ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunosuppression"

  • 2017 American Transplant Congress

    Clinical Outcomes of Simplified Once-Daily Immunosuppressive Regimen for Stable Kidney Recipients.

    C.-K. Oh,1 S.-J. Kim,2 K. Huh,3 S. Kim,4 J. Jeon,5 S. Han,6 H. Cho,7 Y. Kwon,8 S. Lee,1 Y. Kim.3

    1Surgery, Ajou University School of Medicine, Suwon, Republic of Korea; 2Surgery, Samsung Medical Center, Seoul, Republic of Korea; 3Surgery, Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea; 4Surgery, CHA University School of Medicine, Kumi, Republic of Korea; 5Internal Medicine, Soon Chun Hyang University Hospital, Seoul, Republic of Korea; 6Internal Medicine, Ilsan Paik Hospital, Goyang, Republic of Korea; 7Surgery, Ulsan University Hospital, Ulsan, Republic of Korea; 8Internal Medicine, Korea University Guro Hospital, Seoul, Republic of Korea

    Aims. Many immunosuppressive drugs are prescribed as twice-daily dosing. Simplified once-daily dosing of the entire drug regimen can improve treatment satisfaction for patients. We examined…
  • 2017 American Transplant Congress

    A Single Center Retrospective Review of Pediatric Kidney Transplant Outcomes According to Banff Grade and Cellular Rejection Treatment.

    J. Chen,1 R. Liverman,2 R. Garro,2,3 S. Jernigan,2,3 P. Winterberg.2,3

    1Morgan Stanley Children's Hospital, New York, NY; 2Children's Healthcare of Atlanta, Atlanta, GA; 3Department of Pediatrics, Emory University, Atlanta, GA

    Acute cellular rejection (ACR) remains a major cause of graft dysfunction and loss. There is limited data to provide guidance on optimal treatment strategies stratified…
  • 2017 American Transplant Congress

    Novel Personalized Immune-Monitoring Assay for Predicting Operational Tolerance by Using Humanized Mouse Model.

    Y. Fukasaku,1 R. Goto,1 Y. Ganchiku,1 M. Zaitsu,1 M. Watanabe,1 N. Kawamura,1 Y. Koshizuka,1 K. Yamashita,2 T. Shimamura,3 A. Taketomi.1

    1Gastroenterological Surgery I, Hokkaido University, Sapporo, Japan; 2Transplant Surgery, Hokkaido University, Sapporo, Japan; 3Division of Organ Transplantation, Hokkaido University, Sapporo, Japan

    Background: Biomarkers and immune-monitoring assays predicting operational tolerance in transplant recipients have not been established. Our aim was to develop an immune-monitoring assay to address…
  • 2017 American Transplant Congress

    Impact of Bariatric Surgery on Risk of Organ Rejection Among Solid Organ Transplant Recipients.

    M. Soghikian, D. Gregory, J. Wilcox, A. Shetty, D. Ladner, L. VanWagner.

    Medicine, Northwestern University, Chicago, IL; Surgery, Northwestern University, Chicago, IL

    Background: Obesity is a common condition that contributes to organ failure. Bariatric surgery is an effective surgical therapy for obesity and has been performed both…
  • 2017 American Transplant Congress

    Belatacept Conversion for Calcineurin Inhibitor (CNI) Toxicity: Our First 100 Patients.

    R. Crew, S. Patel, A. Pai, I. Batal, H. Fernandez.

    Columbia University, New York

    Intro: CNIs improve kidney transplant (KT) survival, but have significant toxicities, including graft dysfunction (GD), neurotoxicity (NT), or thrombotic microangiopathy (TMA). Belatacept is an alternative…
  • 2017 American Transplant Congress

    Blockade of Tim-3 and PD-1 Reverses Dysfunctions of Tumor Infiltrating Lymphocytes in HBV Related Hepatocellular Carcinoma.

    A. Hu, F. Liu, X. Zhu, X. He.

    The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

    The immunosuppression of tumor infiltrating lymphocytes (TILs) is associated with rapid progress of hepatitis B virus related hepatocellular carcinoma (HBV-HCC). The inhibition molecules of T…
  • 2017 American Transplant Congress

    Allograft Cytokine Activation and Elevated Tissue Indoleamine 2,3-Dioxygenase Gene and Protein Expression in Rejecting Pig Transplants.

    T. Merchen,1 Y. Wang,2 R. Lassiter,1 D. Kleven,3 R. Jajosky,3 M. Winn,2 C.-S. Ho,5 N. Nahman.4

    1Surgery, MCG at Augusta University, Augusta, GA; 2Medicine, MCG at Augusta University, Augusta, GA; 3Pathology, MCG at Augusta University, Augusta, GA; 4Norwood VAMC, Augusta, GA; 5Gift of Life Michigan, Ann Arbor, MI

    Viral delivery of the indoleamine 2,3-dioxygenase (IDO) transgene results in transprotein synthesis and mitigates rejection in rodent kidney transplants (J Gene Med 13:373); but in…
  • 2017 American Transplant Congress

    Understanding the Role of Induction Agents in Older versus Younger Kidney Transplant Recipients.

    Q. Huang, F. Ammary, M. McAdams-DeMarco, D. Segev.

    Johns Hopkins University, Baltimore, MD

    Background: There has been an increase in the number of older (over 65) KT recipients. Aging-related changes such as differences in immune senescence may influence…
  • 2017 American Transplant Congress

    Photopheresis for Recalcitrant Rejection After Heart Transplantation: Worthwhile?

    J. Patel, M. Kittleson, X. Zhang, E. Klapper, T. Aintablian, K. Murayama, L. Czer, D. Geft, D. Chang, J. Kobashigawa.

    Cedars-Sinai Heart Institute, Los Angeles

    Background: Rejection is leading cause of mortality after heart transplantation (HTx). While the rates of rejection have declined over the past few decades from improvement…
  • 2017 American Transplant Congress

    Soluble Fibrinogen-Like Protein 2 Regulates Differentiation and Enhances Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Allograft Immunity.

    C. Yang, B. Peng, M. Xu, T. Zhu.

    Urology, Zhongshan Hospital, Fudan University, Shanghai, China

    Soluble fibrinogen-like protein 2 (sFGL2) is a novel immunoregulatory molecule, secreted mainly by regulatory T cells. CD11b+ Gr1+ myeloid-derived suppressor cells (MDSCs) are an important…
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