Articles tagged "Kidney transplantation"

2021 American Transplant Congress
Worsening Impact of Acute Kidney Rejection on Long Term Graft Survival from 2000 to 2014
D. Leeser¹, W. Irish¹, K. Ravindra², V. Villani², A. Connor², J. Tuttle¹
¹Surgery, East Carolina University, Greenville, NC, ²Surgery, Duke University, Durham, NC
*Purpose: Acute rejection (AR) has been shown to impact graft survival after kidney transplant (KTx), however there is limited data on its impact on long…
2021 American Transplant Congress
The Role of Donor-derived Cell-free DNA to Detect Subclinical Acute Rejection in Kidney Allograft
S. Park¹, K. Guo², R. Heilman³, E. Poggio⁴, D. Taber⁵, C. Marsh⁶, S. Kurian⁷, S. Kleiboeker⁸, J. Weems⁹, J. Holman¹⁰, L. Zhao², R. Sinha⁸, S. Brietigam², C. Rebello², M. Abecassis¹¹, J. Friedewald¹
¹Transplant nephrology, Northwestern University, Chicago, IL, ²Feinberg School of Medicine, Northwestern University, Chicago, IL, ³Transplant nephrology, Mayo Clinic College of Medicine and Science, Phoenix, AZ, ⁴Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH, ⁵Division of Transplant Surgery, Medical University of South Carolina, Charleston, SC, ⁶Department of Medicine and Surgery, Scripps Clinic and Green Hospital, La Jolla, CA, ⁷Scripps Health, La Jolla, CA, ⁸Eurofins US Clinical Diagnostics, Lee's Summit, MO, ⁹Eurofins US Clinical Diagnostics, Lee’s Summit, MO, ¹⁰Transplant Genomics, Inc, Mansfield, MA, ¹¹University of Arizona College of Medicine, Northwestern University, Tucson, AZ
*Purpose: We hypothesized that donor-derived cell-free DNA (dd-cfDNA) could detect subclinical acute rejection (subAR).*Methods: 429 blood samples paired with surveillance kidney biopsies from 208 patients…
2021 American Transplant Congress
Single-Dose Basiliximab Induction Therapy in Low-Immunologic Risk Kidney Transplant Recipients
A. Hutchins, J. Schoen, J. S. McMullen
Pharmacy, Nebraska Medicine, Omaha, NE
*Purpose: The purpose of this study is to examine the outcomes associated with single-dose basiliximab in low-immunologic risk kidney transplant recipients following a revision to…
2021 American Transplant Congress
Beyond Microarrays: Insights from Ncounter Transcript Analysis of Routine Archival Kidney Allograft Biopsies
I. Rosales, K. Tomaszewski, A. Milagros, T. Kawai, R. Smith, R. Colvin
Massachusetts General Hospital, Boston, MA
*Purpose: Microarray mRNA analysis of renal allograft biopsies has discovered important insights, but has limitations as a practical clinical test. Here we evaluate a new…
2021 American Transplant Congress
Association of Donor Hepatitis C Virus Infection Status and Risk of Bk Polyomavirus Viremia After Kidney Transplantation
V. S. Potluri¹, D. E. Schaubel¹, M. E. Sise², B. P. Concepcion³, R. C. Forbes¹, E. A. Blumberg¹, D. Goldberg⁴, P. P. Reese¹, R. Bloom¹, D. Shaffer³, R. Chung², D. Sawinski¹, I. Strohben², N. Elias², A. Azhar⁵, M. Shah¹, J. Eason⁵, L. A. Binari³, M. Talwar⁵, V. Balaraman⁵, A. Bhalla⁵, B. Besharatian¹, M. Z. Molnar⁵
¹University of Pennsylvania, Philadelphia, PA, ²Massachusetts General Hospital, Boston, MA, ³Vanderbilt University Medical Center, Nashville, TN, ⁴University of Miami Miller School of Medicine, Miami, FL, ⁵Methodist University Hospital, Memphis, TN
*Purpose: Transplantation of kidneys from deceased donors with hepatitis C virus (HCV) infection into HCV-negative recipients has become more common, but some studies have suggested…
2021 American Transplant Congress
Recipient and Kidney Allograft Outcomes from Hypertensive Live-Donor in the United States
S. Riad¹, S. Jackson², D. Vock³, A. Matas⁴
¹Medicine, University of Minnesota, Minneapolis, MN, ²Complex Care Analytics, M-Health Fairview, Minneapolis, MN, ³School of Public Health, University of Minnesota, Minneapolis, MN, ⁴Surgery, University of Minnesota, Minneapolis, MN
*Purpose: Controlled hypertension in select prospective kidney donors is no longer an exclusion criterion for donation. We examined the association between pre-donation hypertension (HTN) and…
2021 American Transplant Congress
Re-Transplantation of Mouse Kidney Grafts to Study Local Immune Responses
D. Zhao, M. Oberbarnscheidt, F. Lakkis, K. Khodor
Starzl Transplantation Institution, Pittsburgh, PA
*Purpose: Mouse kidney transplantation has been widely used to study the immune response to allogeneic grafts. This response includes a circulating systemic compartment and a…
2021 American Transplant Congress
Characterization of Kidney Small Extracellular Vesicles Released During Normothermic Machine Perfusion
W. W. Woud¹, A. Arykbaeva², D. de Vries², I. Alwayn², K. Boer¹, C. Baan¹, M. Hoogduijn¹, R. Minnee³
¹Internal Medicine, Nephorology and Transplantation, Erasmus MC, Rotterdam, Netherlands, ²Department of Surgery, LUMC, Leiden, Netherlands, ³Department of Surgery, Division of Hepato-Pancreato-Biliary and Transplant Surgery, Erasmus MC, Rotterdam, Netherlands
*Purpose: By characterizing and quantifying the dynamical release of kidney Extracellular Vesicles (EVs) during Normothermic Machine Perfusion (NMP), we aim to gain a better understanding…
2021 American Transplant Congress
Continuation of Immunosuppression After the First Renal Allograft Failure Impacts Panel Reactive Antibody Status During Subsequent Renal Transplantation
J. Patel¹, S. Ali², M. L. Sanders³, C. P. Thomas³, D. Axelrod³, M. Bilal⁴, E. H. Field⁴, S. Kuppachi³
¹University of Iowa Hospitals & Clinics, Iowa CIty, IA, ²Louis A. Johnson VA Medical Center, Clarksburg, WV, ³University of Iowa Hospitals & Clinics, Iowa City, IA, ⁴Iowa City VA Health Care System, Iowa City, IA
*Purpose: The standard of care following renal allograft failure is to discontinue immunosuppression (IS) to limit risks from further IS. We hypothesized that continuation of…
2021 American Transplant Congress
AlloMap Kidney Gene Expression Profiling Discriminates Rejection from Immuno-Quiescence in Renal Transplant Recipients
E. Akalin¹, A. Djamali², H. Xu³, X. Jin³, R. N. Woodward³, S. Dholakia³, J. S. Bromberg⁴
¹Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, ²University of Wisconsin, Madison, WI, ³CareDx, Brisbane, CA, ⁴University of Maryland School of Medicine, Baltimore, MD
*Purpose: Assessment of immune activation is important when considering pathologies such as allograft rejection as well as potential interventions that may extend allograft survival. Optimizing…