Articles tagged "Kidney transplantation"

2021 American Transplant Congress
Kidney Transplantation from Marginal Donors: An Increased Risk of Urinary Complication. Study from 10279 Patients
B. Mesnard¹, M. Leroy², J. Hunter³, D. Kervella¹, M. Timsit⁴, L. Badet⁵, P. Glemain¹, E. Morelon⁵, F. Buron⁵, M. Le Quintrec-Donnette⁶, V. Pernin⁶, M. Ladriere⁷, S. Girerd⁷, C. Legendre⁴, A. Sicard⁸, L. Albano⁸, S. De Vergie¹, C. Kerleau¹, T. Prudhomme⁹, J. Rigaud¹, D. Cantarovich¹, G. Blanchot¹, G. Karam¹, M. Giral¹, S. Ville¹, J. Branchereau¹
¹Department of Urology, Chu Nantes, Nantes Université, ITUN, Nantes, France, Nantes, France, ²Department of Urology, Chu Nantes, Nantes Université, France, Nantes, France, ³Department of Urology, Nuffield Department of Surgical Science ,Oxford, Oxford, United Kingdom, ⁴Service de transplantation rénale, Hôpital Necker AP-HP, Paris, France, ⁵Service de transplantation, néphrologie et immunologie clinique, Hôpital Edouard Herriot, Hospices de Lyon, Lyon, France, ⁶Service de néphrologie-soins intensifs-dialyse et transplantation, Hôpital Lapeyronie, Montpellier, France, ⁷Service de transplantation rénale, CHU Brabois, Nancy, France, ⁸Service de néphrologie, Hôpital Pasteur, Nice, France, ⁹Service urologie, andrologie et transplantation rénale, Hôpital Rangeuil, CHU de Toulouse, Toulouse, France
*Purpose: Due to the increasing need of kidneys suitable for transplantation, we have expanded the donor population to include marginal donors (Extended criteria donor, controlled…
2021 American Transplant Congress
Kidney Allograft Outcomes in Pediatric Patients Transitioned to Adult Care – A Single Center Study
S. Subramanyam, G. Agarwal, M. Seifert, V. Kumar, G. Towns, K. Wille, S. Ong
University of Alabama at Birmingham, Birmingham, AL
*Purpose: The transition of healthcare for young adults with kidney transplants from pediatric to adult care settings is an area of need, hitherto under-recognized in…
2021 American Transplant Congress
Psmp is Discriminative for Chronic Active Antibody-Mediated Rejection and Predicts Graft Risk After Kidney Transplantation
Y. Fu, P. Zhan
Tianjin First Central Hospital, Tianjin, China
*Purpose: Chronic active antibody-mediated rejection (c-aABMR) is an intermediate process in the development of chronic antibody-mediated rejection (c-ABMR), a key problem in the long-term failure…
2021 American Transplant Congress
An Early Look at the OPTN Kidney Paired Donation Pilot Program’s New Priority Points Policy
S. E. Booker¹, R. Leishman¹, D. E. Stewart¹, T. Sandholm², J. Dickerson³, M. Pavlakis⁴, V. Casingal⁵
¹United Network for Organ Sharing, Richmond, VA, ²Carnegie Mellon University, Pittsburgh, PA, ³University of Maryland, College Park, MD, ⁴Beth Israel Deaconess Medical Center, Boston, MA, ⁵Carolinas Medical Center, Charlotte, NC
*Purpose: The OPTN implemented new policy on 10/24/19 changing how Kidney Paired Donation Pilot Program (KPDPP) priority points are awarded. The policy is intended to…
2021 American Transplant Congress
Dialysis Staff-Reported Impact of the Early Covid-19 Pandemic on Kidney Transplant Referrals and Evaluations
A. Perez¹, S. Retzloff¹, T. Browne², A. Cruz³, S. Wright³, S. Pastan⁴, R. Patzer¹
¹Department of Surgery, Emory University School of Medicine, Atlanta, GA, ²College of Social Work, University of South Carolina, Columbia, SC, ³IPRO ESRD Network of the South Atlantic, Morrisville, NC, ⁴Department of Medicine, Emory University School of Medicine, Atlanta, GA
*Purpose: COVID-19 has drastically impacted healthcare systems since its declaration as a pandemic in March 2020. Evidence of this impact persists among solid organ transplant…
2021 American Transplant Congress
Characterization of SGLT2 Inhibitor Use After Abdominal Transplant
F. Hailemariam¹, S. Yeager², J. Schulte³, P. Singh¹, A. Yadav¹
¹Transplant Nephrology, Thomas Jefferson University Hospital, Philadelphia, PA, ²Abdominal Transplant Pharmacist, Thomas Jefferson University Hospital, Philadelphia, PA, ³Abdominal Transplant, Clinical Pharmacist, Thomas Jefferson University Hospital, Philadelphia, PA
*Purpose: Post solid organ transplantation, diabetic kidney disease (DKD) can progress due to recurrent pre-transplantation diabetes or the development of post-transplantation diabetes mellitus (PTDM). This…
2021 American Transplant Congress
Engineered Human Glomerular Endothelial Cells to Identify Non-hla Antibodies and Decipher Their Pathogenicity After Kidney Transplantation
B. Lamarthée¹, C. Burger¹, C. Leclaire¹, L. Morin¹, F. Terzi¹, C. Tinel¹, D. Anglicheau²
¹Inserm U1151, Necker-Enfants Malades Institute, PARIS, France, ²Necker Hospital, AP-HP, Department of Nephrology and Kidney Transplantation, PARIS, France
*Purpose: In kidney transplantation recipients (KTRs), donor-specific antibodies directed against Human Leucocyte Antigens (HLA-DSA) are thought to drive antibody-mediated rejection (AMR) and poor transplant outcome.…
2021 American Transplant Congress
The Impact of Covid-19 in Kidney Transplant Recipients: A Systematic Review and Meta-analysis
J. Kumar¹, J. Pyda², I. Reccia³, F. VIrdis⁴, P. Bachul¹, R. Barth¹, Y. Becker¹, J. Fung¹, P. Witkowski¹
¹University of Chicago, Chicago, IL, ²Beth Israel, Boston, MA, ³Imperial College, London, United Kingdom, ⁴Royal London, London, United Kingdom
*Purpose: To determine pooled prevalence of clinical outcomes among hospitalized kidney transplant recipients with COVID-19 through meta-analysis.*Methods: A systematic database search between Dec1, 2019- Dec1,…
2021 American Transplant Congress
Anti-CD8 Immuno-PET for Non-invasive Tracking of Early Graft Rejection in a Non-human Primate Kidney Transplant Model
K. Bruestle¹, R. Tavare², F. Fredriksson¹, E. Duggan¹, F. Huang¹, B. Bhola¹, J. Giurleo², R. Foster², P. Krueger², M. Dobosz², D. Ekanayake-Alper¹, H. Sakai¹, B. Piegari¹, J. Castrillion¹, S. M. Coley¹, O. Harari², A. Mintz¹, D. Ma², A. Griesemer¹
¹Columbia University Medical Center, New York City, NY, ²Regeneron Pharmaceuticals, Inc, New York City, NY
*Purpose: Infiltration of CD8 T cells into solid organ grafts is an early sign of rejection. REGN5054 is a fully human monoclonal antibody that binds…
2021 American Transplant Congress
Belatacept Pharmacokinetic Analysis Comparing Belatacept Early Steroid Withdrawal Trial (BEST) with Benefit and Benefit-ext Trials
A. Bickenbach¹, M. McGowan¹, B. Miyagawa², T. Mizuno², A. Shields³, A. Christianson¹, P. West-Thielke⁴, J. Leone⁵, E. Woodle¹, D. Kaufman⁶, A. Wiseman⁷, A. Matas⁸, A. Vinks²
¹U Cincinnati, Cincinnati, OH, ²Cincinnati Childrens Med Center, Cincinnati, OH, ³Christ Hospital, Cincinnati, OH, ⁴UIC, Chicago, IL, ⁵Tampa Gen, Tampa, FL, ⁶U Wisconsin, Madison, WI, ⁷Centura Transplant, Denver, CO, ⁸U Minnesota, Minneapolis, MN
*Purpose: Belatacept(BELA) pharmacokinetic(PK) studies informed dosing in phase 3 studies where fixed mg/kg dosing compared a less intense(LI) and more intense(MI) regimen. LI was preferred…