Articles tagged "Kidney transplantation"

2020 American Transplant Congress
Clazakizumab (Anti-IL-6) Induces Foxp3+ Tregs in Highly HLA Sensitized Patients Desensitized for HLAi Transplantation (NCT03380962)
S. C. Jordan, S. Ge, N. Ammerman, M. Toyoda, E. Huang, A. Peng, R. Najjar, S. Sethi, S. Williamson, C. Myers, K. Lim, J. Choi, A. Vo
Cedars Sinai Medical Ctr, West Hollywood, CA
*Purpose: Interleukin-6 is an important inflammatory cytokine. In addition, it acts as a growth factor for B-cells, plasma cells and Th17 cells, inhibiting FoxP3+ Treg…
2020 American Transplant Congress
Infectious Complications in Elderly Kidney Transplant Recipients Undergoing Desensitization
S. Sethi, R. Najjar, A. Peng, A. Vo, S. Jordan, E. Huang
Cedars Sinai Medical Center, West Hollywood, CA
*Purpose: Data is limited on the impact of desensitization on infectious complications in elderly kidney transplant (KT) recipients. We examined infectious complications in elderly KT…
2020 American Transplant Congress
Accomplishment of Ischemia-Free Kidney Transplantation Using Normothermic Machine Perfusion
G. Chen, X. He, C. Wang, X. Yuan, M. Han, Z. Guo
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
*Purpose: Ischemia-reperfusion injury (IRI) has been considered an inevitable event in organ transplantation since the first successful kidney transplant was performed in 1954. To avoid…
2020 American Transplant Congress
Microvascular Inflammation without DSA or C4d: An Orphan Category in Banff Classification with Intense Capillaritis and Cytotoxic T-Cell Infiltration
A. Buxeda¹, L. Llinàs-Mallol², J. Gimeno³, C. Arias-Cabrales¹, C. Burballa¹, D. Redondo-Pachón¹, D. Raïch-Regué², M. Pérez-Sáez¹, J. Pascual¹, M. Crespo¹
¹Nephrology Department, Hospital del Mar, Barcelona, Spain, ²Nephrology Department, IMIM - Institute Hospital del Mar for Medical Research, Barcelona, Spain, ³Pathology Department, Hospital del Mar, Barcelona, Spain
*Purpose: Antibody-mediated rejection (ABMR) associated with donor-specific HLA antibodies (DSA) is the leading cause of late allograft failure after kidney transplantation. Microvascular inflammation (MVI) without…
2020 American Transplant Congress
Investigation of Il35 Expressing Regulatory B Cells in Tolerance of Kidney Transplantation
J. A. Sullivan, J. H. Fechner, E. Jankowska-Gan, W. J. Burlingham, D. B. Kaufman
Surgery, University of Wisconsin, Madison, WI
*Purpose: The development and maintenance of peripheral tolerance is required for long term success of solid organ transplantation without immuno-suppressive drugs. Using a novel, post-transplant,…
2020 American Transplant Congress
Trends in Living Kidney Donation in the United States
A. Ferzola, Y. Yu, A. B. Massie, D. L. Segev, M. L. Henderson
Johns Hopkins University, Baltimore, MD
*Purpose: After peaking in 2014, the number of LKDTs per year dropped substantially in the US despite an increasing waitlist. However, trends in the KAS…
2020 American Transplant Congress
UNOS Hard to Place Kidneys: Are We Working Too Hard?
S. Chaudhry, K. L. King, S. A. Husain, D. Cohen, L. Ratner, S. Mohan
Columbia University, New York, NY
*Purpose: Kidneys requiring more than 100 offers before acceptance are defined by UNOS as “hard to place," but many are suitable for transplantation. We sought…
2020 American Transplant Congress
Transient Cd4+ T Cell and Cd20+ B Cell Depletion Leads to Prolonged Pig-To-Primate Kidney Xenograft Survival
B. P. Lovasik¹, A. J. Matar¹, D. A. Faber¹, D. V. Mathews¹, C. Breeden¹, S. C. Kim¹, A. J. Tector², A. B. Adams¹
¹Emory University School of Medicine, Atlanta, GA, ²University of Miami, Miami, FL
*Purpose: “Delayed” antibody-mediated xenograft rejection is the one of the most important obstacle to clinical application of pig organ xenografts. The aim of this study…
2020 American Transplant Congress
Parathyroidectomy Post Kidney Transplant: A Single Center Report of Short Term Outcomes
S. Ong, F. Saad, K. Wille, C. Kew
University of Alabama at Birmingham, Birmingham, AL
*Purpose: Whether parathyroidectomy in ESRD patients should be performed before or after kidney transplant remains controversial. There is concern that post-transplant parathyroidectomy can adversely affect…
2020 American Transplant Congress
Peer Feedback Improves Nephrologists’ Transplant Referral Practices
A. Padiyar, T. Srinivas
Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH
*Purpose: While preemptive kidney transplant is associated with superior outcomes, timely referral remains a significant barrier. Peer feedback may help improve practice. Our hypothesis is…