Articles tagged "Infection"

2022 American Transplant Congress
Outcomes of SARS-CoV-2 Infection in Unvaccinated Compared with One or Two Dose Vaccinated Solid Organ Transplant Recipients: A Multicenter, Matched Cohort Study
V. G. Hall¹, G. Alahmadi², J. T. Solera², T. Marinelli², H. Cardinal³, G. Ramesh Prasad⁴, S. A. De Serres⁵, D. Isaac⁶, R. Mainra⁷, C. Lamarche⁸, R. Sapir-Pichhadze⁹, S. Gilmour¹⁰, J. Matelski², A. Humar², D. Kumar²
¹University Health Network/Toronto General Hospital, Toronto, ON, Canada, ²UHN, Toronto, ON, Canada, ³Department of Medicine, UMontreal, Montreal, QC, Canada, ⁴Kidney Transplant Program, St. Michael's Hospital, Toronto, ON, Canada, ⁵Transplantation Unit, Renal division, Laval University, Quebec, QC, Canada, ⁶Division of Transplant Medicine, University of Calgary, Calgary, AB, Canada, ⁷University Health Center of Saskatchewan, Saskatoon, SK, Canada, ⁸Hôpital Maisonneuve-Rosemont Research Institute, Montreal, QC, Canada, ⁹McGill University, Montreal, QC, Canada, ¹⁰Stollery Children's Hospital, Edmonton, AB, Canada
*Purpose: It is unknown if vaccine breakthrough COVID-19 infections are milder or as severe as infections in unvaccinated solid organ transplant (SOT) recipients.*Methods: We performed…
2022 American Transplant Congress
Detection of Microbiota from Catheter Tip in Hemodialysis Patients During the Perioperative Period of Kidney Transplantation Based on Metagenomics: A Prospective Study
Z. Yan, Y. Wang, W. Zeng, R. Xia, W. Deng, J. Xu, Y. Miao
Department of Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou, China
*Purpose: Catheter-related infection (CRI) is the most serious complication in dialysis patients. However, current studies are limited to routine culture or immunological examination of CRI.…
2022 American Transplant Congress
Early Tacrolimus Exposure is Associated with BK-Viremia in Kidney Transplant Recipients
S. Meziyerh, A. L. van Rijn, D. van der Helm, P. J. van der Boog, T. van Gelder, A. C. Kroes, J. W. de Fijter, D. J. Moes, J. I. Rotmans, M. C. Feltkamp, A. P. de Vries
LUMC, Leiden, Netherlands
*Purpose: There is scant evidence to what extent maintenance immunosuppression is quantitatively associated with BK viremia. We investigated the association between tacrolimus (tac) whole blood…
2022 American Transplant Congress
Leflunomide in Children with BK Polyomavirus Viremia After Kidney Transplant
J. Hewlett¹, K. Le Palma¹, L. Galea¹, J. Savant¹, S. Lopez¹, J. V. Rosano², A. Strong¹, B. Viteri¹, C. LaRosa¹, S. Amaral¹, B. Laskin¹
¹The Children's Hospital of Philadelphia, Philadelphia, PA, ²Yale New Haven Health, New Haven, CT
*Purpose: Studies examining the use of leflunomide in treating BK polyomavirus (BKPyV) viremia in children after kidney transplant are limited to case reports with small…
2022 American Transplant Congress
Longitudinal Characterization of the Microvirome in a Cohort of Renal Transplant Recipients
A. C. Johnson, G. Karadkhele, C. P. Larsen
Emory University, Atlanta, GA
*Purpose: The selective targeting of T cells in transplant immunosuppression medications leads to a high rate of viral infections, with different immunosuppression regimens resulting in…
2022 American Transplant Congress
Outcomes in Hepatitis C (HCV) Viremic Grafts to HCV Negative Recipients in Heart Transplantation: A Multicenter Study of Differing Treatment Strategies
K. Ryland¹, B. Aqel², D. Steidley², P. Patel¹, S. Pungpapong³
¹Mayo Clinic, Jacksonville, FL, ²Mayo Clinic, Phoenix, AZ, ³Mayo Clinic College of Medicine, Jacksonville, FL
*Purpose: Using HCV viremic grafts for heart transplantation (HT) improves donor supply and shortens wait times. However, treatment strategies are variable post-transplant. This study aims…
2022 American Transplant Congress
Impact of HMGB-1 SNPs on Comorbidities and Postoperative Complications in Liver Transplant Recipients
N. Tsukiyama¹, Y. Tanaka¹, Y. Imaoka¹, A. Seidakhmetov¹, R. Nakano¹, N. Tanimine¹, D. Marlen¹, M. Ohira², H. Tahara¹, K. Ide¹, H. Ohdan¹
¹Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan, ²Hiroshima University, Hiroshima, Japan
*Purpose: High-mobility group box 1 (HMGB-1) is an inflammatory mediator which becomes an uncontrollable lethal factor when released in excess from the nucleus or the…
2022 American Transplant Congress
Immunosuppressant Medications Use in Patients with Transplant Failure: A Canadian Multi-Centre Prospective Study
G. Knoll¹, M. Chassé², D. Fergusson³, A. A. House⁴, O. Johnston⁵, R. Mainra⁶, D. Baran⁷, D. Treleaven⁸, l. senecal⁹, L. Tibbles¹⁰, M. Hebert¹¹, M. Karpinski¹², T. Campbell¹³, T. Ramsay¹⁴, J. Kim¹⁵, I. Houde¹⁶, C. White¹⁷, J. Perl¹⁵, P. Karnabi¹⁸, J. Gill⁵
¹Nephrology, Ottawa Hospital Research Institute, Ottawa, ON, Canada, ²University of Montreal, Montreal, QC, Canada, ³Ottawa Hospital Research Institute, Ottawa, ON, Canada, ⁴Nephrology, Western University, London, ON, Canada, ⁵Nephrology, University of British Columbia, Vancouver, BC, Canada, ⁶Nephrology, University of Saskatchewan, Saskatoon, SK, Canada, ⁷Nephrology, McGill University, Montreal, QC, Canada, ⁸Nephrology, McMaster University, Hamilton, ON, Canada, ⁹Nephrology, Maisonneuve-Rosemont Hospital, Montreal, QC, Canada, ¹⁰Nephrology, University of Calgary, Calgary, AB, Canada, ¹¹Nephrology, University of Montreal, Montreal, QC, Canada, ¹²Nephrology, University of Manitoba, Winnipeg, MB, Canada, ¹³University of Alberta, Alberta, AB, Canada, ¹⁴Ottawa Hospital Research Institute, Ottawa, ON, Canada, ¹⁵University of Toronto, Toronto, ON, Canada, ¹⁶Laval University, Que´bec, QC, Canada, ¹⁷Queen's University, Kingston, ON, Canada, ¹⁸Ottawa Health Research Institute, Ottawa, ON, Canada
*Purpose: This prospective study determined the association of immunosuppressant medication use with the outcomes of death, hospitalized infection, rejection of the failed allograft, and panel…
2022 American Transplant Congress
Preoperative Antibiotics Administration is Important to Prevent Hand Port-Site Infection After Hand-Assisted Laparoscopic Donor Nephrectomy for Living-Donor Kidney Transplantation
T. Hiramitsu, T. Tomosugi, K. Futamura, M. Okada, N. Goto, T. Ichimori, S. Narumi, Y. Watarai
Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan
*Purpose: Due to the profound organ shortage, the number of living donor kidney transplantation (LDKT) is increasing. Hand-assisted laparoscopic donor nephrectomy (HALDN) is widely performed…
2022 American Transplant Congress
Differences in Strength and Longevity of SARS-CoV-2-Specific Adaptive Immunity Between Convalescent and Vaccinated SOT Patients and Immunocompetent Individuals
L. Donadeu¹, S. Gomez¹, A. Fava'², E. Crespo¹, F. Moreso³, M. Lopez³, L. Lladó⁴, J. González⁴, I. Campos³, M. Muñoz³, J. Quintero³, J. Esperalba³, O. Bestard³
¹Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, ²Bellvitge University Hospital, L'Hospitalet de Llobregat. Barcelona, Spain, ³Vall d’Hebron University Hospital (HUVH), Barcelona, Spain, ⁴Bellvitge University Hospital, L'Hospitalet de Llobregat, Spain
*Purpose: Short-term adaptive immune memory has been reported among immunocompetent (IC) and convalescent Solid Organ Transplant (SOT) individuals following SARS-CoV-2 infection as well as after…