Articles tagged "Infection"

2017 American Transplant Congress
Factors in Association with Sepsis Differ Between Simultaneous Pancreas/Kidney and Single Kidney Transplant Recipients.
T. Schachtner,^1,2,3 M. Zaks,¹ A. Kahl,¹ P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charite Campus Virchow Clinic, Berlin, Germany; ³Charite and Max-Delbrück Center, Berlin Institute of Health BIH, Berlin, Germany
As immunosuppressive therapy and allograft survival have improved in simultaneous pancreas/kidney transplant recipients (SPKTRs), the increased incidence of infection has become a major hurdle of…
2017 American Transplant Congress
NFAT-Regulated Cytokine Gene Expression for Immune Monitoring in Kidney Transplant Recipients – A Randomized Controlled Trial.
A. Webber,¹ V. Tatapudi,² C. Leung,³ F. Vincenti.^1,3
¹Division of Nephrology, UCSF, San Francisco, CA; ²Division of Nephrology, NYUMC, New York, NY; ³Surgery, UCSF, San Francisco, CA
Purpose: To demonstrate that a pharmacodynamics assay using Real Time (RT)-PCR to measure residual expression (RE) of nuclear factor of activated T cell (NFAT)-dependent cytokines…
2017 American Transplant Congress
Transplantation of Organs from Donors with Hepatitis C: The Potential to Substantially Increase Transplant Activity.
P. Trotter,^1,2 M. Robb,² I. Ushiro-Lumb,² J. Powell,³ C. Watson,¹ J. Bradley,¹ J. Neuberger.^2,4
¹Department of Surgery, University of Cambridge, Cambridge, United Kingdom; ²Organ Donation and Transplantation, National Health Service Blood and Transplant, Bristol, United Kingdom; ³Hepatic-Pancreatico-Biliary Surgical Services and Edinburgh Transplant Unit, Royal Infirmary Edinburgh, Edinburgh, United Kingdom; ⁴The Liver Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom
Introduction. Organs from hepatitis C virus positive (HCV+ve) donors are commonly declined for transplantation because of the risk of disease transmission, but new direct acting…
2017 American Transplant Congress
Donor Factors Show Low Impact on Patient and Kidney Allograft Outcomes: A Paired Analysis of Left/Right Deceased Donor Kidney Pairs.
T. Schachtner,^1,2,3 M. Stein,² P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charite Campus Virchow Clinic, Berlin, Germany; ³Charite and Max-Delbrück Center, Berlin Institute of Health BIH, Berlin, Germany
The impact of donor factors on kidney allograft outcomes and infectious complications has been suggested in many previous studies. However, analyses of left/right donor kidney…
2017 American Transplant Congress
Incidence of Cytomegalovirus Infection Among Liver Transplant Recipients Maintained on a Cyclosporine vs. Tacrolimus-Based Immunosuppression Regimen.
C. Burrelli, M. Bradley, S. Pouch, E. Elkhammas, H. Winters.
The Ohio State University Wexner Medical Center, Columbus, OH
Background: Cytomegalovirus (CMV) is the most common viral pathogen that affects patient outcomes after liver transplant. Potent immunosuppressive agents predispose patients to an increased risk…
2017 American Transplant Congress
Antibiotic Conservatorship in Orthotopic Liver Transplantation.
J. Yee,² D. Clark,² R. Hogen,^1,2 K. Dhanireddy,¹ S. Biswas,² J. Cobb,² K. Matsushima,² D. Grabo,² A. Strumwasser.²
¹Solid Organ Transplantation, Keck Hospital of USC, Los Angeles, CA; ²Trauma, Acute Care Surgery, Surgical Critical Care, LAC+USC Medical Center, Los Angeles, CA
Post-orthotopic liver transplantation (OLT) infections, especially multidrug resistant organisms (MDRO), are implicated in poorer outcomes, fueling efforts to elucidate risk factors for hospital acquired infections.…
2017 American Transplant Congress
Total Pancreatectomy and Islet Autotransplantation into the Liver of a Patient with Previous Hepatitis C Infection.
A. Rajab,¹ J. Buss,¹ P. Hart,² D. Conwell,² S. Black,¹ K. Washburn.¹
¹Transplant Surgery, The Ohio State Wexner Medical Center, Columbus, OH; ²Internal Medicine, The Ohio State Wexner Medical Center, Columbus, OH
Hepatic parenchymal disease such as hepatitis has been considered a relative contraindication to islet transplantation as the islets are infused into the liver. Islet transplantation…
2017 American Transplant Congress
Acute Mouse CMV Infection Abrogates Transplant Tolerance by Modulating Myeloid Cell Differentiation and Function: A Possible Role for Transcription Factor RORγt.
A. Dangi,¹ L. Zhang,¹ X. Zhang,^2,3 Z. Zhang,^2,3 X. Luo.^1,2,3
¹Nephrology and Hypertension, Northwestern University, Chicago, IL; ²Comprehensive Transplant Center, Northwestern University, Chicago, IL; ³Comprehensive Transplant Center, Northwestern University, Chicago, IL
Cytomegalovirus (CMV) infection has long been associated with graft-dysfunction and rejection in transplant-recipients. Nevertheless, precise understanding of underlying molecular mechanisms remains unclear. Here, we investigated…
2017 American Transplant Congress
Clinically Relevant Immunosuppression Promotes MCMV Reactivation and Dissemination Following Transplantation of Latently Infected Kidneys.
Z. Zhang,¹ S. Yan,¹ L. Zhao,¹ S. Kurian,² M. Hummel,¹ D. Salomon,² M. Abecassis.¹
¹Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago; ²Dept. of Molecular & Experimental Medicine, The Scripps Research Institute, La Jolla
Reactivation of latent Cytomegalovirus (CMV) is an important problem facing clinical transplantation. We have previously described a model for murine CMV (MCMV) reactivation following kidney…
2017 American Transplant Congress
Improving Donor Screening for Cytomegalovirus (CMV): Is CMV IgG Avidity Better Than CMV IgM?
H. Prince,¹ M. Nowicki.^1,2
¹Donor Screening Laboratory, VRL Eurofins, Los Angeles, CA; ²Mendez National Institute of Transplantation Foundation, Los Angeles, CA
Study purpose: It is standard practice to test organ donors for CMV IgM as a marker of recent CMV infection (defined as primary infection within…