Articles tagged "Immunosuppression"

2017 American Transplant Congress
Pre-Transplant Panel Reactive T Cells (PRT) with IL-15 as a Risk-Stratifier of Acute Rejection in Kidney Transplant Patients on Belatacept Therapy.
P. Cravedi,¹ I. Gandolfini,¹ C. Donadei,¹ R. Fairchild,² K. Newell,³ R. Mannon,⁴ P. Heeger,¹ CTOT16 Consortium.
¹Dept of Medicine, Icahn School of Medicine at Mount Sinai, New York; ²Dept of Immunology, Cleveland Clinic, Cleveland; ³Dept of Surgery, Emory University, Atlanta; ⁴Renal Division, UAB, Birmingham
While kidney transplant recipients treated with bela without calcineurin inhibitors (CNI) have better 5-10y eGFR versus those on CNI, Belatacept (bela) use is associated with…
2017 American Transplant Congress
Rapamycin Maintenance Therapy in Pediatric Liver Transplant Recipients Associated with Trend Toward Decreasing Th2 Cytokine Levels Compared to Tacrolimus Therapy.
R. Fischer,¹ A. Seng,² L. Gardner,² L. Steele,² L. Harvey,¹ H. Wasserkrug,¹ W. Andrews,¹ R. Hendrickson,¹ J. Daniel,¹ T. Yankee.²
¹Children's Mercy Hospital, Kansas City, MO; ²University of Kansas Medical Center, Kansas City, KS
Background: Maintenance immunosuppression after liver transplantation with tacrolimus (TAC) may have progressive fibrosis on serial allograft biopsies. mTOR inhibitors such as rapamycin (RAPA) may abrogate…
2017 American Transplant Congress
Emerging Application of Active Immune Targeted Delivery in Transplantation.
M. Uehara,¹ J. Azzi,¹ B. Bahmani,^1,2 J. Cheng,³ Q. Yin,³ L. Tang,³ K. Cai,³ Q. Sun,³ M. Kwon,³ Q. Xu,² G. Brandacher,⁴ R. Abdi.¹
¹Transplantation Research Center/Renal Devision, Brigham and Women's Hospital, Boston; ²Department of Biomedical Engineering, Tufts University, Boston; ³Department of Materials Science and Engineering, University of Illinois at Urbana Champaingn, IL; ⁴Plastic and Reconstructive Surgery, Johns Hopkins Medicine, Baltimore
The homing of naïve lymphocytes to the lymph node (LN) is fundamental to the priming of alloreactive T cells. LNs possess highly restricted high endothelial…
2017 American Transplant Congress
Tracking the In Vitro Phenotype and Proliferative Capacity of CD57+ CD4 T Cells.
J. Espinosa,¹ J. Lockley,¹ F. Shaw,¹ R. Osborne,¹ M. Joshi,¹ T. Woody,¹ M. Ellis,¹ B. Hollister,¹ J. Cheeseman,¹ R. Townsend,² A. Kirk.¹
¹Duke University, Durham; ²Bristol-Meyers Squibb, Princeton
CD57+PD1- CD4 T cells are primed effectors with increased expression of adhesion molecules capable of infiltrating allografts and mediating belatacept-resistant rejection (BRR). Whether CD57 is…
2017 American Transplant Congress
Outcomes with Steroid Avoidance Regimen After Kidney Transplantation without Induction Immunosuppression.
A. Sakhuja,¹ A. Naik,² D. Cibrik,² H. Amer.³
¹Medicine - Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN; ²Internal Medicine - Nephrology, University of Michigan, Ann Arbor, MI; ³Medicine - Nephrology and Hypertension, Mayo Clinic, Rochester, MN
INTRODUCTION: Use of induction immunosuppression therapy at the time of kidney transplantation is variable in low immunological risk kidney transplant recipients. Though acceptable allograft outcomes…
2017 American Transplant Congress
Naïve and Interferon-gamma Activated Mesenchymal Stem Cells Differentially Affect Immune Responses In Vitro and In Vivo.
R. Patil,¹ K. Premanand,¹ L. Halliday,¹ E. Szilagyi,¹ M. Willman,² J. Yu,¹ R. Hickey,¹ D. Berman,² A. Antony,¹ F. Pan,¹ X. Wang,¹ K. McHenry,⁴ D. Salomon,³ N. Kenyon,² A. Bartholomew.¹
¹University of Illinois, Chicago; ²University of Miami, Miami; ³University of Illinois, Urbana-Champaign; ⁴The Scripps Research Institute, La Jolla
We have observed interferon gamma-treated autologous mesenchymal stem cells (MSC) to rapidly ex vivo expand CD3+CD4+CD25- T cells to >80% CD3+CD4+C25+FoxP3+ T regulatory cells with…
2017 American Transplant Congress
Assessment of a Medication Education Program Among New Transplant Recipients at a Large Academic Health Center.
G. Meadows,¹ J. Kyle,¹ A. Dodson,¹ K. Gutierrez,¹ P. MacLennan,² F. Iqbal,² L. Weldon,¹ D. Jones,¹ A. James.¹
¹Department of Pharmacy, University of Alabama at Birmingham Hospital, Birmingham, AL; ²Division of Transplantation, University of Alabama at Birmingham, Birmingham, AL
To help patients understand their medications and for adjustment post-transplant, we have implemented a self-medication (self-meds) program as a method of teaching patients their medications…
2017 American Transplant Congress
Risk Factors for Cryptococcal Disease in Transplant as Compared with Non-Transplant Patients: A Single Center Study.
O. Beaird,¹ O. Garner,² R. Humphries,² J. Schaenman.¹
¹David Geffen School of Medicine at UCLA, Los Angeles, CA; ²UCLA Pathology & Laboratory Medicine, Los Angeles, CA
Purpose: To examine clinical characteristics of non-HIV, immunocompromised patients diagnosed with cryptococcal disease, including solid-organ transplant (SOT) recipients.Methods: We performed retrospective chart review of non-HIV,…
2017 American Transplant Congress
Long-Term Follow-Up of the Safety and Effects of Bariatric Surgery on Immunosuppression in Post-Transplant Patients.
A. Keidar,¹ R. Yemini,¹ I. Carmeli,¹ E. Nesher,² J. Vinkler,² E. Mor,² M. Bendavid.¹
¹Surgery, Beilinson Hospital, Tel Aviv, Israel; ²Transplantation, Beilinson Hospital, Tel Aviv, Israel
Objectives: To report the safety and feasibility of maintaining immunosuppression and graft safety after bariatric surgery among solid organ transplanted patients.Summary Background Data: Transplanted patients…
2017 American Transplant Congress
NFAT-Regulated Cytokine Gene Expression for Immune Monitoring in Kidney Transplant Recipients – A Randomized Controlled Trial.
A. Webber,¹ V. Tatapudi,² C. Leung,³ F. Vincenti.^1,3
¹Division of Nephrology, UCSF, San Francisco, CA; ²Division of Nephrology, NYUMC, New York, NY; ³Surgery, UCSF, San Francisco, CA
Purpose: To demonstrate that a pharmacodynamics assay using Real Time (RT)-PCR to measure residual expression (RE) of nuclear factor of activated T cell (NFAT)-dependent cytokines…