Articles tagged "Infection"

2021 American Transplant Congress
The Gut Microbiota Diversity and Metabolite Production is Reduced in Liver Transplant Recipients and Associated with Post-Operative Infection
C. J. Lehmann, R. Keskey, R. Nayak, E. Littmann, E. Pamer, T. Baker
University of Chicago, Chicago, IL
*Purpose: Liver transplant (LT) recipients have abnormal microbiota before and after transplantation. (1,2) The association between fecal microbiota, metabolites, and clinical outcomes in liver transplantation…
2021 American Transplant Congress
Ganciclovir Therapeutic Drug Monitoring in Obese Adults Patients – Opportunity for Clinical Utility
Y. Tran¹, S. Bernard¹, R. W. Stevens¹, L. Myhre¹, R. Razonable²
¹Department of Pharmacy, Mayo Clinic, Rochester, MN, ²Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN
*Purpose: Ganciclovir (GCV) is the drug of choice for the treatment of cytomegalovirus (CMV) infection; optimal dosing of GCV in the obese patient population is…
2021 American Transplant Congress
Risk Factors Associated with Multidrug Resistant Organism (MDRO) Infections in Kidney Transplant Recipients: A Single Center Experience
S. Schrank¹, J. Timpone², B. Javaid³, P. Kumar², M. Cooper³
¹Internal Medicine, MedStar Georgetown University Hospital, Washington, DC, ²Infectious Diseases and Travel Medicine, MedStar Georgetown University Hospital, Washington, DC, ³Transplant Institute, MedStar Georgetown University Hospital, Washington, DC
*Purpose: Risk factors for MDRO infections in kidney transplant recipients have previously been studied but limited to urinary tract infections. We sought to evaluate the…
2021 American Transplant Congress
Longitudinal Studies of Blood Donor-derived Cell Free DNA (dd-cfDNA) Show Predictable Rise at Time of BK Viremia or Viruria in Pediatric Kidney Transplant Recipients (PKTx)
R. Dandamudi¹, H. Gu¹, C. Goss¹, S. Federman², R. Woodward², S. Dholakia², L. Walther¹, V. Dharnidharka¹
¹Washington University in St Louis, St. Louis, MO, ²CareDx, Brisbane, CA
*Purpose: Blood levels of dd-cfDNA elevate in various forms of kidney transplant injury, most notably used for detecting potential acute rejection. A few adult studies,…
2021 American Transplant Congress
COVID-19 Transmission within One Year from Pancreas and Kidney Recipients
H. Sarumi, J. Fisher, B. Johnson, T. Pruett
University of Minnesota, Minneapolis, MN
*Purpose: The current pandemic has created uncertainty surrounding the transmission of COVID-19. It was recently published that in the general population, household contacts have a…
2021 American Transplant Congress
Modification in Immunosuppression Regimens to Safely Perform Kidney Transplants Amid the Covid-19 Pandemic
L. Von Stein, O. Witkowsky, L. Samidurai, K. Flores, M. Doraiswamy, T. Pesavento, P. Singh
The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: In the USA, there was a 51.1% reduction in kidney transplant (KTx) since March 2020 due to concerns for contraction of COVID-19 in transplant…
2021 American Transplant Congress
Effect of HLA Class II Polymorphism on Predicted Cellular Immunity Against SARS-CoV-2 at the Individual Level and Within Twenty Five Race/ethnic Groups
H. C. Copley¹, L. Gragert², A. R. Leach³, V. Kosmoliaptsis¹
¹Department of Surgery, University of Cambridge, Cambridge, United Kingdom, ²Department of Pathology, Tulane University School of Medicine, New Orleans, LA, ³European Bioinformatics Institute (EMBL-EBI), Hinxton, United Kingdom
*Purpose: Development of adaptive immunity after COVID-19 and after vaccination against SARS-CoV-2 is predicated on recognition of viral peptides, presented on HLA class II molecules,…
2021 American Transplant Congress
Risk Factors and Outcomes of Neutropenia in Kidney Transplant Recipients
R. Avery¹, J. Motter¹, S. Sae-Tia², N. Lu¹, W. Cochran¹, A. Massie¹, D. Brennan¹, F. Akinwande¹, S. Shoham¹, E. Kraus¹, N. Alachkar¹, S. Alasfar¹, F. Naqvi¹, F. Al Ammary¹, K. Marr¹, S. Mehta Steinke¹, N. Desai¹, O. Ezennia¹, P. Plummer¹, C. Durand¹, W. Werbel¹, M. Y. Kim¹, D. Segev¹, J. Garonzik Wang¹, B. Trollinger¹, L. Lees¹, L. Toman¹, S. Shulder³, K. Dzintars¹, D. Ostrander¹
¹Johns Hopkins, Baltimore, MD, ²Stony Brook University, Stony Brook, NY, ³University of Rochester, Rochester, NY
*Purpose: Neutropenia is a common side effect of valganciclovir and may pose increased risk for post-transplant infections. Medications such as mycophenolate and infections such as…
2021 American Transplant Congress
COVID-19 in Hospitalized Kidney Transplant Recipients: Clinical Course, Prognostic Factors and Differences Between First and Second Waves
N. Macías, M. Rodríguez Ferrero, A. Acosta, J. Carbayo, Á. González Rojas, A. Muñoz de Morales, A. García Prieto, M. Goicoechea
Nephrology, Hospital Gregorio Marañón, Madrid, Spain
*Purpose: The aim was to describe the clinical course and management of SARS-CoV-2 infection in kidney transplant recipients (KTR) hospitalized with COVID-19, identify risk factors…
2021 American Transplant Congress
Variation of Mortality from SARS-CoV-2 Infection in Kidney Transplant Recipients Over the Course of the Pandemic
Y. Al Azzi, C. Pynadath, P. Loarte, O. Alani, L. Liriano-Ward, M. Ajaimy, R. Bartash, J. Graham, M. Le, H. Yaffe, S. Greenstein, J. Rocca, M. Kinkhabwala, E. Akalin
Montefiore Medical Center, New York, NY
*Purpose: We aimed to investigate the mortality from SARS-CoV-2 in kidney transplant recipients in the Bronx, New York, one of the epicenters of the pandemic…