Articles tagged "Kidney transplantation"

2021 American Transplant Congress
Nonadherence Post-kidney Transplant is Associated with Increased Immune Activation Detected by Peripheral Blood Gene Expression Assay
N. Singh¹, A. Palermini¹, M. S. Naseer¹, T. Le¹, S. Tandukar¹, D. Aultman², H. Shokouh-Amiri², G. Zibari²
¹Transplant, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA, ²Advanced Surgery, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA
*Purpose: Nonadherence to immunosuppression medications is common post-transplantation. We hypothesize that nonadherence results in a heightened alloimmune response in kidney transplant recipients (KTRs) which in…
2021 American Transplant Congress
Risk Factors and Outcomes of Neutropenia in Kidney Transplant Recipients
R. Avery¹, J. Motter¹, S. Sae-Tia², N. Lu¹, W. Cochran¹, A. Massie¹, D. Brennan¹, F. Akinwande¹, S. Shoham¹, E. Kraus¹, N. Alachkar¹, S. Alasfar¹, F. Naqvi¹, F. Al Ammary¹, K. Marr¹, S. Mehta Steinke¹, N. Desai¹, O. Ezennia¹, P. Plummer¹, C. Durand¹, W. Werbel¹, M. Y. Kim¹, D. Segev¹, J. Garonzik Wang¹, B. Trollinger¹, L. Lees¹, L. Toman¹, S. Shulder³, K. Dzintars¹, D. Ostrander¹
¹Johns Hopkins, Baltimore, MD, ²Stony Brook University, Stony Brook, NY, ³University of Rochester, Rochester, NY
*Purpose: Neutropenia is a common side effect of valganciclovir and may pose increased risk for post-transplant infections. Medications such as mycophenolate and infections such as…
2021 American Transplant Congress
Changes in Cytomegalovirus Specific T Cell Immunity With Immunomodulation in Serodiscordant High Risk Transplant Recipients
T. Tinkham, C. Song, R. Winstead, I. Yakubu, A. Brown, S. Sterling, G. Gupta, D. Kumar
Virginia Commonwealth University Health, Richmond, VA
*Purpose: Cytomegalovirus (CMV) infections cause significant morbidity and mortality among all solid organ transplant recipients. CMV discordant (D+/R-) recipients are at higher risk of developing…
2021 American Transplant Congress
Discontinuation of Trimethoprim/sulfamethoxazole Prophylaxis Due to Hyperkalemia in Kidney Transplant Recipients
D. Pett¹, G. Malat², C. Domenico¹, R. Samudralwar¹, A. Forte¹, D. Sawinski², J. Hu¹, B. Steiner¹, J. Rashid¹, J. Trofe-Clark²
¹Pharmacy, Hospital of Univ of Pennsylvania, Philadelphia, PA, ²Penn Transplant Institute, Hospital of Univ of Pennsylvania, Philadelphia, PA
*Purpose: Trimethoprim-sulfamethoxazole (TMP-SMX) is the drug of choice for Pneumocystis jirovecii pneumonia (PJP) prophylaxis in kidney transplant recipients (KTRs), however, it can be complicated by…
2021 American Transplant Congress
Exploring the Correlation with Donor Hepatitis C Viral Load and Viral Kinetics in Naïve Kidney Transplantation Recipients
A. Brooks¹, A. Rechnitzer¹, R. Teo¹, D. Y. Goldstein², M. Narlieva², J. P. Rocca¹, M. Ajaimy¹, L. Liriano-Ward¹, Y. Azzi¹, C. Pynadath¹, P. Loarte-Campos¹, E. Akalin¹, M. E. Le¹, H. Yaffe¹, S. Greenstein¹, J. Torabi¹, M. M. Kinkhabwala¹, J. A. Graham¹
¹Montefiore-Einstein Center for Transplantation, Montefiore Medical Center, Bronx, NY, ²Pathology, Montefiore Medical Center, Bronx, NY
*Purpose: The transplantation of Hepatitis C viremic (HCV) kidneys into uninfected recipients was made possible by effective direct acting anti-viral (DAA) therapy. This study aims…
2021 American Transplant Congress
The Extremes of KDPI: Even KDPI 95%+ Kidneys Can Be Used Successfully
A. Gilbert, J. Verbesey, B. Thomas, J. Moore, M. Cooper
Medstar Georgetown Transplant Institute, Washington, DC
*Purpose: While the use of kidneys with KDPIs greater than 85% has become common, there is still reluctance among centers to use the very highest…
2021 American Transplant Congress
Identifying Barriers to Transition Readiness in Pediatric Kidney Transplant Patients
K. Amatya, S. Yuhas-Schiltz, C. Petyak, A. Moudgil
Nephrology, Children's National Medical Center, Washington, DC
*Purpose: Inadequate readiness for transition from pediatric to adult care is associated with loss of transplant, initiation of or return to dialysis, and other negative…
2021 American Transplant Congress
Impact of Treatment of Subclinical Rejection at 2 Weeks After Kidney Transplantation, Compared by 1 Year Histologic Outcomes
O. Lee¹, K. Lee¹, J. Park¹, J. Lee², G. Kwon³, K. Kim⁴
¹Surgery, Samsung Medical Center, Seoul, Korea, Republic of, ²Medicine, Samsung Medical Center, Seoul, Korea, Republic of, ³Pathology, Samsung Medical Center, Seoul, Korea, Republic of, ⁴Biostatistics, Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: Subclinical rejection (SCR) is associated with chronic allograft nephropathy, which is the most common cause of allograft failure in kidney transplantation (KT). Therefore, early…
2021 American Transplant Congress
The Impact of Fixed-Dose Alemtuzumab in Renal Transplant Recipients According to Weight
S. Mandala¹, N. Khodieva², A. Bigness¹, S. Mohamed², H. Mohammed¹, K. Robichaux², A. Brueckner³, R. Baliga⁴, J. Buggs⁵, A. Kumar¹, L. Bowman³
¹Morsani College of Medicine, University of South Florida, Tampa, FL, ²Honors College, University of South Florida, Tampa, FL, ³Transplant Pharmacy, Tampa General Hospital, Tampa, FL, ⁴Nephrology, Florida Kidney Physicians, Tampa, FL, ⁵Transplant Surgery, Tampa General Hospital, Tampa, FL
*Purpose: Alemtuzumab, a potent anti-CD52 monoclonal antibody is used for induction immunosuppression post-renal transplantation as a fixed 30mg dose regardless of the patient’s weight. The…
2021 American Transplant Congress
Frailty Component Trajectories Among Kidney Transplant Recipients
N. Chu, X. Chen, D. Segev, M. McAdams-DeMarco
Johns Hopkins, Baltimore, MD
*Purpose: Frailty is associated with decreased access to kidney transplantation (KT) and poor post-KT outcomes. Little is known about how an acute stressor, like KT,…