ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Infection"

  • 2019 American Transplant Congress

    Healthcare Resource Utilization and Associated Costs of Cytomegalovirus Management among Solid Organ Transplant Recipients

    W. Y. Cheng1, P. Thompson-Leduc1, H. Cheung1, R. Avery2, T. Bo3, S. Chavan3, M. Duh1, I. Hirji3

    1Analysis Group, Inc., Boston, MA, 2Johns Hopkins University, Baltimore, MD, 3Shire, Cambridge, MA

    *Purpose: Solid organ transplant (SOT) recipients who develop cytomegalovirus (CMV) infection and disease are at increased risk of morbidity. We quantified real-world healthcare resource utilization…
  • 2019 American Transplant Congress

    Eight-Year Outcomes Following ABO-Incompatible Kidney Transplantation Performed after Desensitization by Antigen-Unspecific Immunoadsorption Devices

    C. Speer1, F. Kälble1, L. Pego da Silva1, C. Nusshag1, M. Schaier1, C. Süsal2, C. Sommerer1, M. Zeier1, C. Morath1

    1Nephrology, University of Heidelberg, Heidelberg, Germany, 2Immunology, University of Heidelberg, Heidelberg, Germany

    *Purpose: Owing to the unmet need of available kidney grafts, ABO-incompatible kidney transplantation (KTX) has been established to enlarge the possible donor pool. The current…
  • 2019 American Transplant Congress

    Impact Of Selective Cd28 Blockade On Protective Immunity To A Murine Epstein-Barr Virus Homolog

    R. L. Crepeau, J. A. Elengickal, M. L. Ford

    Surgery, Emory University, ATLANTA, GA

    *Purpose: CTLA-4Ig blocks CD80/CD86, the ligands for both CD28 and CTLA-4. Thus, in addition to the intended effect of blocking CD28-mediated costimulation, CTLA4-Ig also has…
  • 2019 American Transplant Congress

    Transcriptional Changes in PBMC Associated with Development of Infection and Rejection in Older and Younger Kidney Transplant Recipients

    J. Schaenman1, M. Rossetti2, E. Liang1, O. E. Beaird1, S. Bunnapradist3, E. F. Reed2, S. Cole4

    1Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, 2Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, 3Division of Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, CA, 4Division of Hematology-Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA

    *Purpose: Changes in immune response are central to vulnerability to infection and rejection, especially for the growing numbers of older kidney transplant recipients. We sought…
  • 2019 American Transplant Congress

    Efficacy of Filgrastim in Solid Organ Transplant Recipients

    M. Spinner1, K. Gaffney1, S. Gundling2

    1Pharmacy, Cleveland Clinic, Cleveland, OH, 2University of Pittsburgh School of Pharmacy, Pittsburgh, PA

    *Purpose: Neutropenia frequently occurs after solid organ transplantation (SOT) due to immunosuppression, antiviral prophylaxis, or viral infections. Immunosuppression reduction or antiviral prophylaxis minimization can lead…
  • 2019 American Transplant Congress

    Evaluation of Induction Immunosuppression in Elderly Kidney Transplant Recipients

    C. Pham, S. Kuten, A. Rogers, R. Knight, D. T. Nguyen, E. Graviss, A. Gaber

    Houston Methodist Hospital, Houston, TX

    *Purpose: It is well recognized that elderly transplant recipients experience lower rates of acute rejection along with higher rates of infectious death compared to their…
  • 2019 American Transplant Congress

    Murine Cytomegalovirus Infection Down-Regulates Receptor Tyrosine Kinase MerTK on Macrophages to Abrogate Allograft Tolerance

    S. Yu, A. Dangi, M. Burnette, X. Luo

    Division of Nephrology, Department of Medicine, Duke Transplant Center, Duke University Medical Center, Durham, NC

    *Purpose: Cytomegalovirus (CMV) is one of the most common pathogens infecting solid organ transplant recipients. We recently showed that (1) CMV infection impairs the induction…
  • 2019 American Transplant Congress

    Identifying the Proverbial “Needle in the Arm” with Natural Language Processing

    G. R. Vece, J. Foutz, A. Placona

    Department of Research, United Network for Organ Sharing, Richmond, VA

    *Purpose: Donors with a history of IVDU are associated with increased disease transmission risk; However, OPTN forms only request broad historical details relating to donor…
  • 2019 American Transplant Congress

    Undernutrition is Associated with Impaired T Cell Protective Immunity in Pediatric Kidney Transplantation

    E. T. Chambers1, C. Chan1, R. Ettenger2, P. Grimm3, E. Reed2, M. Sarwal4, L. Stempora5, B. Warshaw6, C. Zhao1, O. Martinez7, A. Kirk5

    1Pediatrics, Duke University, Durham, NC, 2Pediatrics, UCLA, Los Angeles, CA, 3Pediatrics, Stanford, Palo Alto, CA, 4Pediatrics, UCSF, San Francisco, CA, 5Surgery, Duke University, Durham, NC, 6Pediatrics, Emory University, Atlanta, GA, 7Surgery, Stanford, Palo Alto, CA

    *Purpose: Undernutrition has been associated with T cell immune cell dysfunction and infectious complications in non-immunosuppressed children. Thus, we aimed to define T cell phenotypes…
  • 2019 American Transplant Congress

    More Advanced Heart Failure Prior To Transplant May Influence The Cytomegalovirus Specific T Cell Response In Cytomegalovirus Positive Recipients.

    U. López Cardoza, E. García, C. Díez, J. Roca, N. Sabé, N. Manito, I. Tatjer, A. Cequier, O. Bestard, J. González

    Bellvitge Universitary Hospital, L' Hospitalet de Llobregat, Spain

    *Purpose: Current assessment of risk of Cytomegalovirus (CMV) infection in CMV+ heart transplant (HT) recipients is poor. A diminished CMV-specific T cell response against 2…
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