2017 American Transplant Congress
Trends in Infection Among Kidney Transplant Recipients, 1999-2013.
Johns Hopkins School of Medicine, Baltimore, MD
Modern immunosuppression regimens have substantially reduced acute rejection and improved patient and graft survival over the last decades. However, such potent regimens may also have…2017 American Transplant Congress
Variability in Tacrolimus Concentrations Across Pediatric Solid Organ Transplants.
PURPOSE: We characterized the evolution of out-of-range tacrolimus (TAC) concentrations and associated factors during 1 year following a pediatric solid organ transplant (SOT).METHODS: Heart, kidney…2017 American Transplant Congress
Early and Late High Intrapatient Variability of Tacrolimus Levels Can Predict Late Renal Allograft Rejection.
Introduction Nonadherence to immunosuppressive medication can start any time after transplantation and is associated with rejection and graft loss. We have previously shown that high…2017 American Transplant Congress
Conversion from Tacrolimus-Based to Everolimus-Based Immunosuppressive Therapy 3 Months After Living-Donor Kidney Transplantation: A Randomized-Controlled Clinical Trial.
While conversion from ciclosporin to everolimus is well documented, conversion from tacrolimus has been poorly studied. In this randomized-controlled trial the safety and tolerability of…2017 American Transplant Congress
A Novel, Dose-Adjusted Tacrolimus Trough Concentration (TTC) Model for Prediction and Variance Estimation.
Given that a high tacrolimus (tac) intrapatient variability (IPV) increases the risk for a poor kidney transplant (tx) outcome, some experts advocate routine IPV monitoring…2017 American Transplant Congress
Evolution of CCR4highCD4+ Subpopulations in Renal Graft Blood After Steroid Withdrawal: A Prospective, Randomized, Controlled Study in Parallel Groups. Preliminary Results.
Introduction:Steroids are a mainstay of immunosuppression after kidney transplant (KT). The infiltration into the graft of active T cells following KT depends on the expression…2017 American Transplant Congress
This is Why We Can't Have Nice Things- Real World Experience with Everolimus in Livers.
Purpose: To determine if discontinuation rates of everolimus (RAD) in clinical practice is higher than the 30% demonstrated in trials.Methods: This was a retrospective cohort…2017 American Transplant Congress
Baseline Immune Assessment to Individualize Immunosuppression in SPK Recipients with Type 1 Diabetes.
Introduction:Type 1 diabetes (T1D) is an immune-mediated disorder associated with multiple immunological anomalies. Immunologic abnormalities might help to explain why recipients of simultaneous pancreas kidney…2017 American Transplant Congress
Belatacept in Chronic Kidney Disease Stabilizes and Improves Renal Function in Pancreas Transplant Recipients: Intermediate Results.
Indiana University Health, Indianapolis
Background: We report our experience in converting Pancreas Transplant recipients from tacrolimus to Belatacept in order to avoid further worsening of kidney function.Results: Eight (7…2017 American Transplant Congress
Mycophenolate Dose Reductions Are Not Associated with De Novo Donor-Specific Antibodies.
University of Colorado, Aurora, CO
De novo donor-specific antibodies (dnDSA) are central to the development of antibody-mediated rejection, which is the most important cause of death-censored graft loss. It is…
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