Articles tagged "Immunosuppression"

2017 American Transplant Congress
Cyclosporine Effects on Blood Pressure Are Exaggerated in Pubertal Girls After Renal Transplantation.
A. Melk,¹ R. Sugianto,¹ B. Schmidt,² K. Krupka,³ B. Höcker,³ B. Tönshoff,³ E. Wühl.³
¹Pediatric Nephrology, Hannover Medical School, Hanover, Germany; ²Nephrology, Hannover Medical School, Hanover, Germany; ³Pediatric Nephrology, University of Heidelberg, Heidelberg, Germany
Hypertension is a common problem after renal transplantation. We investigated potential contributing factors for high blood pressure (BP) in 336 pediatric transplant recipients from the…
2017 American Transplant Congress
Graft-versus-Host Disease Following Deceased Donor Liver Transplant.
K. Putchakayala, S. Skorupski, S. Farhan, M. Chaffins, S. Ilias, H. Pahari, K. Collins, S. Nagai, M. Abouljoud.
Henry Ford Hospital, Detroit, MI
We reviewed our institutional experience with graft-versus-host disease (GVHD) following orthotopic liver transplantation (OLT). All OLT from 10/1/2013-10/1/2016 were reviewed. Five cases of GVHD were…
2017 American Transplant Congress
Tacrolimus Time in Therapeutic Range Predicts Adverse Clinical Outcomes in the First Year of Kidney Transplant.
S. Davis, J. Gralla, P. Klem, A. Wiseman, J. Cooper.
University of Colorado, Aurora, CO
Tacrolimus (TAC) has a narrow therapeutic range, with its upper bounds limited by serious toxicities while TAC minimization strategies have demonstrated immunologic risk. Monitoring the…
2017 American Transplant Congress
Differential Effects of the Novel ATP-Competitive mTOR Inhibitor (TORKinib) AZD2014 and Rapamycin on Alloimmunity and Transplant Survival.
D. Fantus, Y. Ono, H. Dai, S. Yokota, O. Yoshida, A. Thomson.
Surgery, Thomas Starzl Transplantation Institute, Pittsburgh, PA
Background: Rapamycin (RAPA), is an immunosuppressive agent that inhibits the mechanistic target of Rapamycin (mTOR), the kinase subunit of two mTOR- containing complexes (mTORC1 and…
2017 American Transplant Congress
Inhibition of Liver Natural Killer Cells Activation Through Co-Transplantation of Pre-Activated Mesenchymal Stem Cells Contributes to Improvement of Islet Graft Survival.
N. Ishida, K. Ishiyama, Y. Saeki, Y. Tanaka, H. Ohdan.
Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
Introduction: We have previously reported that enhancement of TNF-related apoptosis-inducing ligand (TRAIL)-mediated liver NK-cell activity after intraportal islet transplantation (IT) inhibits engraftment of islets. Recently,…
2017 American Transplant Congress
Kidney-Specific Immunosuppression without Adverse Systemic Effects.
D. Kentrup,¹ K. Schuette-Nuetgen,¹ H. Pawelski,¹ H. Pavenstädt,¹ S. Hermann,² M. Schaefers,² G. Larbig,³ A. Kuebelbeck,³ S. Reuter.¹
¹Department of Medicine D, University Hospital Muenster, Muenster, Germany; ²European Institute for Molecular Imaging - EIMI, University Hospital Muenster, Muenster, Germany; ³Merck KGaA, Darmstadt, Germany
Purpose: Immunosuppressive therapy is often accompanied by severe adverse effects. To overcome this, the aim of this study was the evaluation of a kidney-specific drug…
2017 American Transplant Congress
Emerging Variables Which May Enhance Care of HIV Positive Renal Transplant Recipients.
D. Leonard, M. Prendergast.
Transplantation, Mayo Clinic, Jacksonville, FL
Purpose: Single center experience of kidney and pancreas transplantation in the HIV positive populationMethods: Retrospective data and outcomes analysis of HIV positive kidney and pancreas…
2017 American Transplant Congress
Treatment of Post-Transplant Nephrotic Syndrome with Adrenocorticotropic (ACTH) Gel.
A. Khalil,² A. Karabala,¹ A. Sharfuddin,² M. Grafals.¹
¹Medstar Georgetown Transplant Institute, Washington DC; ²Indiana University Health, Indianapolis
Objectives: Post-kidney transplant proteinuria due to recurrent GN is considered to be a significant risk factor negatively affecting kidney transplant survival. In this case series…
2017 American Transplant Congress
CD4⁺/CD8⁺ T Cell Ratio as a Predictive Marker for Early Graft Failure in Pig to Non-Human Primate Islet Xenotransplantation with Immunosuppression.
S. Choi,^1,3,4 H.-J. Kim,^1,2,3,4 I.-H. Yoon,^1,2 J.-S. Kim,^1,2,6 S.-J. Kang,^1,2,3,4 H.-Y. Nam,^1,2 B.-H. Min,¹ J.-S. Shin,^1,6 J.-M. Kim,^1,6 Y.-H. Kim,^1,5 W.-W. Lee,^1,2,3,4 C.-G. Park.^1,2,3,4,6
¹Xenotransplantation Research Center, Seoul National University College of Medicine, Seoul, Korea; ²Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea; ³Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea; ⁴Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea; ⁵Department of Microbiology, Kyungpook National University School of Medicine, Daegu, Korea; ⁶Institute of Endemic Diseases, Seoul National University College of Medicine, Seoul, Korea
Background: Outstanding results from nonhuman primate study put islet xenotransplantation with immunosuppression closer to the clinical application. To establish successful immune suppressive protocols, immune monitoring…
2017 American Transplant Congress
Predictors of Malignancies Across Solid Organ Transplantation.
M. Bhat,¹ K. Mara,² R. Dierkhising,² K. Watt.³
¹Multi Organ Transplant Program, University Health Network, Toronto, ON, Canada; ²Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN; ³Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN
Background & Aims:Solid organ transplant recipients are at much higher risk of cancer as compared to the general population. The aim of this study was…