Articles tagged "Kidney transplantation"

2020 American Transplant Congress
Anti-Thymocyte Globulins Induced Immunomodulatory Effect and Increased Regulatory T Cell in a In Vitro Model of Allogeneic Cell Coculture
M. Colladant¹, J. Lion², P. Saas³, S. Perruche³, D. Ducloux¹, N. Mooney², J. Bamoulid¹
¹Nephrologie, Dialyse et Transplantation, CHU de Besançon, Besancon, France, ²Equipe INSERM: Endothelium, Inflammation et Alloreactivity INSERM UMR-S 976, Paris, France, ³INSERM U1098 RIGHT, Université de Franche-Comté EFS Bourgogne Franche-Comté, Besancon, France
*Purpose: Two types of Anti-Thymocyte Globulins (ATG) are commonly used in renal transplantation (Thymoglobuline and Grafalon) and induce severe, dose-dependent and sometimes persistent CD4+ T…
2020 American Transplant Congress
Tissue Resident Memory T Cells in Mouse Renal Transplantation
K. Abou-Daya¹, D. Zhao¹, R. Tieu¹, R. Rammal², M. Oberbarnscheidt¹, F. Lakkis¹
¹Starzl Transplantation Institute, Pittsburgh, PA, ²American University of Beirut, Beirut, Lebanon
*Purpose: The newly identified tissue resident subset of memory T cells (TRM) provides immune surveillance in the tissue and first response against infections. They are…
2020 American Transplant Congress
Deceased Donors in Kidney Paired Donation
J. D. Kalbfleisch¹, W. Wang¹, M. A. Rees², A. B. Leichtman³, P. X. Song¹, V. Ashby¹, T. Shearon¹
¹Biostatistics, University of Michigan, Ann Arbor, MI, ²University of Toledo, Toledo, OH, ³University of Michigan, Ann Arbor, MI
*Purpose: A kidney paired donation pool (KPDP) consists of transplant candidates and their incompatible living donors along with nondirected living donors (NDDs). In a match…
2020 American Transplant Congress
Prospective, Randomized Study of Conversion from Calcineurin Inhibitor (CNI)- to Belatacept (BELA)-Based Maintenance Immunosuppression in Renal Transplant Recipients
K. Budde¹, R. Prashar², H. Haller³, M. Rial⁴, N. Kamar⁵, A. Agarwal⁶, J. de Fijter⁷, L. Rostaing⁸, S. Berger⁹, A. Djamali¹⁰, N. Leca¹¹, L. Allamassey¹², S. Gao¹², M. Polinsky¹², F. Vincenti¹³
¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²Henry Ford Hospital, Detroit, MI, ³The Hannover Medical School, Hannover, Germany, ⁴Instituto de Nefrologia, Nephrology SA, Buenos Aires, Argentina, ⁵University of Toulouse, Toulouse, France, ⁶UVA Health, Charlottesville, VA, ⁷Leiden University Medical Center, Leiden, Netherlands, ⁸Université Grenoble Alpes, Saint-Martin-d'Hères, France, ⁹University Medical Centre Groningen, Groningen, Netherlands, ¹⁰University of Wisconsin, Madison, WI, ¹¹UW Medical Center, Seattle, WA, ¹²Bristol-Myers Squibb, Princeton, NJ, ¹³University of California, San Francisco, San Francisco, CA
*Purpose: CNIs are associated with adverse systemic and nephrotoxic effects that negatively impact long-term patient and graft survival. In a phase 2 study, switching renal…
2020 American Transplant Congress
Pediatric Primary Kidney Transplant Recipients Outcomes by Immunosuppression Induction Received in the United States
S. M. Riad¹, S. Jackson², A. Matas³, S. Chinnakotla³, P. Verghese⁴
¹University of Minnesota, Minneapolis, MN, ²Complex Care Analytics, Fairview Health Services, Minneapolis, MN, ³Surgery, University of Minnesota, Minneapolis, MN, ⁴Pediatrics, University of Minnesota, Minneapolis, MN
*Purpose: Induction immunosuppression types for pediatric transplant recipients vary widely by transplant centers. We sought to study the impact of different induction types on recipients…
2020 American Transplant Congress
Survival of ESRD Patients with an EPTS > 90% Listed for Kidney Transplant
M. S. Sampaio¹, E. Lum¹, P. Homkrailas¹, G. Danovitch¹, H. Gritsch², S. Bunnapradist¹
¹UCLA - Division of Nephrology, Los Angeles, CA, ²UCLA - Division of Urology, Los Angeles, CA
*Purpose: Mortality on the kidney transplant waitlist is high especially in candidates with a high Estimated Post Transplant Survival (EPTS) score. We examined outcomes of…
2020 American Transplant Congress
Preferences of Potential Living Kidney Donors on Strategies to Reduce Donation-Related Financial Burden
A. D. Waterman¹, O. N. Ranasinghe¹, Y. Cui², J. L. Beaumont², D. Adey³, B. Campbell⁴, F. L. Weng⁵
¹Division of Nephrology, David Geffen School of Medicine, Los Angeles, CA, ²Terasaki Research Institute, Los Angeles, CA, ³UCSF Health, San Francisco, CA, ⁴Cedars Sinai Medical Center, Los Angeles, CA, ⁵St. Barnabas Medical Center, Livingston, NJ
*Purpose: To identify the severity of financial and employment challenges present for potential living kidney donors and the value of strategies to make kidney donation…
2020 American Transplant Congress
Survey of Clinician Opinions on Use of Organ Transplants from Hepatitis C Virus Positive Donors: Identifying & Overcoming Barriers
K. Lentine¹, T. Alhamad², D. Peipert³, Y. Caliskan¹, B. Concepcion⁴, R. Forbes⁴, M. Schnitzler¹, Z. Zhang¹, S. Chang², M. Cooper⁵, R. Bloom⁶, R. Mannon⁷, D. Axelrod⁸
¹Saint Louis U, Saint Louis, MO, ²Washington U, Saint Louis, MO, ³Northwestern, Chicago, IL, ⁴Vanderbilt, Nashville, TN, ⁵Georgetown, Washington, DC, ⁶U Penn, Philadelphia, MO, ⁷UAB, Birmingham, AL, ⁸U Iowa, Iowa City, IA
*Purpose: Increasing the use of Hepatitis C Virus (HCV) viremic (Nucleic Acid Testing (NAT)+) donor organs for HCV uninfected (HCV-) patients is a potential approach…
2020 American Transplant Congress
End-Hypothermic Oxygenated Machine Perfusion after Static Cold Storage versus Static Cold Storage Alone in Kidneys from Extended Criteria Brain-Dead Donors: An International Randomized Controlled Trial
P. Husen¹, C. Boffa², I. Jochmans³, C. Krikke⁴, L. Davies², H. Hofker⁴, J. Pirenne³, R. Ploeg², A. Paul¹
¹General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany, ²Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ³University Hospitals Leuven, Leuven, Belgium, ⁴University Medical Center Groningen, Groningen, Netherlands
*Purpose: A prospective, randomized, single-blinded, multicenter trial comparing the effect of short-term 'in house' oxygenated hypothermic machine preservation (End-HMPO2) following static cold storage (SCS) versus…
2020 American Transplant Congress
Impact of Dialysis and Diabetes on Survival in Recipients of Combined Heart-Kidney Transplant
J. Parekh¹, H. Chau², G. Schnickel², J. Berumen², K. Mekeel²
¹University of California, San Diego, La Jolla, CA, ²Surgery, University of California, San Diego, La Jolla, CA
*Purpose: Mounting data shows a survival benefit of combined heart-kidney transplantation in patients with heart and renal failure. However, little has been done to understand…