ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Integrins"

  • 2021 American Transplant Congress

    Antibodies to Hla Molecules Lead to Induction and Release of Circulating Exosomes with Lung Self-Antigens

    R. Ravichandran, M. Smith, R. Bremner, T. Mohanakumar

    St. Joseph’s Hospital and Medical Center, Phoenix, AZ

    *Purpose: Antibodies (Abs) to human leukocyte antigen (HLA) (anti-HLA) can injure allograft by complement-dependent/independent mechanisms. Crosslinking of HLA-class I with Abs associate with integrin β4…
  • 2019 American Transplant Congress

    Laminin Dependent T Cell Migration Determines Allograft Survival

    L. Li, M. Shirkey, W. Piao, Y. Xiong, V. Saxena, T. Zhang, B. M. Cerel, C. Paluskievicz, J. S. Bromberg

    Surgery, U. Maryland, Baltimore, Baltimore, MD

    *Purpose: Differential expression of lymph node (LN) stromal laminins α5β1γ1 (511) and α4β1γ1 (411) is associated with tolerance and immunity, respectively. We investigated the hypothesis…
  • 2018 American Transplant Congress

    VLA-4 Blockade Inhibits Early Endogenous Memory CD8 T Cell Infiltration into Higher Risk Cardiac Allografts and Donor-Reactive T Cell Priming

    S. Miyairi,1 S. Iida,2 H. Tsuda,1 W. Baldwin III,1 K. Tanabe,2 R. Fairchild.1

    1Immunology, Cleveland Clinic, Cleveland, OH; 2Urology, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan.

    Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts within 24 hrs after graft reperfusion in mice. Our recent studies indicate that prolonged cold ischemic…
  • 2017 American Transplant Congress

    Lymph Node Stromal Laminins Differentially Regulate T Cell Activation.

    T. Simon, J. Bromberg.

    University of Maryland, Baltimore

    Background:Our recent work demonstrated that laminins α4β1γ1 and α5β1γ1, components of the lymph node (LN) stroma, are differentially regulated. Tolerance is associated with relatively higher…
  • 2017 American Transplant Congress

    The Treg/Th17 Axis: A Dynamic Balance Regulated by Stromal Laminins.

    T. Simon, J. Bromberg.

    University of Maryland, Baltimore

    Background: Our recent work demonstrated that laminins α4β1γ1 and α5β1γ1, components of the lymph node (LN) stroma, are differentially regulated. Tolerance is associated with relatively…
  • 2015 American Transplant Congress

    Targeting Leukocyte Integrin CD11b/CD18 With a Novel mAb Salvages Renal Function Following an Otherwise Irreversible Ischemic Insult in Cynomolgus Monkeys

    A. Cosimi,1 A. Dehnadi,1 R. Smith,2 D. Ko,1 X. Li,3 M. Arnaout.3

    1Transplant Surgery, Massachusetts General Hospital, Boston, MA; 2Pathology, MGH, Boston, MA; 3Nephrology, MGH, Boston, MA.

    Allograft dysfunction resulting from ischemic reperfusion injury (IRI) leads to increased peri-transplant costs, morbidity, and inferior long-term survival. Leukocyte/endothelial adhesion is an important pathway contributing…

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