2022 American Transplant Congress
Immunoglobulin M (IgM) Inhibits Replication of SARS-CoV-2 In Vero E6 Cells In Vitro and Delays Disease in K18-hACE2 Mice Infected with SARSCoV-2 In Vivo
*Purpose: To determine if IgM has a direct effect in preventing SARS-CoV-2 replication in Vero E6 cells, and delaying or preventing disease in infected K18-hACE2…2022 American Transplant Congress
Analysis of Sars-Cov-2-Specific T-Cell Responses Using Novel Single-Cell Multiplexed Isolight in Covid-19 Convalescents
1Northwestern University, Chicago, IL, 2IsoPlexis, Branford, CT
*Purpose: COVID-19 has poor outcomes in transplant recipients with reduced antibody responses. However, the exact cellular immune response against SARS-CoV-2 remains largely unclear. We developed…2022 American Transplant Congress
Effect of Sars-CoV-2 Delta Variant on Post-Vaccination COVID-19 Infection in Solid Organ Transplant Recipients
*Purpose: In July 2021, the SARS-CoV-2 Delta variant emerged as the dominant strain in the North Texas area. We reviewed COVID-19 infections post-vaccination in Solid Organ…2021 American Transplant Congress
Early Detection of SARS-CoV-2 and Other Infections in Solid Organ Transplant Recipients and Household Members Using Wearable Devices
*Purpose: Wearable devices that measure physiological parameters have shown utility for detecting infections such as influenza and recently COVID-19 up to 10 days before clinical…2021 American Transplant Congress
Lung Transplant Recipients with Severe Acute Respiratory Syndrome-Coronavirus 2 Infection and Asymptomatic Carriers Waiting for Lung Transplantation Induce Circulating Exosomes with Severe Acute Respiratory Syndrome-Coronavirus 2 Spike Protein S2
St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Exosomes are vesicles released by cells into body fluids. We demonstrated increased circulating exosomes with lung self-antigens (Collagen V, Kα1 Tubulin) and viral antigens…2021 American Transplant Congress
Dysregulation of Immune Cell Glycolysis and Oxidative Phosphorylation Correlates with Development of Pre-liver Transplant Immune Dysfunction and Post-transplant Mortality
*Purpose: Cirrhosis-related immune dysfunction contributes to early morbidity and mortality following liver transplant (LT). We have previously identified a pre-LT biomarker panel, the immune frailty…2021 American Transplant Congress
Relationship Between Tacrolimus Blood Levels and Covid-19 Pandemic in Kidney Transplant Recipients
*Purpose: The novel coronavirus 2019 infection (COVID-19) caused a pandemic, prompting Tokyo, Japan, to restrict on the free movement of people in March 2020. Kidney…2021 American Transplant Congress
Covid-19 Caseload and Management Practices Vary by Program-Level Factors: A Multinational Survey Study
1McGill University, Montreal, QC, Canada, 2Johns Hopkins University, Baltimore, MD
*Purpose: During the pandemic, the COVID-19 patient caseload (CPC) is thought to be highly variable and likely dependant on the cumulative COVID-19 incidence (CCI) of…2021 American Transplant Congress
Infectious Complications and Malignancy After Kidney Transplantation in the Elderly Population
Montefiore Medical Center, New York, NY
*Purpose: All patients, regardless of age, may benefit from renal transplantation due to improved quality of life and decreased mortality. However, elderly patients are at…2021 American Transplant Congress
The Impact of Fixed-Dose Alemtuzumab in Renal Transplant Recipients According to Weight
*Purpose: Alemtuzumab, a potent anti-CD52 monoclonal antibody is used for induction immunosuppression post-renal transplantation as a fixed 30mg dose regardless of the patient’s weight. The…
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