2021 American Transplant Congress
Resolution of Endothelial Inflammation is Delayed Following IFNγ, Which Provokes a Long-lasting Pro-adhesive Phenotype Dependent on JAK/STAT Signaling
Pathology and Laboratory Medicine, UCLA, Los Angeles, CA
*Purpose: Although many cytokines are upregulated within allografts undergoing rejection, intragraft transcripts are dominated by IFN-response signatures. Resolution is a key phase of inflammation needed…2020 American Transplant Congress
Protection Role of microRNA let-7 in Hepatic Ischemia Reperfusion Injury by Inhibiting JAK-STAT3 Pathway
*Purpose: Ischemia reperfusion injury (IRI) is an inevitable event in conventional organ transplant procedure and affects the prognosis in post-transplantation. Increasing evidence suggests that microRNA…2020 American Transplant Congress
A Novel Injectable Hydrogel-Based Approach to Localize and Tune the Actuation of Enhanced Costimulation Blockade to the Strength of Transplant Rejection
*Purpose: Complications from long-term use of calcineurin inhibitors remain a major issue for transplant patients and alternative therapies are needed. The clinical efficacy of CTLA4-Ig…2019 American Transplant Congress
JAK Inhibitor as a Novel Conditioning Approach to Establish Mixed Chimerism and Prevent Type 1 Diabetes Nonmyeloablatively
*Purpose: Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of islet β cells. T1D has been found to be associated…2018 American Transplant Congress
Biomaterial-Based Localized and Controlled Delivery of Tofacitinib to Actuate Enhanced Costimulation Blockade and Promote Long-Term Transplant Survival
Complications from long-term use of calcineurin inhibitors remain a major issue for transplant patients and alternative therapies are highly needed. We investigated two innovative drug…2017 American Transplant Congress
Designing a Novel Selective Immunoproteasome Inhibitor Reveals a Critical Role of the IP and STAT5 Pathway in Regulating T Cell Exhaustion and Promoting Long Term Heart Allograft Acceptance.
Constitutive proteasomes (c-20S) are ubiquitously expressed cellular proteases that degrade polyubiquitinated proteins and regulate cell functions. Immunoproteasomes (IP or i-20S) are primarily expressed in immune…2017 American Transplant Congress
The Beneficial Effect of Janus Kinase 3 Inhibitor on Transplanted Islet via Protection from Oxidative Stress-Induced β Cell Death.
Janus kinase 3 (JAK3) is one of the molecules that make up the JAK-STAT signaling pathway that regulates numerous 40 cytokines. Thus, this cascade can…2017 American Transplant Congress
Tofacitinib-Loaded Solid Lipid Nanoparticles Inhibits Dendritic Cell Antigen Presenting Functions and Achieve Selective In Vivo Targeting.
BackgroundComplications from long-term use of calcineurin inhibitors are a major concern for transplant patients. To develop CNI-free therapies, we investigated an innovative drug delivery method…2017 American Transplant Congress
Activation of Inflammation Amplifier in Kidney Graft and Urinary Biomarker for Chronic Rejection.
[Introduction and Objective] Inflammation amplifier (IA), a local chemokine inducer in non-immune cells is induced by simultaneous activation of NFκB and STATs (IL-17, TNFα, and…2016 American Transplant Congress
Tofacitinib Delivered by Solid Lipid Nanoparticles Inhibits Dendritic Cell Maturation and Their Allostimulatory Capacity.
BackgroundComplications caused by long-term immunosuppression remain a major concern for transplant patients. To optimize controlled and accurate dosing, we investigated an innovative drug delivery method…
American Transplant Congress abstracts