2017 American Transplant Congress
Pre-Transplant Panel Reactive T Cells (PRT) with IL-15 as a Risk-Stratifier of Acute Rejection in Kidney Transplant Patients on Belatacept Therapy.
While kidney transplant recipients treated with bela without calcineurin inhibitors (CNI) have better 5-10y eGFR versus those on CNI, Belatacept (bela) use is associated with…2017 American Transplant Congress
Rapamycin Maintenance Therapy in Pediatric Liver Transplant Recipients Associated with Trend Toward Decreasing Th2 Cytokine Levels Compared to Tacrolimus Therapy.
1Children's Mercy Hospital, Kansas City, MO; 2University of Kansas Medical Center, Kansas City, KS
Background: Maintenance immunosuppression after liver transplantation with tacrolimus (TAC) may have progressive fibrosis on serial allograft biopsies. mTOR inhibitors such as rapamycin (RAPA) may abrogate…2017 American Transplant Congress
Lower Mean Tacrolimus Troughs Increase Risk of De Novo Donor-Specific Antibodies in the First Year of Kidney Transplant.
University of Colorado, Aurora, CO
Development of de novo donor-specific antibodies (dnDSA) is the first step in the evolution of antibody-mediated rejection, which constitutes the leading cause of death-censored graft…2017 American Transplant Congress
The Gut Microbiota Regulates Murine Cardiac Transplant Outcome.
Background: Gut microbiota regulates systemic immunity and can activate pro- or anti-inflammatory pathways. We hypothesized that the gut microbiota influences the survival of mismatched murine…2017 American Transplant Congress
CTLA4Ig Suppresses Memory Responses to HLA-A2+ Skin Grafts in a Mouse Model of Allosensitization by Reducing CD138+ Plasma Cells.
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
Purpose: In previous studies we demonstrated that CTLA4Ig suppresses de novo T-cell activation through blocking CD28 co-stimulation and attenuates recall alloantibody responses following re-exposure to…2017 American Transplant Congress
Inflammatory Conditions Dictate the Effect of MSC on B Cell Function.
The immunomodulatory capacity of mesenchymal stem or stromal cells (MSC) makes them a promising therapeutic tool for immune disease and organ transplantation. The effects of…2017 American Transplant Congress
Evaluation of Immunological States of Patients with Cytomegalovirus Infection After Kidney Transplantation.
Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
Background: Generally, it is thought that strong immunosuppression causes cytomegalovirus (CMV) infection after kidney transplantation (KT); thus, physicians often reduce the dose of the immunosuppressant…2017 American Transplant Congress
Long-Term Immunosuppression Adherence After Kidney Transplant and Relationship to Allograft Histology.
Background: Loss of Medicare coverage for immunosuppression 3 years after kidney transplant may be associated with increased nonadherence. The goal of this study was to…2017 American Transplant Congress
Impact of Pretransplant Panel-Reactive Antibody Level on Ocular Surface Stem Cell Survival and Visual Outcome.
1University of Cincinnati, Cincinnati, OH; 2Cincinnati Eye Institute, Cincinnati, OH
Purpose: Panel-Reactive Antibody (PRA) is a screening test for a range of known human leukocyte antigens which signifies the proportion of the population that the…2017 American Transplant Congress
Impact of Intensive Dosing of Mycophenolate on Pancreas Allograft Survival.
1Pharmacy, UW Health, Madison, WI; 2Transplant Surgery, UW Health, Madison, WI
Purpose: The primary objective was to evaluate the effect of mycophenolate (MPA) dicharge (DC) dose on pancreas allograft (PTX) survival. Secondary endpoints included patient survival…
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