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Articles tagged "Insulin"

  • 2015 American Transplant Congress

    Is BMI of 28 an Appropriate Cutoff for Simultaneous Pancreas Kidney Transplant in Type II Diabetes?

    E. Ahmed, D. Bruce, I. Carmody, A. Cohen, G. Loss, T. Reichman, J. Seal, H. Bohorquez.

    Multi-Organ Transplant Institute, Ochsner Clinic Foundation, New Orleans, LA.

    In simultaneous pancreas and kidney (SPK) transplantation, obesity has been reported to be associated with inferior survival and increased post-transplant complications. With implementation of the…
  • 2015 American Transplant Congress

    Pancreas After Failed Islet Transplantation; a Successful Strategy to Maintain Insulin Independence

    J. Gardner,1 G. Roll,1 S. Wisel,1 J. Harbell,1 B. Hynson,1 D. Kaufman,2 A. Posselt,1 P. Stock.1

    1Department of Surgery, University of California, San Francisco, San Francisco, CA; 2Department of Surgery, University of Wisconsin, Madison, WI.

    Introduction: As islet transplantation (tx) remains an experimental and uninsured procedure, there are no established protocols to achieve insulin independence following failure of the islet…
  • 2015 American Transplant Congress

    Human iPS Cell-Derived Pancreatic β-Cells Correct Hyperglycemia in Diabetic Mice

    G. Manzar,1,2,3 E.-M. Kim,1,2 P. Rotti,3 N. Zavazava.1,2,3

    1Internal Medicine, University of Iowa, Iowa City, IA; 2VA Medical Center, Iowa City, IA; 3Biomedical Engineering, University of Iowa, Iowa City, IA.

    Type I diabetes (T1D) is an autoimmune disorder that leads to the destruction of pancreatic β-cells. The consequences of T1D are dysregulation of metabolism leading…
  • 2015 American Transplant Congress

    Pancreatic Islet Survival Under Confinement

    A. Rodriguez, S. Sigrist, E. Maillard.

    UMR DIATHEC EA 7294, Centre Européen d'Etude du Diabète, Strasbourg, France.

    The main advantage of cell therapy is the possibility to immune-isolate the graft in a device to avoid immune suppressive regimen. In islet transplantation field,…
  • 2015 American Transplant Congress

    Establishment of Diabetes Modeling in Common Marmoset

    W. Yuan,1 S. Fukuda,1 T. Inoue,2 D. Chujo,1 H. Okochi,1 E. Sasaki,2 M. Shimoda.1

    1National Center for Global Health and Medicine, Tokyo, Japan; 2Central Institute for Experimental Animals, Kawasaki, Japan.

    Background:Diabetic nonhuman primates (NHPs) are considered as the good models for both diabetes mellitus research and islet transplantation research safely into clinical applications. However, there…
  • 2015 American Transplant Congress

    Effect of Living Kidney Donation on Glucose Metabolism and Insulin Resistance

    B. Tanriover,1 P. Mohan,2 S. Cremers,3 I. Lingvay.4

    1Medicine/Nephrology, UT Southwestern, Dallas, TX; 2Medicine/Nephrology, Medical University of South Carolina, Charleston, SC; 3Biomarkers Core Laboratory, Columbia University, New York, NY; 4Medicine/Endocrinology, UT Southwestern, Dallas, TX.

    The kidney contributes to glucose hemostasis through processes of insulin metabolism, gluconeogenesis, and glucose filtration. Little is known on insulin sensitivity in living kidney donors…
  • 2015 American Transplant Congress

    Long-Term Metabolic Outcomes of Functioning Pancreas Transplants in Type 2 Diabetic Recipients

    S. Shin, Y. Kim, B. Choi, J. Choi, J. Jung, H. Cho, D. Han.

    Asan Medical Center, Seoul, Korea.

    Background Limited data are available on long-term metabolic outcomes of functioning pancreas transplants in patients with type 2 diabetes mellitus (T2DM). The aim of this…
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