Articles tagged "Insulin"

2022 American Transplant Congress
Decellularized Human Pancreatic Extracellular Matrix-Based Physiomimetic Microenvironment for Human Islet Culture
A. Asthana¹, D. Chaimov¹, R. Tamburrini², S. J. Walker³, G. Orlando¹
¹Wake Forest Baptist Medical Center, Winston-Salem, NC, ²University of Wisconsin Hospital and Clinics, Madison, WI, ³Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC
*Purpose: Maintenance of human islet viability and function ex vivo can be a significant bottleneck for both regenerative medicine as well as tissue engineering applications.…
2022 American Transplant Congress
Assessment of Insulin Utilization for Early Post-Transplant Glycemic Control in Liver Transplant
L. F. Borges, K. Gutierrez, T. A. Sparkman, J. Banbury
UAB Hospital, Birmingham, AL
*Purpose: Transient hyperglycemia after liver transplant (LT) is common due to the use of high-dose steroids at the time of transplant, but some patients may…
2022 American Transplant Congress
Pancreatic Islets Engineered with Thrombomodulin Show Enhanced Engraftment in an Intraportal Transplantation Model by Mitigating Instant Blood-Mediated Inflammatory Reactions
A. Turan¹, L. Zhang², M. Tarique², V. Ulker², E. Yolcu³, H. Shirwan³
¹Molecular Microbiology and Immunology, University of Missouri at Columbia, Columbia, MO, ²Department of Child Health, University of Missouri at Columbia, Columbia, MO, ³Child Health and Molecular Microbiology and Immunology, University of Missouri at Columbia, Columbia, MO
*Purpose: IBMIR is a major culprit of early islet loss post-transplant. Thrombomodulin (TM) is an anti-coagulant and cofactor of activated Protein C (APC) that perpetuates…
2022 American Transplant Congress
Successful Utilization of Advanced Diabetes Technology to Optimize Glucose Control as a Bridge to Simultaneous Liver and Pancreas Transplantation
M. M. Stumpf¹, S. Lee¹, E. Marriner¹, S. Rao¹, J. Oberholzer², S. Pelletier³
¹University of Virginia, Charlottesville, VA, ²University of Illinois at Chicago, Charlottesville, VA, ³University of Virginia Health System, Charlottesville, VA
*Purpose: We present the case of a 20 year old female with history of autoimmune hepatitis diagnosed in 2014, treated with tacrolimus, and insulin dependent…
2022 American Transplant Congress
Generation Of Insulin Producing Cells From Pancreatic Tissue With Long Standing Type 1 Diabetes
Y. Garciafigueroa, J. B. Pollett, N. L. Thai, R. Bottino
Imagine Pharma, Pittsburgh, PA
*Purpose: AIPCs (Activated Islet Proliferating Cells), are a novel cell population from isolated human islets obtained using a simple culture protocol that can generate cells…
2022 American Transplant Congress
Evaluation of GLP-1 Receptor Agonist Use in the Solid Organ Transplant Population
S. E. Lawrence, M. R. Norvell, K. Schwarz, B. Crowther, P. Klem
Pharmacy, University of Colorado Hospital, Aurora, CO
*Purpose: The purpose of this study was to evaluate the utilization of and identify opportunities to optimize the use of glucagon-like peptide-1 receptor agonist (GLP-1…
2022 American Transplant Congress
Voxelated Bioprinting of Mechanically Robust Multiscale Porous Scaffolds for Islet Transplantation
J. Zhu, Y. He, Y. Wang, J. Oberholzer, L. Cai
University of Virginia, Charlottesvle, VA
*Purpose: Classical microencapsulation technologies for islet transplantation faces two major challenges associated with individual microcapsules. First, due to long-term gravity individual microcapsules often aggregate to…
2022 American Transplant Congress
Characterization of Activated Islet Proliferating Cells (AIPCs) During Maturation to Pseudo-Islets
Y. Garciafigueroa, J. B. Pollett, N. Thai, R. Bottino
Imagine Pharma, Pittsburgh, PA
*Purpose: We have previously described a novel population of cells developed from human islets called AIPCs (Activated Islet Proliferating Cells). AIPCs co-express CD133, glucagon and…
2022 American Transplant Congress
Preclinical Evaluation of Functional Survival of Stem Cell Derived Islets Microencapsulated in Alginate with CXCL12 in Non-Human Primates without Immunosuppression
M. C. Poznansky
Vaccine and Immunotherapy Center, Massachusetts General Hospital, Charlestwon, MA
*Purpose: Human stem cell-derived islet-like cells (SC-islets) represent a sustainable source for beta-cell replacement to achieve a functional cure for type 1 diabetes. We previously…
2021 American Transplant Congress
Islet Isograft Transplantation Improves Insulin Sensitivity in a Murine Model of Type 2 Diabetes
S. Lim, M. Choi, M. Kim, Y. Wee, H. Kwon, C. Jung, Y. Kim, D. Han, S. Shin
Asan Medical Center, Seoul, Songpa, Korea, Republic of
*Purpose: Type 2 diabetes develops in the presence of chronic overnutrition and genetic susceptibility, and causes insulin resistance and relative insulin deficiency. We hypothesized that…

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