Articles tagged "Insulin"

2021 American Transplant Congress
Lacripep^TM-like Peptide N-104 Increases Insulin Secretion and Promotes Islet Transplantation Outcomes
M. Ma, P. Chhabra, K. Dias Teixeira, G. Laurie, K. Brayman
University of Virginia Health System, Charlottesville, VA
*Purpose: To study if LacripepTM-like peptide N-104 promotes beta-cell stabilization and islet transplantation outcomes. Background: Lacritin is a multifunctional tear protein with prosecretory, prosurvival and…
2021 American Transplant Congress
Effect of Insulin versus Oral Agents on Early Glycemic Control Following Kidney Transplant
A. Petrosan, A. Santeusanio, R. Khaim, V. Delaney
Mount Sinai Hospital, New York, NY
*Purpose: Insulin therapy is commonly prescribed to treat hyperglycemia early post-kidney transplant (KTx) due to its widespread availability and ease of titration. Alternatively, there is…
2021 American Transplant Congress
Impact of Insulin Therapy in Pancreas Transplantation Donors on Graft Outcomes: An Analysis of the Optn/unos Database
E. Montagud-Marrahi¹, F. Ausania², Y. Fundora², A. Amor³, E. Esmatjes³, J. Ferrer², I. Revuelta¹, D. Cucchiari¹, J. Rovira⁴, M. Musquera⁵, C. Fondevila², F. Diekmann¹, P. Ventura-Aguiar¹
¹Nephrology and Kidney Transplantation Department, Hospital Clinic de Barcelona, Barcelona, Spain, ²Hepatobiliopancreatic and Liver Transplant Department, Hospital Clinic de Barcelona, Barcelona, Spain, ³Endocrinology Department, Hospital Clinic de Barcelona, Barcelona, Spain, ⁴Laboratori Experimental de Nefrologia I Trasplantament (LENIT), CRB CELLEX, Fundació Clínic, IDIBAPS, Hospital Clinic de Barcelona, Barcelona, Spain, ⁵Urology Department, Hospital Clinic de Barcelona, Barcelona, Spain
*Purpose: Hyperglycemia requiring insulin treatment is frequent in critically ill patients and potential pancreas donors. Information on the impact of donor insulin use on pancreas…
2021 American Transplant Congress
Insulin Secretion and Insulin Resistance Trajectories Over 1 Year After Kidney Transplantation: A Multicenter Prospective Cohort Study
B. Jun Bae, C. Oh
Department of Surgery, Ajou University Medical School, Suwon, Korea, Republic of
*Purpose: We investigated the changing patterns of insulin secretion and resistance and risk factors contributing to the development of post-transplant diabetes mellitus (PTDM) in kidney…
2021 American Transplant Congress
Lacripep^TM-like Peptide N-104 Promotes Beta Cell Proliferation in Murine Pancreatic Islets
M. Ma, P. Chhabra, K. Fread, K. Dias Teixeira, G. Laurie, K. Brayman
University of Virginia Health System, Charlottesville, VA
*Purpose: To monitor time-dependent cellular changes, with emphasis on beta cell regeneration, in pancreatic islets following treatment with LacripepTM-like peptide N-104 by mass cytometry. Background:…
2020 American Transplant Congress
Generation of Insulin-Producing Cells via Multiplex Epigenetic Engineering of Human Somatic Cells in 2 Weeks
R. A. Naqvi¹, W. Zhang¹, A. Isidan¹, C. Evans-Molina², J. A. Fridell¹, P. Li¹, B. Ekser¹
¹Division of Transplant Surgery, Indiana University, Indianapolis, IN, ²Diabetes Research Center, Indiana University, Indianapolis, IN
*Purpose: Stem cell-derived β-cells not only promise a renewable supply of insulin-producing cells with negligible immunosuppression but may also provide a substrate for the identification…
2020 American Transplant Congress
Quantifiable Loss of Insulin Secretory Granules in Delayed Endocrine Pancreas Graft Function in Comparison to Controls
C. B. Drachenberg¹, J. C. Papadimitriou¹, J. R. Scalea², A. Haririan³, R. Ugarte³, S. Niederhaus², J. Bromberg²
¹Pathology, University of Maryland, Baltimore, MD, ²Surgery, University of Maryland, Baltimore, MD, ³Medicine, University of Maryland, Baltimore, MD
*Purpose: Approximately 1/3 of pancreas transplant fail to gain glycemic control in the first days/weeks posttransplantation, requiring exogenous insulin administration. Delayed endocrine pancreas graft function…
2020 American Transplant Congress
Bone Marrow Mesenchymal Stem Cells Improve Rat Islet Angiogenesis by Upregulating of ISL1 and VEGF-A
Y. Wang¹, J. Wang², X. Ding²
¹Department of Renal Transplantation, Nephropathy Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, China, ²Department of Renal Transplantation, Nephropathy Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
*Purpose: Islet transplantation is an important therapy to cure diabetes, but poor angiogenesis in the early stage of islet transplantation is one of the main…
2020 American Transplant Congress
AIPCs Home to and Engraft in the Pancreas When Injected Intravenously
J. B. Pollett¹, N. Thai²
¹Imagine Pharma, Pittsburgh, PA, ²Allegheny Health Network, Pittsburgh, PA
*Purpose: AIPCs (Activated Islet Proliferating Cells) are a recently developed cell population generated from isolated islets of mice and humans. AIPCs are over 65% CD133-,…
2020 American Transplant Congress
Beta Cell Replacement Therapy in Nonuremic Patients with Brittle T1DM Allows for Durable Long Term Insulin Independence Halting Progression of Secondary Diabetic Complications
P. J. Bachul¹, D. J. Grybowski¹, R. Anteby², L. Basto¹, L. Perea¹, K. Golab¹, L. Wang¹, M. Tibudan¹, A. Perez-Gutierrez¹, M. Komorniczak³, A. Lucander¹, P. Borek¹, M. Dimitrov¹, J. Fung¹, P. Witkowski¹
¹Surgery, University of Chicago, Chicago, IL, ²Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ³Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
*Purpose: Beta cell replacement therapy in form of pancreas or islet transplantation is the only effective treatment for patients suffering from hypoglycemic unawareness despite intensive…