Articles tagged "Kidney transplantation"

2020 American Transplant Congress
Anti-HLA IgM Antibodies are Unaffected by Imlifidase (IdeS) Treatment
A. Runström¹, R. Bockermann¹, K. Sjöholm¹, K. M. Roupé¹, Å. Schiött¹, L. Winstedt¹, C. Kjellman¹, T. Lorant²
¹Hansa Biopharma AB, Lund, Sweden, ²Section of Transplantation Surgery, Department of Surgical Sciences, Uppsala, Sweden
*Purpose: The immunoglobulin G (IgG)-degrading cysteine protease, imlifidase (IdeS) is an IgG endopeptidase under development as a rapid desensitization treatment in kidney transplantation. Imlifidase is…
2020 American Transplant Congress
Clinicopathological Evaluation of Long-Term Survivor More Than 10 Years after Living Kidney Transplant with Corticosteroid Early Withdrawal Protocol
H. Sasaki¹, T. Tanabe¹, H. Higuchi¹, T. Tsujimoto², H. Harada¹
¹Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Japan, ²Pharmacy, Sapporo City General Hospital, Sapporo, Japan
*Purpose: We have previously reported that favorable short-term outcomes of kidney recipients were achieved by corticosteroid early withdrawal protocol (CSEW) compared to the conventional protocol…
2020 American Transplant Congress
Paired-Donor Kidney Exchange Has Comparable Early Graft Function to Directed Living Donor
E. McCracken, A. Sites, B. Rawashdeh, A. Nishio-Lucar, A. Agarwal
Transplant Surgery, University of Virginia, Charlottesville, VA
*Purpose: Living kidney donation in the United States is associated with improved graft and patient survival. However, there is minimal data on graft function in…
2020 American Transplant Congress
Hepatitis C-Infected Donors and Hepatitis C-Infected Recipients: Analysis of Renal Transplant Outcomes
H. Crossman¹, M. Tavakol², C. Freise², P. Chin-Hong³
¹Internal Medicine Residency Program, UCSF, San Francisco, CA, ²Surgery, UCSF, San Francisco, CA, ³Infectious Disease, UCSF, San Francisco, CA
*Purpose: Increased utilization of hepatitis C virus infected organs could reduce the supply demand mismatch in organ transplantation. At this time, there is little data…
2020 American Transplant Congress
Efficacy and Safety of Single-Dose Rabbit Anti-Thymocyte Globulin versus Basiliximab Induction among Pediatric Kidney Transplant Recipients
L. Porini Custodio, S. Stopa Martins, L. Almeida Viana, M. Pontello Cristelli, M. Rika Nakamura, H. Tedesco-Silva, J. Medina-Pestana
Hospital do Rim, Sao Paulo, Brazil
*Purpose: Induction therapy is a standard component of kidney transplant immunosuppression protocols. However, in the pediatric population, there are still uncertainties about the ideal induction…
2020 American Transplant Congress
Analyzing the Effect of a Closed Incision Negative Pressure Wound Therapy System on Wound Complications and Surgical Site Infections in Kidney Transplant Recipients: A Propensity Score Matched Analysis
S. Lam, A. Huynh, J. M. Laurence
Transplantation Services, Royal Prince Alfred Hospital, Sydney, Australia
*Purpose: The purpose of this study is to determine if a closed incision negative pressure wound therapy (ciNPWT) system prevents wound complications and surgical site…
2020 American Transplant Congress
The Noninvasive Urinary Sediment Double Immunostaining Test Predicts BK Polyomavirus Nephropathy in Kidney Transplant Recipients
G. Huang¹, X. Chen¹, S. Yang¹, X. Hou², H. Yang³, C. Wang¹
¹The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Guangzhou KingMed Center for Clinical Laboratory Co, Ltd, Guangzhou, China, ³Fuda Cancer Hospital, Jinan University, Fuda Cancer Hospital, Guangzhou, China
*Purpose: This study aimed to improve the diagnostic value of decoy cells for BK polyomavirus associated-nephropathy (BKPyVAN) in kidney transplant recipients.*Methods: A total of 105…
2020 American Transplant Congress
Is the Epitope Mismatch Load Enough to Identify HLA-DQ Mismatches with a Low Risk for De Novo DSA Development?
V. Jucaud¹, M. Stegall², C. Schinstock², R. Heilman³, L. Rebellato⁴, M. Samaniego-Picota⁵, D. Leeser⁴, M. Gandhi², J. Beaumont¹, M. Everly¹
¹Terasaki Research Institute, Los Angeles, CA, ²Mayo Clinic, Rochester, MN, ³Mayo Clinic, Phoenix, AZ, ⁴East Carolina University, Greenville, NC, ⁵Henry Ford Transplant Institute, Detroit, MI
*Purpose: The development of de novo donor-specific anti-HLA antibodies (dnDSA) remains a major risk factor for poor long-term kidney allograft outcomes. In particular, anti-HLA-DQ dnDSAs,…
2020 American Transplant Congress
A Two-Step Cell-Based Assay Predicts Immunosuppression-Related Adverse Events in Kidney Transplant Recipients
F. Bouchard-Boivin, O. Désy, S. Béland, S. De Serres
Transplantation Unit, Renal Division, Medecine Department, Laval University, Québec, QC, Canada
*Purpose: No clinical tool is available to dynamically access immunosuppression status, which results in serious, often life-threatening adverse effects of immunosuppressants. We recently validated that…
2020 American Transplant Congress
Human Organ Culture: A Novel Method for Evaluation of Reperfusion Injury in Human Kidney
J. T. Langford¹, C. Edwards¹, J. DiRito², M. Harris¹, S. A. Hosgood³, M. L. Nicholson³, J. S. Pober⁴, D. Haakinson¹, G. T. Tietjen¹
¹Department of Surgery, Yale School of Medicine, New Haven, CT, ²Department of Biomedical Engineering, Yale University, New Haven, CT, ³Department of Surgery, University of Cambridge, Cambridge, United Kingdom, ⁴Department of Immunobiology, Yale School of Medicine, New Haven, CT
*Purpose: Evaluate the ability of human organ culture to assess protein secretion during a model of reperfusion injury.*Methods: Biopsies are obtained from transplanted-declined human kidneys…