ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Indirect pathway"

  • 2022 American Transplant Congress

    CD14+ Monocytes Play a Critical Role in Initiating Xeno-Recognition, Costimulation and Immune-Responses to Porcine Endothelial Cells

    H. Xu, A. Kirk, H. Xu

    Duke University School of Medicine, Durham, NC

    *Purpose: Porcine endothelial cells (PECs) are the first barrier between a pig’s organ and circulating immune system. Unlike allogeneic immune responses, PECs fail to induce…
  • 2022 American Transplant Congress

    Validation of Shared T Cell Epitope Analysis as a Tool to Detect Preformed Donor-Reactive CD4+ Memory T-helper Cells

    T. Tomosugi1, K. Iwasaki2, S. Sakamoto3, K. Ftamura1, M. Okada1, T. Hiramitsu1, N. Goto1, S. Narumi1, Y. Watarai1, T. Kobayashi4

    1Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan, 2Department of Kidney Diseases and Transplant Immunology, Aichi Medical University School of Medicine, Nagoya, Japan, 3Histocompatibility Laboratory, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan, 4Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Japan

    *Purpose: Adaptive immunity creates immunological memory after the first response to a specific foreign antigen including HLA. During this response, adaptive immunity memorizes the molecular…
  • 2020 American Transplant Congress

    Clinical Significance of T Cell and B Cell Epitope Prediction as a Risk Factor of De Novo DSA Production after Kidney Transplantation

    T. Kobayashi1, K. Iwasaki1, T. Tomosugi2, Y. Miwa1, M. Niemann3, E. Spierings4, K. Horimi1, Y. Matsuoka1, A. Takeda2, N. Goto2, S. Narumi2, Y. Watarai2

    1Aichi Medical University School of Medicine, Nagakute, Japan, 2Nagoya Daini Red Cross Hospital, Nagoya, Japan, 3PIRCHE AG, Berlin, Germany, 4UMC Utrecht, Utrecht, Netherlands

    *Purpose: Chronic antibody-mediated rejection caused by de novo DSA (dnDSA) is a major cause of graft failure. Risk prediction of dnDSA would be important for…
  • 2020 American Transplant Congress

    Gal9/Tim-3 Pathway was Required for Endometrial Stem Cells to Induce Peripheral Tolerance of Cardiac Allograft

    Y. Zhao1, Y. Hu1, D. Yu1, X. Li1, W. Jin1, Y. Qin1, D. Kong1, H. Wang1, A. Alessandrini2, H. Wang1

    1Tianjin Medical University General Hospital, Tianjin, China, 2Massachusetts General Hospital, Boston, MA

    *Purpose: The existing immunosuppressants seem to have little effect on Cardiac Allograft Vasculopathy but with obvious side effects. ERCs (Endometrial stem Cells), which are mesenchymal-like…
  • 2019 American Transplant Congress

    Tacrolimus Activated BMP Signaling Acts in Synergy with Stress-Activated FOXO1 to Induce Loss of Beta-Cell Function and Identity

    J. Trinañes1, P. ten Dijke2, T. J. Rabelink3, E. J. de Koning4, F. Carlotti1, A. P. de Vries1

    1Transplant Center, Leiden University Medical Center, Leiden, Netherlands, 2Molecular Cell Biology, Leiden University Medical Center, Leiden, Netherlands, 3of Nephrology, Leiden University Medical Center, Leiden, Netherlands, 4Nephrology, Leiden University Medical Center, Leiden, Netherlands

    *Purpose: Tacrolimus, the most widely used immunosuppressive drug, is known to be highly diabetogenic. It is thought to trigger β-cell death through inhibition of the…
  • 2018 American Transplant Congress

    Allogeneic T Follicular and T Conventional Responses Assessed by Proliferation, Cytokine Production, and TCR Clonality

    C. Macedo,1 M. Yamada,1 X. Gu,1 M. Suchoroski,2 D. Hamm,2 M. Kaplan,2 D. Metes.1

    1Thomas E. Starzl Transplantation Institute, Pittsburgh; 2Adaptive Biotechnologies, Seattle.

    Background: Human CD4+ T cell allo-immunity plays pivotal roles during cellular and humoral allograft rejection. Our previous analysis showed that allo-reactive precursors were present in…
  • 2016 American Transplant Congress

    Indirect Allo-Antigen Stimulation Identifies the Presence of Either Regulatory IL-10 or of Effector Cytokines IFN-g, IL-21, IL-17a Production by Human Blood Allo-Reactive Memory TFH and TCONV CD4+ T Cells.

    C. Macedo, F. Paul, Y. Masaki, H. Kevin, M. Diana.

    Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA.

    Background: It is well accepted that human CD4+ T cell allo-immunity plays pivotal roles during cellular and humoral allograft rejection. While our previous analysis showed…
  • 2015 American Transplant Congress

    Dramatic Primary Expansion of Indirect CD4 T Cells to Allogeneic APCs In Vivo

    N. Bishop,1 M. Nelsen,1 M. Coulombe,2 R. Gill.2

    1Immunology, University of Colorado Denver, Aurora, CO; 2Surgery, University of Colorado Denver, Aurora, CO.

    An ongoing question regarding the primary allograft response is the relative contribution of the 'direct' (donor MHC-restricted) versus 'indirect' (host MHC-restricted) pathways of T cell…
  • 2015 American Transplant Congress

    Effective Control of Anti-Xenogeneic IL-17 Response for Tolerance Induction in Xenogeneic Islet Cell Transplantation

    H. Kang,1 S. Wang,1,2 X. Zhang,3 L. Zhang,1 S. Miller,4 B. Hering,5 X. Luo.1,3,4

    1Medicine, Northwestern University Feinberg school of Medicine, Chicago, IL; 2Tianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, China; 3Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL; 4Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL; 5Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN.

    We have previously shown that peri-transplant infusion of donor cells treated with 1-ethyl-3-(3'-dimethylaminopropyl)-carbodiimide (ECDI) in combination with peri-transplant anti-CD20 and rapamycin induce permanent porcine islet…
  • 2015 American Transplant Congress

    IgM+ Antigen Binding B Cells in Peripheral Blood Regulate IFNγ Production in Response to HLA Proteins

    L. McLaughlin,1 K. Shiu,1 G. Lombardi,1 J. Spencer,2 R. Vaughan,1 A. Dorling.1

    1MRC Centre for Transplantation, King's College London, London, United Kingdom; 2Peter Gorer Department of Immunobiology, King's College London, London, United Kingdom.

    Chronic antibody mediated rejection (CAMR) is a major cause of graft loss in renal transplant recipients. Previous work utilising an IFNγ ELISPOT assay revealed two…

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