Articles tagged "Kidney transplantation"

2020 American Transplant Congress
Textbook Outcome as a Composite Quality Metric in Kidney Transplantation
J. L. Han, A. J. Logan, J. M. Sneddon, G. L. Brock, K. W. Washburn, A. D. Schenk
Department of Surgery, Division of Transplantation, The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: Textbook outcomes (TO) describe ideal patient outcomes following specific surgical procedures and are useful composite quality metrics for patients, providers and payors. We aimed…
2020 American Transplant Congress
Steroid Withdrawal and Lymphocyte Subsets in Graft Capillary Blood versus Peripheral Blood in Low Immunological Risk Kidney Transplant Patients: Randomized, Parallel Group, Controlled Clinical Trial
T. Vazquez Sanchez, A. Caballero, J. Alonso-Titos, V. Lopez, E. Sola, M. Cabello, E. Gutierrez Vilchez, M. Martínez-Esteban, P. Ruiz Esteban, J. Delgado, D. Hernandez
Regional University Hospital, Malaga, Spain
*Purpose: Whether steroid withdrawal can modulate the subclinical inflammatory response after a kidney transplant is unknown.*Methods: We undertook a controlled multicenter clinical trial involving 105…
2020 American Transplant Congress
Uremic Symptoms: A Patient-Reported Outcome That is Associated with Access to Kidney Transplantation and Waitlist Mortality among Kidney Transplant Candidates
K. Taylor¹, N. Chu², Z. Shi², E. Rosello³, S. Kunwar², P. Butz³, S. Norman⁴, D. Crews⁵, K. Greenberg⁵, D. Segev³, T. Shafi⁶, M. McAdams-DeMarco³
¹Johns Hopkins University School of Nursing, Baltimore, MD, ²Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD, ³Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Division of Nephrology, University of Michigan, Ann Arbor, MI, ⁵Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Division of Nephrology, University of Mississippi Medical Center, Jackson, MS
*Purpose: Patient-reported symptoms of uremia - pruritis, anorexia and fatigue - reflect incomplete removal of uremic toxins by dialysis and are likely one of the…
2020 American Transplant Congress
Targeted Urine Metabolomics for Monitoring Renal Allograft Injury and Immunosuppression
T. Sigdel, A. Schroeder, J. Y. Yang, R. Sarwal, J. Liberto, M. Sarwal
University of California San Francisco, San Francisco, CA
*Purpose: The purpose of this study was to apply high-throughput metabolomics and machine learning to identify surrogate urine metabolite biomarkers for acute rejection vs. BK…
2020 American Transplant Congress
Feasibilty of Hepatitis C NAT Positive Kidney Transplant into Hepatitis C Negative Recipients as Standard of Care
T. Kaur, J. Choi, N. Anwar, M. Anand, S. Shah, S. Bumb, B. Abu Jawdeh, S. Shah, T. Diwan, A. Govil
University of Cincinnati Medical Center, Cincinnati, OH
*Purpose: With advent of direct acting antivirals (DAA) for Hepatitis (Hep) C which have a 96-100% sustained viral remission(SVR), doors have opened for using Hep…
2020 American Transplant Congress
Tertiary Lymphoid Organs in Renal Chronic Allograft Rejection
K. Abou Daya, D. Zhao, K. Biery, M. Oberbarnscheidt
Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: Chronic allograft rejection remains a major obstacle to long-term allograft survival. Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in non-lymphoid tissues…
2020 American Transplant Congress
Center Effects Substantially Explain Disparities in Access to Kidney Transplants, Yet DSA Effects Remain
D. Stewart, A. Robinson, D. Klassen, A. Wilk
United Network for Organ Sharing, Richmond, VA
*Purpose: The OPTN developed a novel methodology in 2016 to monitor equity in access to deceased donor kidney transplants (Tx) among waitlisted candidates. Results have…
2020 American Transplant Congress
Prolonged In Vivo Perfusion of a Re-Endothelialized Human-Scale Tissue Engineered Kidney Graft
J. S. Uzarski¹, E. E. Russell¹, E. C. Beck¹, M. Holzner², V. Wadhera², D. Adamson², T. Gilbert¹, S. Florman², D. S. Davidow¹, R. Shapiro², J. Ross¹
¹Research & Development, Miromatrix Medical Inc., Eden Prairie, MN, ²Recanati/Miller Institute, Mount Sinai, New York, NY
*Purpose: Advances are desperately needed to increase the supply of transplantable kidneys for the 100,000 patients on the waiting list. Whole organ engineering is one…
2020 American Transplant Congress
Peak DSA Levels Pre-Transplant but Not at Transplant Predict Graft Survival
A. Y. Choi¹, D. Olaso¹, T. Risoli Jr², M. Kuchibhatla², Z. Fitch³, R. Schmitz³, P. M. Schroder³, A. Jackson³, M. Manook³, J. Yoon³, A. B. Farris⁴, J. Kwun³, S. J. Knechtle³
¹Duke University School of Medicine, Durham, NC, ²Duke Biostatistics, Epidemiology, and Research Design Core, Duke University, Durham, NC, ³Department of Surgery, Duke University Medical Center, Durham, NC, ⁴Department of Pathology, Emory University Hospital, Atlanta, GA
*Purpose: Immunization to major histocompatibility complex (MHC) antigens is a barrier in kidney transplantation (KTx) due to higher risk of antibody-mediated rejection (AMR) and graft…
2020 American Transplant Congress
Low-Dose Rabbit Antithymocyte Globulin Induction in Elderly Kidney Transplant Recipients at High Immunologic Risk is Safe and May Prevent Excess Rejection
E. Sartain¹, B. Nettles¹, B. Crowther¹, P. Klem¹, K. Schwarz¹, S. Davis²
¹University of Colorado Hospital, Aurora, CO, ²University of Colorado School of Medicine, Aurora, CO
*Purpose: Patients aged ≥65 years are a growing segment of kidney transplant recipients (KTRs). Consensus on induction immunosuppression in this population is unclear given higher…