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Articles tagged "Insulin"

  • 2019 American Transplant Congress

    microRNA-375 Provides an Objective Measure of Pancreas Quality in Organ Donors

    I. Shapey1, A. Summers1, J. O'Sullivan1, P. Yiannoullou1, J. Casey2, S. Forbes2, M. Rosenthal3, P. Johnson4, P. Choudhary1, J. Bushnell5, J. Shaw6, N. Hanley1, T. Augustine1, M. Rutter1, D. van Dellen1

    1University of Manchester, Manchester, United Kingdom, 2University of Edinburgh, Edinburgh, United Kingdom, 3Royal Free Hospital, London, United Kingdom, 4University of Oxford, Oxford, United Kingdom, 5Southmead Hospital, Bristol, United Kingdom, 6University of Newcastle, Newcastle, United Kingdom

    *Purpose: Donor pancreatic beta cells are at high risk from apoptosis. Objective methods for assessing the quality of donor pancreases for transplantation are limited. We…
  • 2019 American Transplant Congress

    Assessment of Culture/Preservation Conditions on Survival and Function of Islets

    Y. Shindo, M. F. Levy, M. A. Kanak

    Surgery, Virginia Commonwealth University, Richmond, VA

    *Purpose: Culture or preservation of human islets prior to transplantation has been adopted by various centers because it may reduce immunogenicity, suppress exocrine contamination and…
  • 2018 American Transplant Congress

    Prevention of New Onset Diabetes after Transplantation Using Bariatric Surgery

    A. Bailey, Y. Kim, S. Woodle, S. Shah, F. Paterno, M. Cuffy, T. Diwan.

    Transplant Surgery, University of Cincinnati, Cincinnati, OH.

    New onset diabetes after transplantation (NODAT) is a common complication, occurring 20-36% after renal transplant historically and 15.8% at our institution. Obesity is a known…
  • 2018 American Transplant Congress

    A Novel Approach to Preserve Pancreatic Islet Grafts in Extrahepatic Space for Reversal of Diabetes Using Parathyroid Gland Co-Transplantation

    C. Ward, G. Faleo, G. Nair, Q. Duh, M. Hebrok, W. Chang, P. Stock, Q. Tang.

    UCSF, San Francisco, CA.

    Intro: Islet transplantation can cure type 1 diabetes; however, multiple donors are needed due to extensive perioperative loss of islets away from their native blood…
  • 2018 American Transplant Congress

    SGLT2 Inhibition in Kidney Transplant Recipients with Diabetes

    M. Guthoff,1 M. Mahling,1 S. Nadalin,2 N. Heyne.1

    1Dept. of Endocrinology and Diabetology, Angiology, Nephrology and Clinical Chemistry, University of Tübingen, Tübingen, Germany; 2Dept. of General, Visceral and Transplant Surgery, University of Tübingen, Tübingen, Germany.

    Purpose: Sodium-glucose cotransporter 2 (SGLT2) inhibition has been shown to reduce cardiovascular mortality and preserve kidney function in patients with type 2 diabetes. Kidney transplant…
  • 2018 American Transplant Congress

    Peri-Transplant Glycaemic Control as a Predictor of Pancreas Transplant Survival

    M. Shapey,1,2 R. Tan,1 H. Khambalia,2 C. Fullwood,2 P. Yianoullou,1,2 A. Summers,2 T. Augustine,2 M. Rutter,1 D. van Dellen.2

    1Division of Diabetes, Endocrinology and Gastroenterology, University of Manchester, Manchester, United Kingdom; 2Department of Renal and Pancreatic Transplantaion, Manchester University NHS Foundation Trust, Manchester, United Kingdom.

    Introduction: The impact of peri-transplant glycaemic control on outcomes after pancreas transplantation is unknown. Our aims were to relate peri-transplant glycaemic control to survival and…
  • 2018 American Transplant Congress

    Comparison of Glycemic Control in Type 1 and Type 2 Diabetic Patients after Pancreas Transplantation

    O. Andacoglu,1 A. Murthy,2 J. Ahn,3 J. Verbesey,1 S. Ghasemian,1 M. Cooper,1 P. Abrams.1

    1Transplant, Medstar Georgetown Transplant Institute, Washington, DC; 2School of Medicine, Georgetown University, Washington, DC; 3Biopstatistics, Georgetown University, Washington, DC.

    Background: Pancreas transplant remains controversial for type 2 diabetic (T2DM) patients.Aim: To compare glycemic control following pancreas transplantation between T1 and T2 DM patients.Methods: 52…
  • 2018 American Transplant Congress

    BETA-2 Score is an Excellent Tool for Monitoring of Islet Allograft Function and Early Detection of Transplant Dysfunction

    P. Bachul,1 J. Gołębiewska,2 L. Basto,1 M. Kijek,1 N. Fillman,1 K. Cieply,1 K. Golab,1 L-.J. Wang,1 M. Tibudan,1 C. Thomas,1 A. Dębska-Ślizień,2 J. Fung,1 P. Witkowski.1

    1Surgery, University of Chicago, Chicago; 2Nephrology, Medical University of Gdańsk, Gdańsk, Poland.

    After validation of BETA-2 scores in our cohort of patients in relation to standard stimulation tests, we decided to assess the practical utility of BETA-2…
  • 2018 American Transplant Congress

    Insulin Use after Pancreas Transplant: Implications for Post-Transplant Outcomes

    R. Ouseph, K. Lentine,1 Z. Zhang,1 D. Axelrod,2 H. Randall,1 B. Kasiske,3 A. Israni,3 V. Dharnidharka,4 T. Alhamad,4 D. Brennan,5 D. Segev,5 G. Hess,6 M. Schnitzler.1

    1Saint Louis Univ, St. Louis; 2Lahey Clinic, Burlington; 3Hennepin County Med Center, Minneapolis; 4Washington Univ, St. Louis; 5Johns Hopkins, Baltimore; 6Symphony Health, Conshohocken.

    We examined associations of insulin use after pancreas transplant with patient survival, and with kidney graft survival among simultaneous kidney-pancreas transplant (SKPT) recipients, in a…
  • 2017 American Transplant Congress

    10 Years or More of Follow Up After Total Pancreatectomy and Intra Portal Islet Auto Transplantation (TP/IAT) for Treatment of Chronic Pancreatitis, Is It a Durable Operation?

    S. Chinnakotla, T. Dunn, G. Beilman, M. Bellin, T. Pruett, V. Kirchner, J. Wilhelm, M. Freeman, D. Sutherland.

    Surgery, University of Minnesota, Minneapolis

    Background: Total pancreatectomy and intra-portal islet cell auto-transplantation (TP/IAT) is increasingly being utilized for the management of chronic pancreatitis (CP), the benefits being removal of…
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