Articles tagged "Infection"

2019 American Transplant Congress
Healthcare Resource Utilization and Associated Costs of Cytomegalovirus Management among Solid Organ Transplant Recipients
W. Y. Cheng¹, P. Thompson-Leduc¹, H. Cheung¹, R. Avery², T. Bo³, S. Chavan³, M. Duh¹, I. Hirji³
¹Analysis Group, Inc., Boston, MA, ²Johns Hopkins University, Baltimore, MD, ³Shire, Cambridge, MA
*Purpose: Solid organ transplant (SOT) recipients who develop cytomegalovirus (CMV) infection and disease are at increased risk of morbidity. We quantified real-world healthcare resource utilization…
2019 American Transplant Congress
Eight-Year Outcomes Following ABO-Incompatible Kidney Transplantation Performed after Desensitization by Antigen-Unspecific Immunoadsorption Devices
C. Speer¹, F. Kälble¹, L. Pego da Silva¹, C. Nusshag¹, M. Schaier¹, C. Süsal², C. Sommerer¹, M. Zeier¹, C. Morath¹
¹Nephrology, University of Heidelberg, Heidelberg, Germany, ²Immunology, University of Heidelberg, Heidelberg, Germany
*Purpose: Owing to the unmet need of available kidney grafts, ABO-incompatible kidney transplantation (KTX) has been established to enlarge the possible donor pool. The current…
2019 American Transplant Congress
Impact Of Selective Cd28 Blockade On Protective Immunity To A Murine Epstein-Barr Virus Homolog
R. L. Crepeau, J. A. Elengickal, M. L. Ford
Surgery, Emory University, ATLANTA, GA
*Purpose: CTLA-4Ig blocks CD80/CD86, the ligands for both CD28 and CTLA-4. Thus, in addition to the intended effect of blocking CD28-mediated costimulation, CTLA4-Ig also has…
2019 American Transplant Congress
Transcriptional Changes in PBMC Associated with Development of Infection and Rejection in Older and Younger Kidney Transplant Recipients
J. Schaenman¹, M. Rossetti², E. Liang¹, O. E. Beaird¹, S. Bunnapradist³, E. F. Reed², S. Cole⁴
¹Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, ²Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, ³Division of Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁴Division of Hematology-Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: Changes in immune response are central to vulnerability to infection and rejection, especially for the growing numbers of older kidney transplant recipients. We sought…
2019 American Transplant Congress
Efficacy of Filgrastim in Solid Organ Transplant Recipients
M. Spinner¹, K. Gaffney¹, S. Gundling²
¹Pharmacy, Cleveland Clinic, Cleveland, OH, ²University of Pittsburgh School of Pharmacy, Pittsburgh, PA
*Purpose: Neutropenia frequently occurs after solid organ transplantation (SOT) due to immunosuppression, antiviral prophylaxis, or viral infections. Immunosuppression reduction or antiviral prophylaxis minimization can lead…
2019 American Transplant Congress
Evaluation of Induction Immunosuppression in Elderly Kidney Transplant Recipients
C. Pham, S. Kuten, A. Rogers, R. Knight, D. T. Nguyen, E. Graviss, A. Gaber
Houston Methodist Hospital, Houston, TX
*Purpose: It is well recognized that elderly transplant recipients experience lower rates of acute rejection along with higher rates of infectious death compared to their…
2019 American Transplant Congress
Murine Cytomegalovirus Infection Down-Regulates Receptor Tyrosine Kinase MerTK on Macrophages to Abrogate Allograft Tolerance
S. Yu, A. Dangi, M. Burnette, X. Luo
Division of Nephrology, Department of Medicine, Duke Transplant Center, Duke University Medical Center, Durham, NC
*Purpose: Cytomegalovirus (CMV) is one of the most common pathogens infecting solid organ transplant recipients. We recently showed that (1) CMV infection impairs the induction…
2019 American Transplant Congress
Identifying the Proverbial “Needle in the Arm” with Natural Language Processing
G. R. Vece, J. Foutz, A. Placona
Department of Research, United Network for Organ Sharing, Richmond, VA
*Purpose: Donors with a history of IVDU are associated with increased disease transmission risk; However, OPTN forms only request broad historical details relating to donor…
2018 American Transplant Congress
Ciprofloxacin for BK Viremia Prophylaxis in Kidney Transplant Recipients: Results of a Prospective, Randomized Controlled Trial
S. Patel, S. Kuten, R. Knight, J. Nolte, D. Nguyen, E. Graviss, L. Moore, I. Agboli, C. Pham, A. Gaber.
Houston Methodist Hospital, Houston, TX.
Fluoroquinolone (FQ) antibiotics have in vitro activity against BK virus, with several reports indicating they may reduce the risk of BK infection in kidney transplant…
2018 American Transplant Congress
Proton-Pump Inhibitor Utilization is Associated with Higher Rates of Clostridium difficile Infection and Hypomagnesemia after Kidney Transplant
G. Kipp,² K. Dancsecs,¹ A. Lapping.¹
¹School of Pharmacy, Duquesne University, Pittsburgh, PA; ²Abdominal Transplant, Allegheny General Hospital, Pittsburgh, PA.
The purpose of this project was to identify how many kidney transplant patients were taking a proton pump inhibitor (PPI) after kidney transplant at our…