Articles tagged "Kidney transplantation"

2020 American Transplant Congress
Donor Mesenchymal Stem Cells in Combination with Co-Stimulation Blockade Prolong Allograft Survival
A. J. Matar, B. P. Lovasik, S. C. Kim, C. A. Breeden, D. A. Faber, D. V. Mathews, J. Regenold, A. Ghosh, A. Stephenson, W. H. Kitchens, A. B. Adams
Surgery and Transplantation, Emory University, Atlanta, GA
*Purpose: Co-stimulation blockade (CoB) has emerged as a promising immunosuppression strategy and potential alternative to calcineurin inhibitors in solid organ transplantation. Despite recent advancements, CoB…
2020 American Transplant Congress
Evaluation of the Safety and Tolerability of Clazakizumab® as a Desensitization Agent in Highly-HLA Sensitized ESRD Patients (NCT03380962): 12m Follow-Up
A. A. Vo¹, N. Ammerman¹, E. Huang¹, M. Toyoda², S. Ge², A. Peng¹, R. Najjar¹, S. Williamson¹, C. Meyers¹, S. Sethi¹, K. Lim¹, J. Choi¹, S. C. Jordan¹
¹Kidney Transplant, Cedars Sinai Medical Ctr, Los Angeles, CA, ²Transplant Immunology Laboratory, Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: IL-6 mediates inflammation and activation of T-cells, B-cells & plasma cells. Thus, IL-6 may represent an important target for desensitization (DES). Here we report…
2020 American Transplant Congress
Single Dose Rituximab and Anti-Thymocyte Globulin (ATG) Induction in Hypersensitized Kidney Transplant Recipients
A. X. Wang, U. Wang, S. Busque, C. R. Lenihan
Stanford University School of Medicine, Stanford, CA
*Purpose: Hypersensitized kidney transplant recipients (calculated panel reactive antibody (cPRA) ≥98%) may represent a population at high risk of posttransplant immunologic events. While access to…
2020 American Transplant Congress
A Comparison of Kidney Paired Donation Education Delivery Across 68 National Kidney Registry-Affiliated Centers
A. Waterman¹, E. H. Wood¹, O. N. Ranasinghe¹, J. L. Beaumont², S. McGuire³, K. Miller⁴, V. Chipman⁵, J. Sinacore⁶, M. Cooper⁷
¹Division of Nephrology, David Geffen School of Medicine, Los Angeles, CA, ²Terasaki Research Institute, Los Angeles, CA, ³UCLA Kidney and Pancreas Transplant Programs, Los Angeles, CA, ⁴UW Health, Madison, WI, ⁵UCSF Medical Center, San Francisco, CA, ⁶National Kidney Registry, Babylon, NY, ⁷Medstar Georgetown Transplant Institute, Washington, DC
*Purpose: To understand the kidney paired donation (KPD) educational delivery process and variation across centers affiliated with the National Kidney Registry (NKR) we surveyed transplant…
2020 American Transplant Congress
Utilization of Hepatitis C Positive Organs in Kidney Transplantation
J. Mandel, U. Kaszubski, A. Freeman, L. Hutchinson, M. Janusek, C. Reuter, C. Velasco, B. Wise, S. Anders, E. Bugeaud
Ochsner Medical Center, New Orleans, LA
*Purpose: The efficacy of direct acting antivirals (DAAs) in HCV has cleared the path for the use of HCV positive donor kidneys into negative recipients.…
2020 American Transplant Congress
Validation of New Measures of Self-Efficacy and Decision-Making for Living Donors
A. D. Waterman¹, D. Peipert², J. L. Beaumont³, F. Weng⁴
¹Transplant Research and Education Center, Los Angeles, CA, ²Feinberg School of Medicine, Northwestern University, Chicago, IL, ³Terasaki Research Institute, Los Angeles, CA, ⁴St. Barnabas Medical Center, Livingston, NJ
*Purpose: Kidney transplants from living donors (LD) impart the best clinical outcomes but have declined substantially over the past 15 years. To intervene with LDs…
2020 American Transplant Congress
Lymphoceles in Kidney Transplant Recipients: Incidence, Risk Factors, Outcomes, and Clinical Management
J. Kim, E. Nguyen, M. Minkovich, O. Famure, Y. Li, J. Lee
Toronto General Hospital, Toronto, ON, Canada
*Purpose: Post kidney transplantation, lymphocele development can result in morbidity for the patient and graft. Lacking prior studies in a representative cohort, we aimed to…
2020 American Transplant Congress
Longitudinal Study Investigating Characteristics of Human Polyimaviruses Infection after Kidney Transplantation
E. Favi¹, S. Delbue², C. Colico¹, L. Signorini², L. Clementoni¹, M. Ferraresso¹
¹Renal Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, ²Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy
*Purpose: Human Polyomaviruses (HPyV) infections are extremely common, ranging from 60% to 100% in the general population, depending on the virus. After primary infection, which…
2020 American Transplant Congress
Anticipated Observations: The Role of DQ Antigen Frequencies among Donors and Recipients in a Pediatric Renal Transplant Cohort
S. Gattis¹, R. George², R. Liverman³, A. Serluco³, R. Garro², J. Figueroa², R. A. Bray², H. M. Gebel², H. C. Sullivan²
¹Emory Healthcare, Atlanta, GA, ²Emory University School of Medicine, Atlanta, GA, ³Children's Healthcare of Atlanta, Atlanta, GA
*Purpose: Donor specific HLA antibodies (DSA) that develop in the face of donor-recipient HLA mismatches are well-established independent predictors of graft loss in solid organ…
2020 American Transplant Congress
Complement Activation and Delayed Graft Function after Kidney Transplantation
C. Arias-Cabrales¹, M. Pérez-Sáez¹, M. Riera¹, J. Gimeno², D. Benito¹, D. Redondo-Pachón¹, A. Buxeda¹, C. Burballa¹, M. Crespo¹, J. Pascual¹, E. Rodríguez¹
¹Nephrology, Hospital Del Mar, Barcelona, Spain, ²Pathology, Hospital Del Mar, Barcelona, Spain
*Purpose: Ischemia-reperfusion (I/R) damage is the most important cause of delayed graft function (DGF), which has a negative impact on kidney transplant (KT) outcomes. Complement…