ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunosuppression"

  • 2017 American Transplant Congress

    Immunosuppressive Role of Pancreas Derived Mesenchymal Stem Cells.

    M. Kanak,1 F. Kunnathodi,2 M. Levy,1,3 M. Lawrence,2 B. Naziruddin.4

    1Transplant Surgery, Virginia Commonwealth University, Richmond, VA; 2Baylor Research Institute, Dallas, TX; 3Hume-Lee Transplant Center, VCU Health System, Richmond, VA; 4Simmons Transplant Institute, Baylor Scott and White Health, Dallas, TX

    BackgroundThe Edmonton protocol revived islet transplantation therapy for Type-1 Diabetic patients. However, Long-term islet function still remains a challenge. Immunosuppression used after islet transplantation contributes…
  • 2017 American Transplant Congress

    Comparison of Long Term Renal Function Outcomes for Everolimus (EVR) vs. Sirolimus (SIR) vs. Mycophenolate Acid (MPA) Immunosuppressive Regimens Post Kidney Transplant (Ktx).

    H. Tedesco,1 W. Irish,2 K. Dharmesh,3 D. Patel,3 D. Cibrik.4

    1Hospital do Rim UNIFESP, Sao Paulo, Brazil; 2CTI Consulting, Raleigh; 3Novartis Pharmaceuticals Corporation, East Hanover; 4University of Michigan, Ann Arbor

    MPA or mammalian target of rapamycin inhibitors (mTORi [EVR or SIR]) in combination with calcineurin inhibitors (CNI, tacrolimus [TAC] or cyclosporine) are used for maintenance…
  • 2017 American Transplant Congress

    Early Exposure of Everolimus with and without Calcineurin Inhibitors.

    C. Felipe, A. Ferreira, T. Abait, A. Bessa, P. Ruppel, L. Hiramoto, M. Ivani, H. Tedesco, J. Medina- Pestana.

    Nephrology Division, Hospital do Rim, UNIFESP, São Paulo, SP, Brazil

    This study aimed to evaluate the effect of cyclosporine (CSA) or tacrolimus (TAC) on early exposure of everolimus (EVR).A cohort of 306 kidney transplant recipients…
  • 2017 American Transplant Congress

    Subclinical Histologic Findings Are Observed in 25% of Stable Adult Liver Transplant Recipients (ALTRs) Screened for Immunosuppression Withdrawal (ISW): OPTIMAL (NCT02533180).

    S. Chandran,1 M. Abecassis,2 J. Levitsky,2 S. Feng,3 A. Humar,4 J. Emond,5 G. Klintmalm,6 A. Demetris,4 K. Much,7 L. Sun,1 A. Priore,8 D. Ikle,7 N. Bridges,8 M. DesMarais,1 B. Burrell,9 J. Markmann.10

    1ITN, San Francisco; 2Northwestern, Chicago; 3UCSF, San Francisco; 4UPMC, Pittsburgh; 5Columbia, New York; 6Baylor, Dallas; 7Rho, Chapel Hill; 8NIAID/NIH, Bethesda; 9ITN, Bethesda; 10MGH, Boston

    OPTIMAL is a 6-center ISW study in non-autoimmune, non-HCV ALTRs ≥3 yrs post-transplant (tx). Studies have shown a correlation between portal inflammation associated with tissue…
  • 2017 American Transplant Congress

    Protease Inhibitor-Based Regimens Are Associated with Inferior Outcomes in HIV-Infected Kidney Transplant Recipients.

    B. Shelton,1 D. Sawinski,2 R. Reed,1 P. MacLennan,1 S. Mehta,1 J. Locke.1

    1University of Alabama at Birmingham, Birmingham; 2University of Pennsylvania, Philadelphia

    Background: Excellent outcomes have been demonstrated among HIV-infected kidney transplant (KT) recipients when HIV infection is well-controlled. Protease inhibitors (PI) have significant drug-drug interactions with…
  • 2017 American Transplant Congress

    The Phenotypic and Functional Characteristics of a Novel CD11b+CD11c+F4/80+ Monocytic Myeloid-Derived Suppressor Cell Subset.

    B. Jiang,1,2 I. Aljabban,1 C. Yang,1 D. Ndishabandi,1 R. White,1 P. Russell,1 J. Madsen,1 R. Colvin,1 A. Alessandrini.1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston; 2Dept. of Cardiac Surgery, Second Xiangya Hospital, Central South University, Changsha, China

    Background: CD11b+Ly6G-Ly6Chigh monocytic myeloid-derived suppressor cells (M-MDSCs) in mice can promote the apoptosis of T cells and induce regulatory T cells. Novel CD11b+CD11c+F4/80+ cells were…
  • 2017 American Transplant Congress

    Efficacy and Safety of Everolimus with Reduced-Exposure Tacrolimus and Corticosteroid Withdrawal in De Novo Pediatric Renal Transplant Recipients: 12-Month Results from the CRADLE Study.

    R. Ettenger,1 B. Tönshoff,1 H. Tedesco,1 L. Dello Strologo,1 S. Marks,1 L. Pape,1 E. Martzloff,2 B. Rauer,2 J. Ng,3 P. Lopez.2

    1A2314 Study Group, Los Angeles; 2Novartis Pharma AG, Basel, Switzerland; 3Novartis Pharmaceutical Corporation, East Hanover

    PURPOSE: We present 12-month (M) results from the CRADLE study (NCT01544491) that assessed efficacy and safety of everolimus (EVR) with reduced-exposure tacrolimus (rTAC) and early…
  • 2017 American Transplant Congress

    The Feared Five Fungal Infections in Kidney Transplant Recipients: 20-Year Experience at a Midwestern Center.

    S. Parajuli, A. Wick, S. Pandeya, B. Astor, J. Smith, A. Djamali, D. Mandelbrot.

    University of Wisconsin, Madison, WI

    Invasive fungal infections (IFI) are increasing in kidney transplant recipients (KTR). Here we present our experience with five feared IFIs in KTR transplanted between 01/01/1994…
  • 2017 American Transplant Congress

    Second-Line Therapy After Standard of Care in Antibody-Mediated Rejection: A Prospective Study.

    D. Viglietti, A. Loupy, O. Aubert, E. Pillebout, C. Legendre, D. Glotz, C. Lefaucheur.

    Paris Translational Research Center for Organ Transplantation, Paris, France

    There is a marked heterogeneity in AMR patients' prognosis after SOC treatment including plasma exchange (PE) and intravenous immunoglobulins (IVIG). We investigated whether a composite…
  • 2017 American Transplant Congress

    Felodipine Diminishes Decline in Glomerular Filtration Rate in Lung Transplanted Patients Treated with Cyclosporine: A Randomized Placebo Controlled Trial.

    M. Hornum,1 M. Iversen,2 P. Oturai,3 M. Andersen,2 M. Zemtsovski,4 P. Bredahl,4 N. Bjarnason,2 K. Christiansen,5 J. Carlsen,2 C. Møller,6 B. Feldt-Rasmussen,1 M. Perch.2

    1Nephrology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; 2Cardiology, Section for Lung Transplantation, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; 3Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; 4Cardiothoracic Anaesthesiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; 5Public Health, Section of Biostatics, University of Copenhagen, Copenhagen, Denmark; 6Cardiothoracic Surgery, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark

    Background. Calcium channel blockers may ameliorate the decline in renal function caused by calcineurin inhibitors in lung transplant (LTX) recipients. We previously demonstrated a 47…
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