Articles tagged "Infection"

2019 American Transplant Congress
Gut Microbiome And Acute Rejection After Kidney Transplantation
H. Cho¹, Y. Yang¹, J. Kim², J. Moon², J. Jeong², J. Park³, M. Kwak⁴, B. Kim⁴, D. Kim², J. Lee⁵, B. Kim⁶, Y. Kim², H. Lee²
¹Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea, Republic of, ²Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ³Internal Medicine, Kangwon National University Hospital, Chuncheon, Korea, Republic of, ⁴ChunLab Inc., Seoul, Korea, Republic of, ⁵Internal Medicine, Seoul National University, Boramae Hospital, Seoul, Korea, Republic of, ⁶Hallym University, Chuncheon, Korea, Republic of
*Purpose: Acute rejection (AR) is a common complication in kidney transplantation (KT) and associated with reduced patient-graft survival. Recent studies have shown that the gut…
2019 American Transplant Congress
Treatment of Pseudomonas Infection with Beta-Lactams Including Ceftolozane-Tazobactam in Solid Organ Transplant Recipients
M. Henry¹, J. Puvvula², J. John Schoen¹, L. Puzniak³, J. Raddatz⁴, T. Van Schooneveld², S. Bergman¹
¹Nebraska Medicine, Omaha, NE, ²University of Nebraska Medical Center, Omaha, NE, ³Merck & Co., Inc, Kenilworth, NJ, ⁴Merck & Co., Inc, Kenilworth, NJ, NJ
*Purpose: Ceftolozane/Tazobactam (CT) is a potent anti-pseudomonal agent with broad gram-negative activity. Our academic medical center recommends the use of CT for patients with a…
2019 American Transplant Congress
Comparing the Rate of Opportunistic Infection after Renal Transplant between Alemtuzumab and Basiliximab for Induction Immunosuppression
J. A. Seaman¹, S. G. Westphal², F. Qiu³, D. Bremers⁴, D. Florescu⁵
¹College of Medicine, University of Nebraska Medical Center, Omaha, NE, ²Internal Medicine Division of Nephrology, University of Nebraska Medical Center, Omaha, NE, ³Biostatistics, University of Nebraska Medical Center, Omaha, NE, ⁴Donate Life, Nebraska Medicine, Omaha, NE, ⁵Internal Medicine Division of Infectious Disease, University of Nebraska Medical Center, Omaha, NE
*Purpose: The aim of our study was to compare the outcomes one-year after renal transplant with a focus on opportunistic infections in patients who received…
2019 American Transplant Congress
The Significance and Impact of Screening Preservation Fluid Cultures in Renal Transplant Recipients
A. Reticker, A. Lichvar, A. Gross, E. Benedetti, S. Patel
University of Illinois Hospital and Health Sciences System, Chicago, IL
*Purpose: Preservation fluid (PF) is necessary to maintain organ viability but serves as a vector for infection. The utility of routine PF screening and impact…
2019 American Transplant Congress
Healthcare Resource Utilization and Associated Costs of Cytomegalovirus Management among Solid Organ Transplant Recipients
W. Y. Cheng¹, P. Thompson-Leduc¹, H. Cheung¹, R. Avery², T. Bo³, S. Chavan³, M. Duh¹, I. Hirji³
¹Analysis Group, Inc., Boston, MA, ²Johns Hopkins University, Baltimore, MD, ³Shire, Cambridge, MA
*Purpose: Solid organ transplant (SOT) recipients who develop cytomegalovirus (CMV) infection and disease are at increased risk of morbidity. We quantified real-world healthcare resource utilization…
2019 American Transplant Congress
Eight-Year Outcomes Following ABO-Incompatible Kidney Transplantation Performed after Desensitization by Antigen-Unspecific Immunoadsorption Devices
C. Speer¹, F. Kälble¹, L. Pego da Silva¹, C. Nusshag¹, M. Schaier¹, C. Süsal², C. Sommerer¹, M. Zeier¹, C. Morath¹
¹Nephrology, University of Heidelberg, Heidelberg, Germany, ²Immunology, University of Heidelberg, Heidelberg, Germany
*Purpose: Owing to the unmet need of available kidney grafts, ABO-incompatible kidney transplantation (KTX) has been established to enlarge the possible donor pool. The current…
2019 American Transplant Congress
Impact Of Selective Cd28 Blockade On Protective Immunity To A Murine Epstein-Barr Virus Homolog
R. L. Crepeau, J. A. Elengickal, M. L. Ford
Surgery, Emory University, ATLANTA, GA
*Purpose: CTLA-4Ig blocks CD80/CD86, the ligands for both CD28 and CTLA-4. Thus, in addition to the intended effect of blocking CD28-mediated costimulation, CTLA4-Ig also has…
2019 American Transplant Congress
Transcriptional Changes in PBMC Associated with Development of Infection and Rejection in Older and Younger Kidney Transplant Recipients
J. Schaenman¹, M. Rossetti², E. Liang¹, O. E. Beaird¹, S. Bunnapradist³, E. F. Reed², S. Cole⁴
¹Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, ²Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, ³Division of Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁴Division of Hematology-Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: Changes in immune response are central to vulnerability to infection and rejection, especially for the growing numbers of older kidney transplant recipients. We sought…
2019 American Transplant Congress
Efficacy of Filgrastim in Solid Organ Transplant Recipients
M. Spinner¹, K. Gaffney¹, S. Gundling²
¹Pharmacy, Cleveland Clinic, Cleveland, OH, ²University of Pittsburgh School of Pharmacy, Pittsburgh, PA
*Purpose: Neutropenia frequently occurs after solid organ transplantation (SOT) due to immunosuppression, antiviral prophylaxis, or viral infections. Immunosuppression reduction or antiviral prophylaxis minimization can lead…
2019 American Transplant Congress
Evaluation of Induction Immunosuppression in Elderly Kidney Transplant Recipients
C. Pham, S. Kuten, A. Rogers, R. Knight, D. T. Nguyen, E. Graviss, A. Gaber
Houston Methodist Hospital, Houston, TX
*Purpose: It is well recognized that elderly transplant recipients experience lower rates of acute rejection along with higher rates of infectious death compared to their…