Articles tagged "Infection"

2018 American Transplant Congress
Colistin (COL) in Solid Organ Transplant Recipients (SOTR): Friend or Foe?
K. Neyra, C. Huauya Leuyacc, C. Kovacs, V. Athans, E. Cober.
Cleveland Clinic, Cleveland, OH.
Background: Data on COL use in SOTR are lacking. In other populations, high dose (HD) COL (>4.4mg/kg/day) has been associated with clinical and microbiologic cure…
2018 American Transplant Congress
Urinary Tract Infections May Be Associated with De Novo Donor-Specific Anti-Human Leucocyte Antigen Antibodies: Single-Center Study
M. Everly,¹ A. Babu,¹ K. Briley,² P. Bolin,² S. Kendrick,³ H. Jones,³ K. McLawhorn,³ A. Maldonado,⁴ C. Haisch,² D. Leeser,² L. Rebellato.²
¹Terasaki Research Institute, Los Angeles; ²East Carolina University, Greenville, NC; ³Eastern Nephrology Associates, Greenville, NC; ⁴Vidant Medical Center, Greenville, NC.
Introduction: We have recently shown that immunosuppression reduction with BK virus is associated with the development of de novo donor anti-human leukocyte antigen-specific antibodies (dnDSA).…
2018 American Transplant Congress
Prospective, Multi-Center Observational Study of Cell-Mediated Immunity for Cytomegalovirus Infection in Kidney Transplant Recipients
D. Kumar,¹ P. Chin-Hong,² L. Kayler,³ D. Wojciechowski,⁴ A. Limaye,⁵ O. Gaber,⁶ S. Ball,⁷ A. Mehta,⁸ T. Blanchard,⁹ C. Kotton.⁴
¹UHN, Toronto, Canada; ²UCSF, San Francisco; ³ECMC, Buffalo; ⁴MGH, Boston; ⁵UOWMC, Seattle; ⁶WCMC, Houston; ⁷UHB, Birmingham, United Kingdom; ⁸EmoryU, Atlanta; ⁹Oxford Diag, Marlborough.
Background:T-cell-mediated immunity (CMI) is crucial for the control of CMV infection post-transplant. We evaluated a novel EliSpot assay to determine whether CMI results could predict…
2018 American Transplant Congress
Origin and Pattern of Human Polyomaviruses Replication after Kidney Transplantation: A Prospective Study
E. Favi,¹ S. Delbue,² C. Colico,¹ P. Ferrante,² S. Villani,² I. Perna,² N. Mondoni,² A. Giussani,¹ L. Clementoni,¹ P. Messa,³ M. Ferraresso.¹
¹Kidney Transplantation, Fondazione IRCCS Ca' Granda, Milan, Italy; ²Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy; ³Nephrology, Fondazione IRCCS Ca' Granda, Milan, Italy.
Background. Human Polyomaviruses (HPyVs) are able to establish latent infection in the kidney of the host. Immunosuppression is recognized risk factor for HPyVs reactivation. Besides…
2018 American Transplant Congress
Clinical Outcomes of Kidney Transplant Recipients Infected with Hepatitis C Virus and Treated with Direct-Acting Antiviral Therapy
M. Alkadi,¹ E. Abuhelaiqa,¹ M. Derbala,² O. Fituri,¹ J. Mahmoud,³ M. Jarman,³ M. Asim,¹ A. Aziz,¹ A. Nauman,¹ A. Hamdi,¹ Y. Medhat,² S. Al Kaabi,² H. Al-Malki.¹
¹Medicine-Nephrology, Hamad Medical Corporation, Doha, Qatar; ²Medicine-Gastroenterology, Hamad Medical Corporation, Doha, Qatar; ³Surgery-Transplant, Hamad Medical Corporation, Doha, Qatar.
Introduction:Hepatitis C virus (HCV) infection has negative impact on patient and graft survival in kidney transplant recipients. In the past, treatment of HCV infection post…
2018 American Transplant Congress
JC Virus-Associated Nephropathy in Renal Transplant Recipient
G. Huang,¹ M. Wang,² X. Chen,¹ S-.C. Yang,³ L. Chen.¹
¹Department of Organ Transplantation, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; ²Sun Yat-sen University, Guangzhou, China; ³Department of Pathology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Background: JC virus (JCV) inflection is more common than BK virus (BKV) in general population. But in kidney transplants, polyomavirus nephropathy (PVAN) is primarily caused…
2018 American Transplant Congress
Daptomycin Minimum Inhibitory Concentration (MIC) of Vancomycin Resistant Enterococcal (VRE) Blood Isolates Correlates with Allograft Failure in Orthotopic Liver Transplant (OLT) Recipients
R. Lee,¹ G. Haidar,² J. Lewis,³ S. Arif,⁴ J. Hand,⁵ E. Holaday,⁶ H. Clauss,⁶ J. Goldman,⁷ A. Nellore.¹
¹University of Alabama at Birmingham, Birmingham, AL; ²University of Pittsburgh Medical Center, Birmingham, AL; ³University of Virginia, Charlottesville, VA; ⁴Duke University, Durham, NC; ⁵Oschner Medical Center, New Orleans, LA; ⁶Department of Internal Medicine, Temple University, Philadelphia, PA; ⁷Temple University, Philadelphia, PA; ⁸Swedish Medical Center, Seattle, WA.
Background: Enterococci are one of the leading causes of nosocomial infection in after OLT. Unfortunately, treatment options for enterococci that are resistant to first-line agents…
2018 American Transplant Congress
The Role of Pre-Emptive Antibiotic Therapy in Kidney Recipients of Donors with Urine-Only Positive Cultures
P. Cabrera,¹ A. Centeno,¹ J. Revollo,¹ J. Camargo.²
¹Department of Pharmacy, Jackson Memorial Hospital, Miami, FL; ²Department of Medicine, University of Miami Miller School of Medicine, Miami, FL.
Background: Donor derived infections (DDIs) can lead to significant morbidity and mortality in solid organ transplant patients. In recent years, the disparity between the need…
2018 American Transplant Congress
Burden of Infectious Complications after Upper Extremity Allotransplantation: A Matched Cohort Study
A. Conrad,^1,2,3 P. Petruzzo,^4,5 J. Kanitakis,⁶ A. Gazarian,⁷ L. Badet,^3,8 P. Vanhems,^3,9 O. Thaunat,^1,3,10 E. Morelon,^1,3,10 A. Sicard.^1,3
¹Department of Transplantation, Nephrology and Clinical Immunology, Hospices Civils de Lyon (HCL), Lyon, France; ²Department of Infectious Diseases and Tropical Medicine, HCL, Lyon, France; ³Claude Bernard Lyon 1 University, Lyon, France; ⁴Department of Transplantation, HCL, Lyon, France; ⁵Department of Surgery, University of Cagliari, Cagliari, Italy; ⁶Department of Dermatology, HCL, Lyon, France; ⁷Clinique du Parc, Lyon, France; ⁸Department of Urology and Transplantation, HCL, Lyon, France; ⁹Infection Control and Epidemiology Unit, HCL, Lyon, France; ¹⁰INSERM U1111, International Center for Infectiology Research, Lyon, France.
This study aimed to assess the infectious risk after upper extremity allotransplantation (UEA), a non-vital transplantation procedure requiring lifelong immunosuppression. A matched cohort study was…
2018 American Transplant Congress
HCV Ab+/NAT- Organ Donors, and the Challenges of 'Eclipse Windows': Analysis of the OPTN/UNOS Ad Hoc Disease Transmission Advisory Committee (DTAC)
C. Wolfe, S. Tlusty, G. Vece, R. Sawyer, R. Bag, G. Berry, J. Bucio, L. Danziger-Isakov, D. Goldberg, C. Ho, D. Florescu, D. Klassen, R. La Hoz, K. Lilly, A. Mehta, M. Malinis, M. Nalesnik, N. Theodoropoulos, P. Wood, M. Michaels.
DTAC, United Network for Organ Sharing, Richmond, VA.
Introduction: In 2017, CDC reported new hepatitis C (HCV) cases had tripled over 5 years, mainly due to intravenous drug use (IVDU). As the proportion…