected by repeated biopsies. A noninvasive method is needed to monitor…
2020 American Transplant Congress
HLA Molecular Mismatch Analysis in Recipients of Kidney Plus Hematopoietic Stem/Facilitating Cell Transplant Tolerance Induction Protocol
C. Garcia-Sanchez¹, V. Kosmoliaptsis², H. Copley², J. Leventhal¹, S. Ildstad³
¹NU, Chicago, IL, ²Cambridge, Cambridge, United Kingdom, ³U of Louisville, Lousville, KY
*Purpose: To evaluate the potential role of HLA molecular mismatch (MM) analysis in predicting outcomes in a cohort of HLA-mismatched, related and unrelated recipients of…
2020 American Transplant Congress
The Association between Alloimmunity and De Novo Glomerulonephritis Post Kidney Transplantation
P. Khairallah, J. Kamal, E. Vasilescu, I. Batal, G. Dube
Columbia University Medical Center, New York, NY
*Purpose: In contrast to recurrent immune complex-mediated glomerulonephritis (ICGN), de novo ICGN of the allograft is poorly characterized. We hypothesize that alloimmunity results in immune-complex…
2020 American Transplant Congress
Missing Self Increases the Incidence of Microvascular Inflammation after Kidney Transplantation
J. Callemeyn¹, A. Senev², M. Coemans¹, E. Lerut³, B. Sprangers¹, D. Kuypers¹, A. Koenig⁴, O. Thaunat⁴, M. Emonds², M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²Histocompatibility and Immunogenetics Laboratory, Red Cross-Flanders, Mechelen, Belgium, ³Imaging and Pathology, KU Leuven, Leuven, Belgium, ⁴INSERM U1111, Université Claude Bernard Lyon I, Lyon, France
*Purpose: Anti-HLA donor-specific antibodies (HLA-DSA) are often absent in serum of kidney allograft recipients with biopsies demonstrating microvascular inflammation (MVI), the histological hallmark of antibody-mediated…
2020 American Transplant Congress
T and B Lymphocyte Dynamics after Genetically-Modified Pig-To-Baboon Kidney Xenotransplantation with an Anti-CD40mAb-Based Immunosuppressive Regimen
A. Jagdale¹, H. Iwase¹, H. Nguyen¹, T. Yamamoto¹, D. Ayares², D. Anderson¹, D. Eckhoff¹, D. Cooper¹, H. Hara¹
¹Surgery, University of Alabama at birmingham, Birmingham, AL, ²Revivicor, Blacksburg, VA, VA
*Purpose: We have evaluated recovery of T and B lymphocytes and their subsets after depletion by anti-thymocyte globulin (ATG) and an anti-CD20mAb (Rituximab), followed by…
2020 American Transplant Congress
Timing of Bariatric Surgery for Obese Kidney Transplant Candidates
R. A. Choudhury¹, D. Yoeli¹, G. Hoeltzel², H. B. Moore¹, H. Yaffe¹, K. R. Dumon³, N. N. Williams³, P. L. Abt⁴, K. D. Conzen¹, T. Pshak¹, P. T. Kennealey¹, T. L. Nydam¹
¹Department of Surgery- Division of Transplantation Surgery, University of Colorado Hospital, Aurora, CO, ²Thomas Jefferson University Hospital, Philadelphia, PA, ³Department of Surgery, University of Pennsylvania Hospital, Philadelphia, PA, ⁴Department of Surgery- Division of Transplantation Surgery, University of Pennsylvania Hospital, Philadelphia, PA
*Purpose: The high risk profile of bariatric surgery in obese end-stage-renal disease (ESRD) patients has caused many to suggest that surgery should be reserved for…
2020 American Transplant Congress
Outcomes and Health Care Utilization after Early Hospital Dismissal in Kidney Transplantation: An Analysis of 1001 Consecutive Cases
E. Calderon¹, Y. Chang², J. M. Chang¹, C. Velazco¹, E. Giorgakis¹, A. A. Moss¹, H. Khamash³, R. Heilman³, K. S. Reddy¹, A. K. Mathur¹
¹Transplant Surgery, Mayo Clinic, Phoenix, AZ, ²Kern Center for the Science of Health Care Delivery, Mayo Clinic, Phoenix, AZ, ³Department of Nephrology, Mayo Clinic, Phoenix, AZ
*Purpose: Perioperative care after kidney transplantation has improved with reduction in length of operative stay to as low as two days, but this has an…
2020 American Transplant Congress
Outcomes Analysis of Transplant Centers Performing High Volumes of Hard to Place Kidneys: An Update
D. Bahl¹, N. Mehta², Y. A. Qazi³
¹School of Medicine, St. George's University, West Indies, Grenada, ²University of California, Berkeley, Torrance, CA, ³School of Medicine, Keck Medicine of USC, Los Angeles, CA
*Purpose: Despite a growing number of patients awaiting a kidney transplant, the discard rate remains significantly high. The UNOS SRTR data now provides information on…
2020 American Transplant Congress
A Prospective Randomized Multicenter Trial (BEST Trial) of Belatacept-Based CNI- and Corticosteroid-Free Immunosuppression: Infectious Complications
P. West-Thielke¹, A. Shields², D. Kaufman³, J. Leone⁴, A. Wiseman⁵, A. Matas⁶, T. Sa⁷, E. King⁷, R. Alloway², S. Woodle²
¹University of Illinois, Chicago, IL, ²University of Cincinnati, Cincinnati, OH, ³University of Wisconsin, Madison, IL, ⁴Tampa General Hospital, Tampa, FL, ⁵University of Colorado, Aurora, CO, ⁶University of Minnesota, Minneapolis, MN, ⁷Cincinnati Children's Hospital Medical Center, Cincinnati, OH
*Purpose: The BEST Trial (Belatacept-based Early Steroid Withdrawal Trial) is a prospective, randomized, multi-center trial designed to compare two belatacept (BELA)-based calcineurin inhibitor-free (CNI), early…
2020 American Transplant Congress
Donor-Derived DCREG Infusion Prolongs Kidney Allograft Survival in Rhesus Monkeys Treated with Co-Stimulation Blockade and Calcineurin Inhibition
Y. Wang, S. Kazuki, L. Lu, A. Zahorchak, H. Dai, A. Ganoza, M. Wijkstrom, A. Humar, M. Ezzelarab, A. Thomson
Thomas E. Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: We have shown previously that pre-transplantation (Tx) infusion of donor-derived regulatory dendritic cells (DCreg) safely prolongs MHC-mismatched renal allograft survival and regulates donor-reactive T…