Articles tagged "Interferon (IFN)"

2016 American Transplant Congress
IFN-γ and Contact-Dependent Cytotoxicity Are Rate-Limiting for NK Cells in a Model of Antibody-Mediated Chronic Rejection.
C. Lin,¹ R. Plenter,¹ R. Gill.²
¹Medicine, University of Colorado, Denver, Aurora, CO; ²Surgery, University of Colorado, Denver, Aurora, CO.
BACKGROUND. Natural killer (NK) cells are key components of the innate immune that contribute to acute and chronic graft rejection. After engagement with antibody, NK…
2016 American Transplant Congress
Polyfunctionality of CD8 T Cell Responses to Cytomegalovirus in Transplant Patients.
L. Higdon,¹ K. Margulies,² J. Maltzman.^1,3
¹Stanford University, Palo Alto; ²University of Pennsylvania, Philadelphia; ³Veterans Administration Medical Center, Palo Alto.
Background: Cytomegalovirus (CMV) infection causes significant morbidity including allograft damage in transplant patients. Primary infection with CMV is rapidly resolved in healthy individuals; memory T…
2015 American Transplant Congress
Effective Control of Anti-Xenogeneic IL-17 Response for Tolerance Induction in Xenogeneic Islet Cell Transplantation
H. Kang,¹ S. Wang,^1,2 X. Zhang,³ L. Zhang,¹ S. Miller,⁴ B. Hering,⁵ X. Luo.^1,3,4
¹Medicine, Northwestern University Feinberg school of Medicine, Chicago, IL; ²Tianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, China; ³Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL; ⁴Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL; ⁵Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN.
We have previously shown that peri-transplant infusion of donor cells treated with 1-ethyl-3-(3'-dimethylaminopropyl)-carbodiimide (ECDI) in combination with peri-transplant anti-CD20 and rapamycin induce permanent porcine islet…
2015 American Transplant Congress
PI3Kα and STAT1 Interplay Regulates Human Mesenchymal Stem Cell Immune Polarization
E. Kefalogianni,¹ M. Mounayar,² B. Smith,² J. Azzi,² L. Chabtini,² P. Fiorina,² M. Kraus,³ R. Briddell,⁴ W. Fodor,⁵ A. Herrlich,¹ R. Abdi.²
¹Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ²Transplantation Research Center, Brigham and Women's and Children's Hospital, Harvard Medical School, Boston, MA; ³Viacord LLC, a PerkinElmer Company, Cambridge, MA; ⁴ViaCord Processing Lab, Viacord LLC, a PerkinElmer Company, Hebron, KY; ⁵The Cell Therapy Group, Madison, CT.
The immunomodulatory capacity of mesenchymal stem cells (MSC) is critical for their use in therapeutic applications. MSC response to specific inflammatory cues allows them to…
2015 American Transplant Congress
Targeted Rapamycin Nanotherapy Dampens Memory T Cell Function
S. Nadig,¹ S. Esckilsen,¹ A.-M. Broome,² S. Dixit,² C. Atkinson.³
¹Surgery, Microbiology and Immunology, Medical University of South Carolina, Charleston, SC; ²Radiologic Sciences, Medical University of South Carolina, Charleston, SC; ³Microbiology and Immunology, Medical University of South Carolina, Charleston, SC.
Memory T cells (Tm) are difficult to control post-transplantation and account for early rejection episodes. Additionally, therapies exerting local immunosuppression by targeting an allograft, while…
2015 American Transplant Congress
Assessing Pre-Vaccination Cytokine Levels to Predict Immunogenicity to Seasonal Trivalent Influenza Vaccine in Solid Organ Transplant Recipients
M. Fernandez-Ruiz, A. Humar, S. Keshwani, S. Husain, D. Kumar.
Multi-Organ Transplant Program, University Health Network, Toronto, Canada.
Background: The immunogenicity of seasonal trivalent influenza vaccine (TIV) in solid organ transplant (SOT) recipients remains suboptimal. We hypothesized that analysis of pre-vaccination T- and…
2015 American Transplant Congress
Evaluation of Natural Killer Cell Activation by NK Cell-Specific Interferon-Gamma-Releasing Assay
J. Ryu,¹ K. Park,¹ Y. Kim,² E.-J. Oh.²
¹Department of Biomedical Science, Graduate School, The Catholic University of Korea, Seoul, Republic of Korea; ²Laboratory Medicine, Seoul St. Mary's Hospital, the Catholic University of Korea, Seoul, Republic of Korea.
Introduction: Although NK cell activity (NKA) has a variety of measuring markers including chromiun release assay and flowcytometry-based cytolysis, limitations such as radioactivity and lack…
2015 American Transplant Congress
IFNγ Is Required for nTreg Afferent Lymphatic Migration
S. Ahmad, Y. Xiong, C. Brinkman, J. Bromberg.
Surgery, University of Maryland, Baltimore, MD.
Background: Natural Treg (nTreg) must migrate from graft to draining lymph node (LN) to prolong islet allograft survival, and we previously showed that the transcription…