2021 American Transplant Congress
The Effect of Daratumumab (Dara, Humanized Anti-CD38 Monoclonal Antibody) on Immune Cells In Vitro and in a HLA-Sensitized Kidney Transplant Patient (HS KTx Pt) Desensitized (DES) with Dara
*Purpose: Antibody-Mediated Rejection (ABMR), primarily mediated by B cells, plasma cells (PC) and antibodies (Ab), is an obstacle for successful transplantation in HS KTx Pts.…2021 American Transplant Congress
Covid-19 Impact of the Pandemic Surge on Patients Waiting for Renal Transplantation at a Single New York City Transplant Center
Transplant, NYP - Columbia University Medical Center, New York, NY
*Purpose: There was a critical need to understand the impact that the COVID-19 pandemic had on our patients awaiting transplantation, including infection rates, morbidity, mortality,…2021 American Transplant Congress
Sequential Analysis of Renal Allograft Rejection at Single Cell Resolution
*Purpose: Renal allograft anti-rejection therapies (corticosteroids (CCS) and anti-lymphocyte globulin) have been the primary treatment modalities for over six decades, yet little is known about…2021 American Transplant Congress
Digital Spatial Mrna Profiling Reveals Distinct Endothelial Transcripts in Dsa+ and Dsa- Endarteritis in Kidney Allografts
*Purpose: Renal allograft biopsy transcript analysis is typically performed by microarray, which lacks spatial resolution. We initiated a systematic program using the NanoString GeoMx® Digital…2021 American Transplant Congress
Depressive Symptoms and Listing for Kidney Transplantation
Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Among patients with kidney failure, depressive symptoms are common and may be a barrier to completing the complex process of kidney transplantation (KT) evaluation…2021 American Transplant Congress
Economic Impact of a Pharmacist-Led Medication Safety Intervention: Report from the Transafe Rx Randomized Controlled Trial
Med Univ of South Carolina, Charleston, SC
*Purpose: We have previously demonstrated the efficacy of a pharmacist-led, mHealth intervention on reducing medication errors and adverse events leading to reduce hospitalizations in kidney…2021 American Transplant Congress
Single Day Centralized Approach in Kidney Transplant Workup – Lessons Learned from 2 Centers
Tulane Abdominal Transplant Institute, New Orleans, LA
*Purpose: Time from transplant evaluation to UNOS listing is unaccounted towards wait-list time in pre-dialysis patients and hence longer evaluation to listing times can prolong…2021 American Transplant Congress
Single Cell RNAq-seq Analysis of Paired Peripheral and Intragraft T Cells Reveals Biopsy Specific Fc Receptor Gene Expression in Rejection Only
Washington University School of Medicine, St Louis, MO
*Purpose: Antibody mediated rejection (AMR) remains one of the major causes of allograft failure and our understanding of this disease process is poor. Transcriptomics studies…2021 American Transplant Congress
Real-time Donor-derived Cell-free Dna Kinetics Indicate Decreased “Molecular Injury” During Treatment of Acute Renal Allograft Rejection
*Purpose: Dd-cfDNA is a validated plasma analyte (t½~30 min) for surveillance of renal transplant (KT) rejection with limited reports characterizing response to acute allograft rejection…2021 American Transplant Congress
Trugraf Gene Expression Testing Can Discriminate Rejection in the Setting of Acute Kidney Injury
*Purpose: The TruGraf kidney blood gene expression test is a well-validated non-invasive biomarker to detect immune quiescence thus ruling out silent subclinical rejection in stable…
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