Articles tagged "Infection"

2017 American Transplant Congress
Causes and Long-Term Consequences of Diarrhea After Kidney Transplantation.
A. Devresse,¹ F. Aulagnon,² A. Scemla,² L. Morin,² F. Lanternier,³ D. Anglicheau,² O. Lortholary,³ C. Legendre,² V. Avettand-Fenoel,⁴ J. Zuber.²
¹Nephrology Unit, Cliniques Universitaires Saint-Luc, Brussels, Belgium; ²Kidney Transplant and Intensive Care Unit, Hôpital Necker-Enfants Malades, AP-HP, Paris, France; ³Infectious and Tropical Diseases Unit, Hôpital Necker-Enfants Malades, AP-HP, Paris, France; ⁴Virology Unit, Hôpital Necker-Enfants Malades, AP-HP, Paris, France
BackgroundThe causes and effects of diarrhea on graft outcomes have been poorly investigated in a large cohort of well-phenotyped kidney transplant recipients (KT). The epidemiological…
2017 American Transplant Congress
Co-Stimulation Blockade to Minimize and Withdraw Long Term Calcineurin Inhibitors (CNI) in Simultaneous Pancreas and Kidney Transplant (SPK).
P. Stock,¹ R. Mannon,² B. Armstrong,³ D. Ikle,³ M. Robian,⁴ Y. Morrison,⁴ J. Odorico,⁵ J. Fridell,⁶ A. Mehta,⁷ K. Newell.⁷
¹UCSF, San Francisco; ²UAB, Birmingham, AL; ³Rho Inc, Chapel Hill, NC; ⁴NIH/NIAID, Bethesda, MD; ⁵UW, Madison, WI; ⁶IU, Indianapolis, IN; ⁷Emory University, Atlanta, GA
The NIH multicenter CTOT-15 trial tested the hypothesis that use of belatacept (bela) could minimize or eliminate long-term CNI use in simultaneous pancreas and kidney…
2017 American Transplant Congress
Kinetics of Cytomegalovirus (CMV) DNAemia in CMV Mismatch Solid Organ Transplant Patients with Primary CMV Infection.
C. Hernandez, D. Chiang, S. Fuentes, C. Cervera.
Medicine, University of Alberta, Edmonton, Canada
Despite antiviral prophylaxis, CMV infection is common in CMV mismatch (D+/R-) patients. We aimed to study the kinetics of CMV viral load in primary CMV…
2017 American Transplant Congress
Outcomes of Active Screening for Carbapenem-Resistant Enterobacteriaceae among Liver Transplant Recipients.
T. Bias,¹ G. Malat,¹ D. Lee,² S. Talluri,² K. Ranganna,² S. Epstein,² V. Patel,² S. Guy.³
¹Department of Pharmacy, Drexel University College of Medicine, Philadelphia, PA; ²Department of Medicine, Drexel University College of Medicine, Philadelphia, PA; ³Department of Surgery, Drexel University College of Medicine, Philadelphia, PA
Background: Preventive strategies to combat the transmission of Carbapenem-Resistant Enterobacteriaceae (CRE) include the use of active screening for CRE colonization; however, this approach is not…
2017 American Transplant Congress
TNF[part]-I After Kidney Transplantation.
B. Muth, B. Astor, D. Mandelbrot.
Department of Medicine, Division of Nephrology, University of Wisconsin, Madison, WI
Infliximab, adalimumab and etanercept are monoclonal antibodies which inhibit tumor necrosis factor alpha (TNF[part]-I) and are used in the treatment of inflammatory diseases such as…
2017 American Transplant Congress
Deceased Donors with a History of IV Drug Use and Donor Derived Hepatitis C Virus.
D. Kaul,¹ M. Clark,² M. Michaels,¹ S. Tlusty,² C. Wolfe.¹
¹OPTN Ad Hoc Disease Transmission Advisory Committee, Richmond, VA; ²UNOS, Richmond
Introduction:In 2015, the CDC reported a 172% increase in heroin-related deaths from 2010 to 2013. Deceased donors with IV drug use (IVDU) are at increased…
2017 American Transplant Congress
Facing Unintended Challenges of Increased Risk Donor Kidneys in a New Kidney Allocation Era.
A. Rahnemai-Azar,¹ J. Perkins,¹ A. Limaye,² N. Leca,³ C. Blosser,³ C. Johnson,³ S. Morrison,¹ R. Bakthavatsalam,¹ L. Sibulesky.¹
¹Abdominal Organ Transplantation, University of Washington Medical Center, Sattle, WA; ²Transplant Infectious Disease, University of Washington Medical Center, Sattle, WA; ³Transplant Nephrology, University of Washington Medical Center, Seattle, WA
Background: In 2014, the Organ Procurement and Transplantation Network (OPTN) approved a new kidney allocation system (KAS). One of the intended goals of this system…
2017 American Transplant Congress
Eight Years of Low-Dose Valganciclovir; Evaluating the Incidence and Risk Factors of CMV in Kidney Transplant Recipients.
S. El Hajj, M. Kim, J. Azzi, S. Gabardi.
Kidney Transplant, Brigham and Women's Hostpial, Boston, MA
Introduction: Cytomegalovirus (CMV) remains one the most clinically relevant and frequent post-transplant infections. Despite the availability of effective antiviral drugs, CMV continues to be of…
2017 American Transplant Congress
Factors in Association with Sepsis Differ Between Simultaneous Pancreas/Kidney and Single Kidney Transplant Recipients.
T. Schachtner,^1,2,3 M. Zaks,¹ A. Kahl,¹ P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charite Campus Virchow Clinic, Berlin, Germany; ³Charite and Max-Delbrück Center, Berlin Institute of Health BIH, Berlin, Germany
As immunosuppressive therapy and allograft survival have improved in simultaneous pancreas/kidney transplant recipients (SPKTRs), the increased incidence of infection has become a major hurdle of…
2017 American Transplant Congress
NFAT-Regulated Cytokine Gene Expression for Immune Monitoring in Kidney Transplant Recipients – A Randomized Controlled Trial.
A. Webber,¹ V. Tatapudi,² C. Leung,³ F. Vincenti.^1,3
¹Division of Nephrology, UCSF, San Francisco, CA; ²Division of Nephrology, NYUMC, New York, NY; ³Surgery, UCSF, San Francisco, CA
Purpose: To demonstrate that a pharmacodynamics assay using Real Time (RT)-PCR to measure residual expression (RE) of nuclear factor of activated T cell (NFAT)-dependent cytokines…