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Articles tagged "Infection"

  • 2017 American Transplant Congress

    Infections and Outcomes in Renal Transplantation Patients Using Alemtuzumab for Induction Immunosuppression: Preliminary Results.

    K. Korneffel, B. Gehring, G. Mitro, O. Aboderin, S. Makkar, W. Han, M. Rees, J. Ortiz.

    Surgery, University of Toledo College of Medicine, Toledo, OH

    Introduction: Alemtuzumab (Ale) is a monoclonal antibody targeting CD52+ lympocytes. We sought to determine the impact of Ale immunodepletion, with steroid freedom for low risk…
  • 2017 American Transplant Congress

    Effect of Academic Detailing with Prescribers as an Antimicrobial Stewardship Intervention in Solid Organ Transplant Patients.

    M. So,1 A. Morris,1,2 C. Bell,2 A. Humar,1 S. Husain.1

    1University Health Network, Toronto, ON, Canada; 2Sinai Health System, Toronto, ON, Canada

    IntroductionThe role of academic detailing (AD) as an antimicrobial stewardship intervention, where the steward meets the prescribers in their practice setting to provide personal educational…
  • 2017 American Transplant Congress

    Poor Predictability of Quantiferon-TB Assay in Recipients and Donors for Tuberculosis Development After Kidney Transplantation in an Intermediate-TB-Burden Country.

    J. Yang,1 J. Ryu,1 J. Jang,2 J.-G. Lee,2 C. Ahn.1

    1Transplantation Center, Seoul National University Hospital, Seoul, Republic of Korea; 2Transplantation Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea

    Background. Tuberculosis (TB) is a common opportunistic infection after kidney transplantation (KT). Quantiferon-TB Gold In-Tube test (QFT) is widely used for assessing latent TB; however,…
  • 2017 American Transplant Congress

    TB Chemoprophylaxis Post Transplantation in West London.

    Y. Al-Mula Abed,1 R. Charif,2 O. Kon,3 D. Taube.2

    1Dept of Renal Medicine, East and North Hertfordshire NHS Trust, Stevenage, United Kingdom; 2Kidney and Transplant Centre, Imperial College NHS Trust, London, United Kingdom; 3TB Service and Chest Dept, Imperial College NHS Trust, London, United Kingdom

    Introduction: Active Tuberculosis (TB) is common post solid organ transplantation (SOT). Incidence post SOT in Europe is reported to be between 0.7–5%. Isoniazid (INH) is…
  • 2017 American Transplant Congress

    Identifying Risk of Sepsis Early: A Way to Improve Outcomes for Patients with Early Allograft Dysfunction After Liver Transplantation?

    D. Hoyer, T. Benko, G. Sotiropoulos, A. Paul, F. Saner.

    General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany

    Early Allograft Dysfunction (EAD) after Liver Transplantation (LT) is associated with increased morbidity and mortality, which is strongly associated with sepsis/septic shock. Aim of this…
  • 2016 American Transplant Congress

    An Analysis of Non-Tuberculous Mycobacteria (NTM) Infection and Colonization in Lung Transplant Recipients (LTRs) Post-Transplant: A Single Center Matched Cohort Study.

    H. Kozlowski,1,2 D. Kabbani,3 C. Chaparro,1,2 L. Singer,1,2 C. Rotstein,1,2 S. Keshavjee,1,2 S. Husain.1,2

    1University of Toronto, Toronto, ON, Canada; 2Toronto General Hospital, Toronto, ON, Canada; 3University of Alberta, Edmonton, AB, Canada.

    PurposeNTM is a common infection after Lung transplantation. The role of presence of granuloma in the explanted lungs of LTRs in subsequent development of infection…
  • 2016 American Transplant Congress

    Three Months of Weekly Rifapentine Plus Isoniazid for Latent Tuberculosis Treatment in Solid Organ Transplant Candidates.

    B. Knoll,1 R. Nog,1 Y. Wu,2 A. Dhand.1

    1Medicine, Division of Infectious Diseases, Westchester Medical Center, Valhalla, NY; 2Division of Transplant and Hepatobiliary Surgery, Westchester Medical Center, Valhalla, NY.

    Purpose: Although isoniazid 300 mg daily for 9 months is the recommended regimen for latent tuberculosis infection (LTBI) in solid organ transplant (SOT) candidates, its…
  • 2016 American Transplant Congress

    Low Pretransplant BMI/Weight and Changes in Posttransplant T Cell Exhaustion Levels Are Associated with Viremia/Viral Infection in Pediatric Kidney Transplantation in the First Post-Transplant Year – A Report from the IMPACT Study Consortium.

    R. Ettenger,1 H. Chin,2 P. Grimm,3 K. Kesler,2 E. Reed,4 M. Sarwal,5 B. Warshaw,6 E. Tsai,1 A. Kirk.7

    1Pediatrics, UCLA, LA, CA; 2Rho, Chappel Hill, NC; 3Pediatrics, Stanford Univ, Palo Alto, CA; 4Pathology, UCLA, LA, CA; 5Surgery, UCSF School of Medicien, SF, CA; 6Pediatric Nephrolgoy, Children's Healthcare of Atlanta, Atlanta, GA; 7Surgery, Duke University, Durham, NC.

    Viral consequences of immunosuppression (IS) in pediatric(ped)kidney(kid)transplantation(Tx)patients(pts) are not fully known. We prospectively examined the immunologic and infectious (inf) history of 106 ped Tx pts…
  • 2016 American Transplant Congress

    Evaluation of a Novel Global Immunity Assay to Predict Infections in Organ Transplant Recipients.

    M. Mian, A. Humar, S. Keshwani, S. Husain, P. Ashton, S. Han, L. Singer, J. Kim, E. Renner, M. Bhat, D. Kumar.

    Multi-Organ Transplant, University Health Network, Toronto, Canada.

    BackgroundSimple standardized measures of global immunity may help predict the risk of infections post-transplant. The Quantiferon-Monitor (QFM) test is a novel interferon-γ (IFN-γ) release assay…
  • 2016 American Transplant Congress

    Clinical Impact of the Verigene® Blood Culture System on Rapid Diagnosis and Antibiotic Optimization in Bacteremic Solid Organ Transplant (SOT) Recipients.

    N. Law,1 G. Malat,3,4 D. Lee,1 A. Doyle,2 C. Emery,1,5 K. Kyle,5 K. Ranganna,2 M. Harhay,2 T. Bias.1,4

    1Division of Infectious Diseases and HIV Medicine, Drexel University College of Medicine, Philadelphia, PA; 2Division of Nephrology, Drexel University College of Medicine, Philadelphia, PA; 3Department of Surgery, Drexel University College of Medicine, Philadelphia, PA; 4Pharmacy, Hahnemann University Hospital, Philadelphia, PA; 5Microbiology, Hahnemann University Hospital, Philadelphia, PA.

    Background:Bloodstream infections are a major concern in SOT recipients and ineffective antibiotic therapy is strongly associated with poor outcomes. Rapid diagnostic tests (RDT) provide prompt…
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