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American Transplant Congress abstracts

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Articles tagged "Immunosuppression"

  • 2017 American Transplant Congress

    Conservative Management of Pneumatosis Intestinalis After Pediatric Liver Transplantation.

    R. Hendrickson, J. Ryan, L. Dandridge, W. Andrews, J. Daniel, R. Fischer, D. Rivard.

    Transplant Surgery, Developmental and Behavior Sciences, Hepatology and Radiology, Children's Mercy Hospital, Kansas City, MO

    BACKGROUND: Pnuematosis intestinalis (PI), characterized by gas in the bowel wall, is a rare pathologic finding in pediatric liver transplantation (PLT) recipients. PI has been…
  • 2017 American Transplant Congress

    A Novel MyD88 Inhibitor Attenuates Allograft Rejection in Heterotopic Tracheal Transplantation in Mice.

    M. Yang, X. Zhang, G. Chen, Z.-C. Ding, Y. Miao, Y. Yang, P. Zhou.

    Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technolog; Key Lab of Ministry of Education & Ministry of Health of China, Wuhan, Hubei, China

    Background: Obstructive bronchiolitis (OB) characterized by chronic rejection, is the main complication after lung transplantation which limits the long-term survival of the recipients. Innate immune…
  • 2017 American Transplant Congress

    Tacrolimus Dose Variability, CYP3A5 Genotype, and Acute Rejection in African American and European American Kidney Transplant Recipients.

    S. Seibert,1 D. Schladt,2 B. Wu,3 W. Guan,3 C. Dorr,2,7 D. Berglund,1 R. Remmel,4 A. Matas,5 R. Mannon,6 A. Israni,2,7 W. Oetting,1 P. Jacobson,1 For the DeKAF Genomics Investigators.

    1Dept of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota (UMN), Mpls, MN; 2Chronic Disease Research Group, Minneapolis Medical Research Foundation, Mpls, MN; 3Division of Biostatistics, School of Public Health, UMN, Mpls, MN; 4Dept of Medicinal Chemistry, College of Pharmacy, UMN, Mpls, MN; 5Division of Transplantation, Dept of Surgery, School of Medicine, UMN, Mpls, MN; 6Dept of Nephrology, University of Alabama, Birmingham, AL; 7Dept of Nephrology, Hennepin County Medical Center, School of Medicine, UMN, Mpls, MN

    Background: Poor immunosuppression with tacrolimus (TAC) after kidney transplantation contributes to the development of toxicity and loss of efficacy. We aimed to associate intra-patient TAC…
  • 2017 American Transplant Congress

    Determinants of Successful Use of Sirolimus in Renal Transplantation.

    M. Naik,1 W. Gwinner,2 W. Arns,3 E. Basic,10 K. Budde,1 F. Diekmann,4 M. Fischereder,5 J. Goßmann,6 K. Heller,7 N. Heyne,8 J.-S. Jürgensen,1 C. Morath,9 U. Riester.10

    1GSSG, Berlin, Germany; 2GSSG, Hannover, Germany; 3GSSG, Köln, Germany; 4GSSG, Barcelona, Spain; 5GSSG, München, Germany; 6GSSG, Frankfurt, Germany; 7GSSG, Erlangen, Germany; 8GSSG, Tübingen, Germany; 9GSSG, Heidelberg, Germany; 10GSSG - Pfizer, Berlin, Germany

    Sirolimus (SLR) is an established component in the immunosuppressive treatment after renal transplantation.The side effects of SLR differ from other immunosuppressants and may limit its…
  • 2017 American Transplant Congress

    CMV and BK Virus Infections in Kidney Transplant Recipients Receiving an mTORi-Based Regimen versus a CNI-Based Regimen: A Systematic Review and Meta-Analysis.

    B. Tanios,1 S. Mallat,1 H. Itani,1 T. Lotfi,1 S. Gabardi,2 E. Akl,1 J. Azzi.2

    1Division of Nephrology, American University of Beirut Medical Center, Beirut, Lebanon; 2Renal Division, Harvard Medical School, Boston

    The objective of this systematic review is to compare the incidence of CMV and BK virus infections in kidney transplant recipients receiving an mTORi-based as…
  • 2017 American Transplant Congress

    Everolimus Is Associated with Less Weight Gain Than Tacrolimus Two Years Following Liver Transplantation: Results of a Randomized Multicenter Study.

    M. Charlton,1 M. Rinella,2 D. Patel,3 K. McCague,3 J. Heimbach,4 K. Watt.4

    1Intermountain Medical Center, Salt Lake City; 2Northwestern University, Chicago; 3Novartis Pharmaceuticals Corp., East Hanover; 4Mayo Clinic, Rochester

    Weight gain after liver transplant may lead to post-transplant complications, and is a risk factor for post-transplant metabolic syndrome (PTMS), cardiovascular events, and renal insufficiency.…
  • 2017 American Transplant Congress

    Higher Tacrolimus Blood Levels Predict Better Graft Survival in Kidney Recipients with De Novo DSA.

    M.-A. Béland,1 R. Noël,1 I. Côté,1 I. Lapointe,1 E. Wagner,2 J. Riopel,3 E. Latulippe,3 O. Désy,1 S. Béland,1 I. Houde,1 S. De Serres.1

    1Renal Division, CHU de Quebec, Laval University, Quebec City, QC, Canada; 2Immunology and Histocompatibility, CHU de Quebec, Laval University, Quebec City, QC, Canada; 3Pathology, CHU de Quebec, Laval University, Quebec City, QC, Canada

    Background: De novo anti-HLA donor specific antibodies (dnDSA) are associated with poorer outcomes in kidney transplant recipients. Nonetheless, their monitoring post transplant is not widespread,…
  • 2017 American Transplant Congress

    Anti-CD40 mAb Promotes Kidney Immunoregulatory Capacity in NHP Transplants by Altering Kidney Tubular Cell (TEC) Expression of CD40 and IL-6.

    J. Arp,1 Y. Ma,1 H. Yang,2 A. El Warrak,1 A. Haig,1 W. Liu,1 K. Reimann,3 P. Luke,1 Z. Zhang,1 D. Rothstein,4 A. Jevnikar.1

    1Medicine, Pathology & Microbiology & Immunology, Western University, London, ON, Canada; 2Sichuan Provincial Hospital, Chengdu, Sichuan, China; 3University of Massachusetts, Boston, MA; 4University of Pittsburgh, Pittsburgh, PA

    Treatment of cynolmolgus monkey (NHP) renal transplant recipients with a combination of 2 rhesus-mouse chimeric α-CD45RB (r6G3R1; 6G3) and α-CD40 (r2C10R4; 2C10) mAbs increased circulating…
  • 2017 American Transplant Congress

    Steroid Withdrawal and De Novo Donor-Specific HLA Antibodies in Renal Transplant Patients: A Prospective, Randomized, Controlled Study in Parallel Groups. Preliminary Results.

    J. Alonso-Titos,1 P. Ruiz-Esteban,1 E. Palma,1 V. Lopez,1 A. Caballero,2 M. Leon,3 M. Cobos,4 J. Cruzado,5 J. Sellares,6 A. Torres,4 D. Hernandez.1

    1Nephrology, Regional University Hospital and Malaga University, IBIMA, RD16/0009/0006, Malaga, Spain; 2Immunology, Regional University Hospital, Malaga, Spain; 3Pathology, Regional University Hospital, Malaga, Spain; 4Nephrology, Hospital Universitario de Canarias, CIBICAN, University of La Laguna, RD16/0009/0031, Tenerife, Spain; 5Nephrology, IDIBELL, Hospital de Bellvitge, RD16/0009/0003, Barcelona, Spain; 6Nephrology, Hospital Universitari Vall d'Hebron, RD 16/0009/0030, Barcelona, Spain

    Introduction: Steroids represent a mainstay of immunosuppression after kidney transplant (KT). Steroid withdrawal reduces metabolic and cardiovascular complications, but whether it increases the risk of…
  • 2017 American Transplant Congress

    Alemtuzumab Induction Is Associated with a Lower Incidence of BK Virus Nephropathy Compared with IL2RA Induction.

    A. Gueret-Wardle, S. Hassan, G. Lucisano, C. Roufosse, M. Willicombe, D. Taube.

    Renal Medicine, West London Renal and Transplant Centre, London, United Kingdom

    Introduction:BK polyoma virus associated nephropathy [BKVAN] is a major cause of allograft dysfunction and graft loss occurring in up to 10% of kidney allograft recipients…
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