ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunosuppression"

  • 2017 American Transplant Congress

    Allograft Cytokine Activation and Elevated Tissue Indoleamine 2,3-Dioxygenase Gene and Protein Expression in Rejecting Pig Transplants.

    T. Merchen,1 Y. Wang,2 R. Lassiter,1 D. Kleven,3 R. Jajosky,3 M. Winn,2 C.-S. Ho,5 N. Nahman.4

    1Surgery, MCG at Augusta University, Augusta, GA; 2Medicine, MCG at Augusta University, Augusta, GA; 3Pathology, MCG at Augusta University, Augusta, GA; 4Norwood VAMC, Augusta, GA; 5Gift of Life Michigan, Ann Arbor, MI

    Viral delivery of the indoleamine 2,3-dioxygenase (IDO) transgene results in transprotein synthesis and mitigates rejection in rodent kidney transplants (J Gene Med 13:373); but in…
  • 2017 American Transplant Congress

    Understanding the Role of Induction Agents in Older versus Younger Kidney Transplant Recipients.

    Q. Huang, F. Ammary, M. McAdams-DeMarco, D. Segev.

    Johns Hopkins University, Baltimore, MD

    Background: There has been an increase in the number of older (over 65) KT recipients. Aging-related changes such as differences in immune senescence may influence…
  • 2017 American Transplant Congress

    Photopheresis for Recalcitrant Rejection After Heart Transplantation: Worthwhile?

    J. Patel, M. Kittleson, X. Zhang, E. Klapper, T. Aintablian, K. Murayama, L. Czer, D. Geft, D. Chang, J. Kobashigawa.

    Cedars-Sinai Heart Institute, Los Angeles

    Background: Rejection is leading cause of mortality after heart transplantation (HTx). While the rates of rejection have declined over the past few decades from improvement…
  • 2017 American Transplant Congress

    Soluble Fibrinogen-Like Protein 2 Regulates Differentiation and Enhances Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Allograft Immunity.

    C. Yang, B. Peng, M. Xu, T. Zhu.

    Urology, Zhongshan Hospital, Fudan University, Shanghai, China

    Soluble fibrinogen-like protein 2 (sFGL2) is a novel immunoregulatory molecule, secreted mainly by regulatory T cells. CD11b+ Gr1+ myeloid-derived suppressor cells (MDSCs) are an important…
  • 2017 American Transplant Congress

    Pre Transplant Donor Specific Antibodies and Clinical Outcomes in Kidney Transplant Recipient on Steroid Free Maintenance Immunosupression Regimen.

    O. Adebiyi,1 A. Sharfuddin,2 M. Yaqub,1 S. Hussain,1 D. Mishler,1 A. Sharfuddin,1 W. Goggins,1 T. Taber.1

    1Renal Transplant, Indiana University School of Medicine, Indianapolis, IN; 2Internal Medicine, Baqai University Hospital, Karachi, Pakistan

    Background: The clinical relevance of pre transplant donor specific antibodies has been reported in few clinical studies with respect to its effect on the risk…
  • 2017 American Transplant Congress

    Effect of Everolimus on the Cardiac Function in Kidney Transplant Recipients.

    K. Tsujimura,1 M. Ota,1 H. Ishida,2 K. Tanabe.2

    1Surgery, Tomishiro Central Hospital, Tomishiro-shi, Okinawa, Japan; 2Urology, Kidney Center, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan

    PURPOSE: In this study, we evaluated the effect of everolimus (EVR), one of the mammalian targets of rapamycin on cardiac function in kidney transplant recipients.METHODS:We…
  • 2017 American Transplant Congress

    mTOR Inhibitor and Low-Dose Tacrolimus in Pediatric Kidney Transplant (PKT): 9-Years Data of a Bi-Therapy Treatment.

    R. Vilalta, E. Lara, A. Madrid, M. Muñoz, S. Chocron, G. Ariceta.

    Pediatric Nephrology, Hosptal Vall d´Hebron, Barcelona, Spain

    INTRODUCTIONNephrotoxicity , serious infectious, or malignancy risk , curtails tacrolimus use in PKT . However, based on potential antiviral and antitumoral actions of mTOR inhibitor…
  • 2017 American Transplant Congress

    Tacrolimus Intra-Patient Variability Determined from Daily Trough Levels in Adherent Kidney and Liver Transplant Recipients.

    A. Leino,1 T. Kaiser,1 Y. Zou,2 E. King,2 A. Vinks,2 W. Jiang,4 U. Christians,3 E. Woodle,1 R. Alloway.1

    1University of Cincinnati, Cincinnati; 2Cincinnati Children's Hospital, Cincinnati; 3University of Colorado, Denver; 4Food and Drug Administration, Silver Spring

    Drugs are classified as highly variable when intra-patient coefficient of variation (CV%) is > 30%. Tacrolimus (TAC) is characterized as highly variable often without supporting…
  • 2017 American Transplant Congress

    High Mortality in Transplant Recipients Associated with Coccidioidomycosis Derived from Organ Donors.

    N. Jeyakumar,2 N. Neidlinger,3 M. Salvatore,3 C. Brown,4 T. Carpenter,3 M. Fung,1 P. Chin-Hong.1

    1Department of Medicine, University of California, San Francisco, San Francisco, CA; 2Department of Medicine, University of Miami Miller School of Medicine, Miami, FL; 3Donor Network West, San Ramon, CA; 4Decision Patterns, Oakland, CA

    Purpose Coccidioidomycosis (CI) occurs in 4-9% of solid organ recipients in endemic areas, resulting in 30-63% mortality. CI can be transmitted directly via transplantation, but…
  • 2017 American Transplant Congress

    Stability of Immune Phenotype, Alloreactive, and Antiviral Immunity After Switch to Belatacept-Based Regimen After Kidney Transplantation.

    J. Schaenman, M. Rosetti, T. Sidwell, V. Groysberg, G. Sunga, E. Liang, J. Gadzhyan, B. Abdalla, E. Lum, T. Pham, G. Dannovitch, J. Veale, H. Gritsch, E. Reed, S. Bunnapradist.

    David Geffen School of Medicine at UCLA, Los Angeles, CA

    Purpose: This investigator-initiated study examines the impact of belatacept on T cell immune phenotype and function.Methods: 14 patients who had completed the study protocol were…
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